Cancer CRCdb

TF information

TF name:	TCF3
TF family:	bHLH
Ensembl gene ID:	ENSG00000071564
Ensembl protein ID:	ENSP00000467508, ENSP00000396363, ENSP00000344375, ENSP00000468487, ENSP00000465510, ENSP00000262965, ENSP00000378813, ENSP00000466565, ENSP00000466952, ENSP00000468481, ENSP00000465549, ENSP00000480564
Entrez gene ID:	6929

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TCF3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.23529411764706

TCF3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

TCF3 distribution in all CRCs

Genomic distribution of SEs associated with TCF3

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Mutation of TCF3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TCF3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr19	1615392	1615392	G	T	exonic	TCF3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	1615672	1615672	G	A	intronic	TCF3	unknown	SKCM\|1\|368\|0.00272
rs377185315	chr19	1612274	1612274	G	A	exonic	TCF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs763513002	chr19	1615610	1615610	C	T	intronic	TCF3	unknown	SKCM\|1\|368\|0.00272
-	chr19	1615322	1615322	G	A	exonic	TCF3	nonsynonymous	PRAD\|1\|499\|0.00200
rs1052768	chr19	1615428	1615428	G	A	exonic	TCF3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	1611797	1611797	T	-	exonic	TCF3	frameshift	PRAD\|1\|499\|0.00200
-	chr19	1623968	1623968	C	A	exonic	TCF3	synonymous	LUAD\|1\|543\|0.00184
-	chr19	1620979	1620979	G	-	exonic	TCF3	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
rs767680626	chr19	1615437	1615437	G	A	exonic	TCF3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs756484433	chr19	1621849	1621849	C	T	exonic	TCF3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	1650219	1650219	A	G	exonic	TCF3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr19	1621937	1621937	A	G	exonic	TCF3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	1611752	1611752	G	A	exonic	TCF3	nonsynonymous	SKCM\|1\|368\|0.00272
rs761036422	chr19	1619184	1619184	A	G	exonic	TCF3	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr19	1615480	1615480	C	G	exonic	TCF3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr19	1632117	1632117	T	C	splicing	TCF3	splicing	LUAD\|1\|543\|0.00184
rs780136754	chr19	1615576	1615576	C	T	intronic	TCF3	unknown	PAAD\|1\|185\|0.00541
rs749950119	chr19	1615385	1615385	C	T	exonic	TCF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs764523561	chr19	1615383	1615383	T	C	exonic	TCF3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr19	1615702	1615702	G	T	exonic	TCF3	synonymous	SKCM\|1\|368\|0.00272
-	chr19	1615541	1615541	G	A	intronic	TCF3	unknown	SKCM\|1\|368\|0.00272
-	chr19	1615558	1615558	G	A	intronic	TCF3	unknown	HNSC\|1\|512\|0.00195
rs147133056	chr19	1650226	1650226	C	A	exonic	TCF3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs143212973	chr19	1615393	1615393	C	T	exonic	TCF3	synonymous	DLBC\|1\|48\|0.02083
-	chr19	1615465	1615465	C	G	exonic	TCF3	nonsynonymous	BLCA\|1\|396\|0.00253
rs199628190	chr19	1627405	1627405	C	T	exonic	TCF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
rs746665695	chr19	1615287	1615287	G	A	exonic	TCF3	stopgain	UCEC\|1\|248\|0.00403
rs759178145	chr19	1612362	1612362	C	T	exonic	TCF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	1611812	1611812	C	A	exonic	TCF3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr19	1625583	1625583	C	T	exonic	TCF3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr19	1612391	1612391	C	A	exonic	TCF3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs1052738	chr19	1615477	1615477	C	T	exonic	TCF3	synonymous	PRAD\|2\|499\|0.00401
rs199702817	chr19	1623968	1623968	C	T	exonic	TCF3	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr19	1650215	1650215	G	A	exonic	TCF3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	1615573	1615573	G	A	intronic	TCF3	unknown	SKCM\|1\|368\|0.00272
rs1140828	chr19	1619333	1619333	G	A	exonic	TCF3	synonymous	ACC\|10\|90\|0.11111
rs747096662	chr19	1611810	1611810	G	A	exonic	TCF3	stopgain	UCEC\|1\|248\|0.00403
rs755661624	chr19	1625651	1625651	C	T	exonic	TCF3	synonymous	UCEC\|1\|248\|0.00403
-	chr19	1619469	1619469	C	G	exonic	TCF3	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs369170586	chr19	1615638	1615638	C	T	intronic	TCF3	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756584024	chr19	1623966	1623966	G	A	exonic	TCF3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr19	1612215	1612215	-	A	exonic	TCF3	frameshift	BRCA\|1\|982\|0.00102
