About Enhancer
| Enhancer ID: | E_01_0342 |
| Species: | human |
| Position : | chr19:10130616-10132616   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Lung cancer |
| Pubmed ID: | 30596070 |
| Enhancer experiment: | Flow cytometry, cell transfection techniques, immunohistochemical staining, PCR, Western blot, chip seq |
| Enhancer experiment description: | Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 and DNMT3b expression in drug-resistant small cell lung cancer (SCLC). |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 and DNMT3b expression in drug-resistant small cell lung cancer (SCLC). |
About TF
| TF name : | DNMT1(ADCADN,AIM,CXXC9,DNMT,HSN1E,MCMT,m.HsaI) |
| TF experiment: | ??????????????????????PCR?Western blot?ChIP-seq |
| TF experiment description: | Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 and DNMT3b expression in drug-resistant small cell lung cancer (SCLC). |
About Function
| Enhancer function : | Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 and DNMT3b expression in drug-resistant small cell lung cancer (SCLC). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 and DNMT3b expression in drug-resistant small cell lung cancer (SCLC). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| DNMT1 | Cystathionine Beta-Synthase Deficiency | smpdb | 16 |
| DNMT1 | DNA methylation | reactome | 63 |
| DNMT1 | Glycine N-methyltransferase Deficiency | smpdb | 16 |
| DNMT1 | Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type | smpdb | 16 |
| DNMT1 | Hypermethioninemia | smpdb | 16 |
| DNMT1 | Methionine Adenosyltransferase Deficiency | smpdb | 16 |
| DNMT1 | Methionine Metabolism | smpdb | 16 |
| DNMT1 | NoRC negatively regulates rRNA expression | reactome | 104 |
| DNMT1 | PRC2 methylates histones and DNA | reactome | 71 |
| DNMT1 | Regulation of retinoblastoma protein | pid | 67 |
| DNMT1 | S-Adenosylhomocysteine (SAH) Hydrolase Deficiency | smpdb | 16 |
| DNMT1 | Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) | smpdb | 16 |
| DNMT1 | Cysteine and methionine metabolism | kegg | 36 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene