About Enhancer
| Enhancer ID: | E_02_0801 |
| Species: | human |
| Position : | chr11:17666830-17677080   |
| Biosample name: | |
| Experiment class : | Low+High throughput |
| Enhancer type: | Super-Enhancer |
| Disease: | Alveolar rhabdomyosarcoma |
| Pubmed ID: | 28446439 |
| Enhancer experiment: | ChIP-seq,4C,Luciferase Reporter Assay |
| Enhancer experiment description: | We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET |
About Target gene
| Target gene : | MYOD1(MYF3,MYOD,PUM,bHLHc1),MYOD1(MYF3,MYOD,PUM,bHLHc1) |
| Strong evidence: | 4C |
| Less strong evidence: | ChIP-seq,Luciferase Reporter Assay |
| Target gene experiment description: | We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET;We found PAX3-FOXO1 most frequently occupied the strong Enhancer chromatin state , exemplified by known PAX3-FOXO1 target FGFR4 and oncogenes MYC, ALK and MET |
About TF
| TF name : | PAX3(CDHS,HUP2,WS1,WS3)FOXO1(FKH1,FKHRA,FOXO1)PAX3(CDHS,HUP2,WS1,WS3)FOXO1(FKH1,FKHRA,FOXO1) |
| TF experiment: | ChIP-qPCR,ChIP-seq |
| TF experiment description: | To gain insight into the epigenetic consequences of PAX3-FOXO1, we mapped the landscape of active and repressive histone marks by sequencing DNA enriched by chromatin immunoprecipitation (ChIP-seq) from a patient derived fusion positive FP-RMS cell line RH4. ;To gain insight into the epigenetic consequences of PAX3-FOXO1, we mapped the landscape of active and repressive histone marks by sequencing DNA enriched by chromatin immunoprecipitation (ChIP-seq) from a patient derived fusion positive FP-RMS cell line RH4. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene