About Enhancer
| Enhancer ID: |
E_02_0662 |
| Species: |
human |
| Position :
|
chrX:67541427-67543427
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Muscle invasive disease (muscle invasive disease) |
| Pubmed ID: |
31234917
|
| Enhancer experiment: |
PCR, Western blot, gel electrophoresis |
| Enhancer experiment description: |
ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals. |
About Target gene
| Target gene : |
AR,BCL2(Bcl-2,PPP1R50),BAX |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells. |
About TF
| TF name : |
-- |
| TF experiment: |
PCR,Western blot,???? |
| TF experiment description: |
ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells.;The combined therapy increases the expression of the pro-apoptosis BAX gene and cell cycle inhibitor p21 gene, yet suppresses the expression of the pro-survival BCL2 gene in miBCa cells. |
About Function
| Enhancer function : |
ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
ASC-J9? increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals. |
About SNP
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs