About Enhancer
| Enhancer ID: | E_01_0927 |
| Species: | human |
| Position : | chr6:137863759-137865759   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Immune disease |
| Pubmed ID: | 32239644 |
| Enhancer experiment: | PCR? qPCR |
| Enhancer experiment description: | By studying the lead expression?modulating SNP, we uncovered an NF??B?driven regulatory circuit which constrains T?cell activation through the dynamic formation of a super?enhancer that upregulates TNFAIP3 (A20), a key NF??B inhibitor. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | By studying the lead expression?modulating SNP, we uncovered an NF??B?driven regulatory circuit which constrains T?cell activation through the dynamic formation of a super?enhancer that upregulates TNFAIP3 (A20), a key NF??B inhibitor. |
About TF
| TF name : | TNFAIP3 |
| TF experiment: | PCR? qPCR |
| TF experiment description: | By studying the lead expression?modulating SNP, we uncovered an NF??B?driven regulatory circuit which constrains T?cell activation through the dynamic formation of a super?enhancer that upregulates TNFAIP3 (A20), a key NF??B inhibitor. |
About Function
| Enhancer function : | By studying the lead expression?modulating SNP, we uncovered an NF??B?driven regulatory circuit which constrains T?cell activation through the dynamic formation of a super?enhancer that upregulates TNFAIP3 (A20), a key NF??B inhibitor. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
By studying the lead expression?modulating SNP, we uncovered an NF??B?driven regulatory circuit which constrains T?cell activation through the dynamic formation of a super?enhancer that upregulates TNFAIP3 (A20), a key NF??B inhibitor. |
About SNP
| SNP ID: | rs6759298,rs4672505,rs13001372,rs1736137 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TNFAIP3 | Canonical NF-kappaB pathway | pid | 24 |
| TNFAIP3 | CD40/CD40L signaling | pid | 36 |
| TNFAIP3 | Negative regulators of RIG-I/MDA5 signaling | reactome | 34 |
| TNFAIP3 | NOD1/2 Signaling Pathway | reactome | 31 |
| TNFAIP3 | Regulation of TNFR1 signaling | reactome | 31 |
| TNFAIP3 | TNF receptor signaling pathway | pid | 46 |
| TNFAIP3 | TNFalpha | netpath | 274 |
| TNFAIP3 | TNFR1-induced NFkappaB signaling pathway | reactome | 26 |
| TNFAIP3 | TNFR1-induced proapoptotic signaling | reactome | 13 |
| TNFAIP3 | Toll receptor signaling pathway | panther | 44 |
| TNFAIP3 | NOD-like receptor signaling pathway | kegg | 60 |
| TNFAIP3 | Hs_TNF_alpha_Signaling_Pathway_WP231_89895 | wikipathways | 61 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene