Cancer CRCdb

TF information

TF name:	THRB
TF family:	THR-like
Ensembl gene ID:	ENSG00000151090
Ensembl protein ID:	ENSP00000493709, ENSP00000414100, ENSP00000379904, ENSP00000496686, ENSP00000496095, ENSP00000348827, ENSP00000496509, ENSP00000494618, ENSP00000280696, ENSP00000496029, ENSP00000404898, ENSP00000496616, ENSP00000414444
Entrez gene ID:	7068

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of THRB in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_285	Cell line	Liver	HuH7_untreat	0.3205574912892

THRB distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_285	Liver	Cell line	HuH7_untreat

THRB distribution in all CRCs

Genomic distribution of SEs associated with THRB

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Mutation of THRB

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of THRB

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr3	24164413	24164413	G	T	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24164402	24164402	-	G	exonic	THRB	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443,LIHC\|1\|373\|0.00268,LUAD\|2\|543\|0.00368
-	chr3	24188296	24188296	G	A	exonic	THRB	synonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr3	24169139	24169139	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24185133	24185133	T	C	exonic	THRB	synonymous	UCEC\|1\|248\|0.00403
-	chr3	24231674	24231674	G	A	exonic	THRB	synonymous	SKCM\|1\|368\|0.00272
-	chr3	24164584	24164584	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24231596	24231596	C	A	exonic	THRB	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	24231770	24231770	G	A	exonic	THRB	synonymous	UCEC\|1\|248\|0.00403
-	chr3	24185066	24185066	T	C	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24185163	24185163	C	T	exonic	THRB	synonymous	SKCM\|2\|368\|0.00543
-	chr3	24188166	24188166	A	T	exonic	THRB	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	24231751	24231751	A	G	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24231827	24231827	T	C	splicing	THRB	splicing	LUAD\|1\|543\|0.00184
rs138865141	chr3	24231704	24231704	C	T	exonic	THRB	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,UCEC\|1\|248\|0.00403
rs760749837	chr3	24270443	24270443	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24231761	24231761	T	G	exonic	THRB	synonymous	SKCM\|1\|368\|0.00272
-	chr3	24231725	24231725	G	A	exonic	THRB	synonymous	UCEC\|1\|248\|0.00403
-	chr3	24231690	24231690	T	C	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24231681	24231681	G	A	exonic	THRB	nonsynonymous	DLBC\|1\|48\|0.02083,SKCM\|1\|368\|0.00272
rs760778175	chr3	24231773	24231773	G	A	exonic	THRB	synonymous	PAAD\|1\|185\|0.00541
-	chr3	24169144	24169144	C	T	exonic	THRB	synonymous	BLCA\|1\|396\|0.00253
-	chr3	24188267	24188267	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
rs144206187	chr3	24164462	24164462	G	A	exonic	THRB	synonymous	SKCM\|2\|368\|0.00543
-	chr3	24185142	24185142	C	T	exonic	THRB	synonymous	SKCM\|1\|368\|0.00272
-	chr3	24169111	24169111	C	T	exonic	THRB	synonymous	SKCM\|3\|368\|0.00815
-	chr3	24169179	24169179	C	T	exonic	THRB	nonsynonymous	UCEC\|1\|248\|0.00403
rs121918690	chr3	24169185	24169185	C	T	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24185123	24185123	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24164390	24164390	T	G	exonic	THRB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	24188211	24188211	C	A	exonic	THRB	stopgain	SKCM\|1\|368\|0.00272
rs773691913	chr3	24164570	24164570	A	G	exonic	THRB	synonymous	SARC\|1\|247\|0.00405
-	chr3	24169075	24169075	G	T	exonic	THRB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	24164407	24164407	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24185029	24185029	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24174881	24174881	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24231691	24231691	G	T	exonic	THRB	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	24164380	24164380	C	A	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24169196	24169196	A	C	exonic	THRB	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	24164475	24164475	C	A	exonic	THRB	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	24193966	24193966	T	C	exonic	THRB	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs371602445	chr3	24185091	24185091	C	T	exonic	THRB	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24185134	24185134	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24193953	24193953	G	A	exonic	THRB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs752884233	chr3	24185105	24185105	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
rs142830943	chr3	24185190	24185190	C	T	exonic	THRB	synonymous	SKCM\|1\|368\|0.00272
-	chr3	24185170	24185170	G	A	exonic	THRB	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	24231684	24231684	G	A	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24231793	24231793	G	T	exonic	THRB	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	24231811	24231811	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24185077	24185077	T	C	exonic	THRB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	24164384	24164384	G	A	exonic	THRB	synonymous	UCEC\|2\|248\|0.00806
-	chr3	24193892	24193892	C	T	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272
-	chr3	24164618	24164618	T	C	splicing	THRB	splicing	LUAD\|1\|543\|0.00184
rs115360190	chr3	24185037	24185037	C	T	exonic	THRB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	24231679	24231679	G	A	exonic	THRB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	24188298	24188298	T	C	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24231691	24231691	G	A	exonic	THRB	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24231781	24231781	G	T	exonic	THRB	synonymous	LUAD\|1\|543\|0.00184
-	chr3	24231676	24231676	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24164438	24164438	G	A	exonic	THRB	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	24188201	24188201	A	T	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs121918697	chr3	24169122	24169122	G	A	exonic	THRB	nonsynonymous	LAML\|1\|197\|0.00508
-	chr3	24188169	24188169	C	T	exonic	THRB	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	24169079	24169079	G	A	exonic	THRB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	24185072	24185072	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24174936	24174936	T	G	exonic	THRB	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	24185008	24185008	T	C	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs867926730	chr3	24188225	24188225	C	T	exonic	THRB	nonsynonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	24188277	24188277	G	A	exonic	THRB	nonsynonymous	SKCM\|2\|368\|0.00543
rs143993214	chr3	24185082	24185082	G	A	exonic	THRB	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	24185009	24185009	G	T	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs368681026	chr3	24185081	24185081	C	T	exonic	THRB	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	24164556	24164556	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24193920	24193920	G	T	exonic	THRB	synonymous	HNSC\|1\|512\|0.00195
-	chr3	24231668	24231668	C	T	exonic	THRB	synonymous	BLCA\|1\|396\|0.00253
-	chr3	24169121	24169121	C	T	exonic	THRB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	24174828	24174828	T	C	exonic	THRB	synonymous	LUAD\|1\|543\|0.00184
rs768167319	chr3	24185038	24185038	G	A	exonic	THRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	24174907	24174907	C	G	exonic	THRB	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	24185073	24185073	C	T	exonic	THRB	stopgain	SKCM\|1\|368\|0.00272
-	chr3	24185144	24185144	G	A	exonic	THRB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	24231565	24231565	C	T	exonic	THRB	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr3	24181759	24181764	TCGAGT	-	intronic	THRB	unknown	-
rs776036533	chr3	24231772	24231772	C	T	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
rs756399184	chr3	24231643	24231643	G	A	exonic	THRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	24164567	24164567	A	G	exonic	THRB	synonymous	SARC\|1\|247\|0.00405
rs555044657	chr3	24174822	24174822	C	T	exonic	THRB	synonymous	LUAD\|1\|543\|0.00184
-	chr3	24169035	24169035	C	T	exonic	THRB	nonsynonymous	BRCA\|1\|982\|0.00102
rs115445992	chr3	24169081	24169081	G	A	exonic	THRB	synonymous	SARC\|1\|247\|0.00405