rs1052696	chr19	1619348	1619348	G	A	exonic	TCF3	synonymous	ACC\|4\|90\|0.04444
-	chr19	1625595	1625595	C	A	exonic	TCF3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	1619335	1619335	C	G	exonic	TCF3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr19	1612209	1612209	G	A	exonic	TCF3	stopgain	PRAD\|1\|499\|0.00200
-	chr19	1625599	1625599	G	A	exonic	TCF3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr19	1625578	1625578	G	A	exonic	TCF3	synonymous	SKCM\|1\|368\|0.00272
-	chr19	1650209	1650209	G	A	exonic	TCF3	synonymous	DLBC\|1\|48\|0.02083
rs377363979	chr19	1621856	1621856	G	A	exonic	TCF3	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125,UCEC\|1\|248\|0.00403
-	chr19	1615708	1615708	C	G	exonic	TCF3	synonymous	BRCA\|1\|982\|0.00102
-	chr19	1615671	1615671	G	A	intronic	TCF3	unknown	SKCM\|1\|368\|0.00272
-	chr19	1615665	1615665	-	CGA	intronic	TCF3	unknown	HNSC\|1\|512\|0.00195
rs553896459	chr19	1619317	1619317	G	A	exonic	TCF3	synonymous	HNSC\|1\|512\|0.00195
rs544599787	chr19	1615592	1615592	G	A	intronic	TCF3	unknown	UCEC\|1\|248\|0.00403
-	chr19	1619133	1619133	G	C	exonic	TCF3	nonsynonymous	LUAD\|1\|543\|0.00184
rs763884772	chr19	1612376	1612376	C	T	exonic	TCF3	nonsynonymous	THCA\|1\|504\|0.00198
rs748050498	chr19	1623996	1623996	G	A	exonic	TCF3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs867551757	chr19	1632397	1632397	C	A	exonic	TCF3	nonsynonymous	ESCA\|1\|185\|0.00541
rs535762587	chr19	1627410	1627410	C	T	exonic	TCF3	nonsynonymous	THCA\|1\|504\|0.00198
rs753925052	chr19	1612308	1612308	G	A	exonic	TCF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	1625673	1625673	C	T	exonic	TCF3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr19	1615323	1615323	C	T	exonic	TCF3	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr19	1612404	1612404	C	T	exonic	TCF3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr19	1625590	1625590	C	T	exonic	TCF3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr19	1615701	1615701	G	A	exonic	TCF3	nonsynonymous	SKCM\|1\|368\|0.00272
rs372813564	chr19	1612273	1612273	C	T	exonic	TCF3	synonymous	ESCA\|1\|185\|0.00541
-	chr19	1615698	1615698	G	-	exonic	TCF3	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs746441572	chr19	1619335	1619335	C	T	exonic	TCF3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs142947854	chr19	1615741	1615741	C	T	exonic	TCF3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	1612270	1612270	C	A	exonic	TCF3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr19	1619835	1619835	G	A	exonic	TCF3	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	1615722	1615722	C	T	exonic	TCF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	1615524	1615524	G	A	intronic	TCF3	unknown	SKCM\|2\|368\|0.00543
-	chr19	1622363	1622363	G	A	exonic	TCF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	1612289	1612289	A	G	exonic	TCF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	1615435	1615435	C	T	exonic	TCF3	synonymous	BLCA\|1\|396\|0.00253
-	chr19	1615425	1615425	G	A	exonic	TCF3	nonsynonymous	BRCA\|1\|982\|0.00102
rs781162855	chr19	1615407	1615407	C	T	exonic	TCF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr19	1619821	1619821	G	-	exonic	TCF3	frameshift	ESCA\|1\|185\|0.00541
rs8140	chr19	1619339	1619339	T	C	exonic	TCF3	synonymous	ACC\|17\|90\|0.18889
-	chr19	1623982	1623982	C	A	exonic	TCF3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs1052692	chr19	1619350	1619350	C	T	exonic	TCF3	nonsynonymous	ACC\|4\|90\|0.04444
-	chr19	1612333	1612333	A	C	exonic	TCF3	nonsynonymous	TGCT\|1\|155\|0.00645
rs2240590	chr19	1622116	1622116	G	A	exonic	TCF3	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
rs148304557	chr19	1615419	1615419	G	A	exonic	TCF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs757137735	chr19	1615563	1615563	G	A	intronic	TCF3	unknown	SKCM\|1\|368\|0.00272
rs751889696	chr19	1632113	1632113	G	A	exonic	TCF3	synonymous	SKCM\|1\|368\|0.00272
rs372813564	chr19	1612273	1612273	C	A	exonic	TCF3	synonymous	LUAD\|1\|543\|0.00184
-	chr19	1615357	1615357	C	A	exonic	TCF3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr19	1632396	1632396	C	-	exonic	TCF3	frameshift	BRCA\|1\|982\|0.00102
rs759261756	chr19	1612283	1612283	G	A	exonic	TCF3	nonsynonymous	SKCM\|1\|368\|0.00272