Disease information of THRB

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
THRB	Diaphragmatic Hernia	C23	Anatomical Abnormality	CTD_human
THRB	Osteogenesis Imperfecta	C05;C16;C17	Congenital Abnormality; Disease or Syndrome	GENOMICS_ENGLAND
THRB	Follicular thyroid carcinoma	C04	Neoplastic Process	CTD_human
THRB	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
THRB	THYROID HORMONE RESISTANCE, SELECTIVE PITUITARY	C19	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
THRB	THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT	C19	Disease or Syndrome	CTD_human;UNIPROT
THRB	Thyroid Hormone Resistance Syndrome	C19	Disease or Syndrome	CTD_human;GENOMICS_ENGLAND;ORPHANET
THRB	Thyroid Hormone Resistance, Generalized, Autosomal Recessive	C19	Disease or Syndrome	CTD_human;ORPHANET
THRB	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with THRB

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001947	RXR and RAR heterodimerization with other nuclear receptor	pid	26	164
pathway0002570	Neuroactive ligand-receptor interaction	kegg	272	560

Go term information of THRB

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GO_term_name	GO_term_type	TF_name
GO_LUNG_EPITHELIUM_DEVELOPMENT	BP	THRB
GO_LUNG_CELL_DIFFERENTIATION	BP	THRB
GO_MATING	BP	THRB
GO_REPRODUCTIVE_BEHAVIOR	BP	THRB
GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY	BP	THRB
GO_MATING_BEHAVIOR	BP	THRB
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	THRB
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY	MF	THRB
GO_CHROMATIN_DNA_BINDING	MF	THRB
GO_HORMONE_BINDING	MF	THRB

Survival analysis of THRB

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of THRB

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)