Disease information of TCF3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TCF3	Agammaglobulinemia	C15;C20	Disease or Syndrome	CTD_human
TCF3	Burkitt Lymphoma	C02;C04;C15;C20	Neoplastic Process	CTD_human;ORPHANET
TCF3	Childhood Acute Lymphoblastic Leukemia	C04;C15;C20	Neoplastic Process	CTD_human
TCF3	Leukemia, Lymphocytic, Acute, L2	C04;C15;C20	Neoplastic Process	CTD_human
TCF3	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
TCF3	Hypogammaglobulinemia	C15;C20	Disease or Syndrome	CTD_human
TCF3	African Burkitt's lymphoma	C02;C04;C15;C20	Neoplastic Process	CTD_human
TCF3	Precursor B-cell lymphoblastic leukemia		Neoplastic Process	ORPHANET
TCF3	Colorectal Cancer	C04;C06	Neoplastic Process	UNIPROT
TCF3	Agammaglobulinemia, non-Bruton type	C15;C20	Disease or Syndrome	ORPHANET
TCF3	Precursor Cell Lymphoblastic Leukemia Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human

Pathway associated with TCF3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000393	CDO in myogenesis	reactome	29	200
pathway0001078	ID	netpath	38	213
pathway0001516	Notch-mediated HES/HEY network	pid	48	337
pathway0001574	p38 signaling mediated by MAPKAP kinases	pid	21	107

Go term information of TCF3

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GO_term_name	GO_term_type	TF_name
GO_LEUKOCYTE_ACTIVATION	BP	TCF3
GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	TCF3
GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION	BP	TCF3
GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS	BP	TCF3
GO_SOMATIC_CELL_DNA_RECOMBINATION	BP	TCF3
GO_LYMPHOCYTE_ACTIVATION	BP	TCF3
GO_IMMUNOGLOBULIN_PRODUCTION	BP	TCF3
GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION	BP	TCF3
GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS	BP	TCF3
GO_REGULATION_OF_B_CELL_PROLIFERATION	BP	TCF3
GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT	BP	TCF3
GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE	BP	TCF3
GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS	BP	TCF3
GO_LYMPHOCYTE_DIFFERENTIATION	BP	TCF3
GO_V_D_J_RECOMBINATION	BP	TCF3
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX	CC	TCF3
GO_NUCLEAR_CHROMATIN	CC	TCF3
GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX	CC	TCF3
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING	MF	TCF3
GO_E_BOX_BINDING	MF	TCF3
GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING	MF	TCF3
GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	TCF3

Survival analysis of TCF3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TCF3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)