Cancer CRCdb

TF information

TF name:	TBX5
TF family:	T-box
Ensembl gene ID:	ENSG00000089225
Ensembl protein ID:	ENSP00000384152, ENSP00000337723, ENSP00000309913, ENSP00000433292
Entrez gene ID:	6910

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TBX5 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_022	Cell line	Prostate	C4-2B	0.92857142857143

TBX5 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_022	Prostate	Cell line	C4-2B

TBX5 distribution in all CRCs

Genomic distribution of SEs associated with TBX5

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Mutation of TBX5

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TBX5

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr12	114803922	114803922	G	T	intronic	TBX5	unknown	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114841604	114841604	C	-	exonic	TBX5	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114832644	114832644	C	T	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114841616	114841616	T	C	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114804166	114804166	G	C	exonic	TBX5	synonymous	HNSC\|1\|512\|0.00195
-	chr12	114832691	114832691	A	T	exonic	TBX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	114836486	114836486	G	T	exonic	TBX5	synonymous	LUSC\|1\|178\|0.00562
-	chr12	114793417	114793417	C	A	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114823293	114823293	G	C	exonic	TBX5	stopgain	UVM\|1\|80\|0.01250
-	chr12	114837376	114837376	G	T	exonic	TBX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	114803995	114803995	T	G	exonic	TBX5	nonsynonymous	UCS\|1\|57\|0.01754
rs200354838	chr12	114793348	114793348	C	T	exonic	TBX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
rs200382742	chr12	114804183	114804183	C	T	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114793495	114793495	C	A	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114841665	114841665	C	T	exonic	TBX5	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506,UCEC\|1\|248\|0.00403
-	chr12	114832631	114832631	C	A	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114793736	114793736	G	-	exonic	TBX5	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs763827720	chr12	114793778	114793778	C	T	exonic	TBX5	synonymous	OV\|1\|469\|0.00213
-	chr12	114804147	114804147	A	T	exonic	TBX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	114836517	114836517	G	-	exonic	TBX5	frameshift	LUAD\|1\|543\|0.00184
-	chr12	114841721	114841721	G	A	UTR5	TBX5	unknown	BRCA\|1\|982\|0.00102
-	chr12	114804186	114804186	G	A	exonic	TBX5	nonsynonymous	UCEC\|1\|248\|0.00403
rs760177359	chr12	114804111	114804111	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
rs483353129	chr12	114837342	114837342	C	T	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
rs374924325	chr12	114793375	114793375	C	T	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114803975	114803975	C	T	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
rs200326827	chr12	114832597	114832597	G	A	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
rs753688559	chr12	114793733	114793733	G	T	exonic	TBX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	114841672	114841672	G	A	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114793542	114793542	C	G	exonic	TBX5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	114793370	114793370	A	C	exonic	TBX5	synonymous	LIHC\|1\|373\|0.00268
-	chr12	114837370	114837370	T	C	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114793906	114793906	C	A	exonic	TBX5	stopgain	UCEC\|1\|248\|0.00403
-	chr12	114793441	114793441	G	A	exonic	TBX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	114841627	114841627	G	A	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr12	114832685	114832685	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114793788	114793788	C	T	exonic	TBX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	114804033	114804033	G	T	exonic	TBX5	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	114837435	114837435	C	T	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114793430	114793430	G	T	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	114793855	114793855	G	C	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114793439	114793439	-	G	exonic	TBX5	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114793454	114793454	G	A	exonic	TBX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs145784562	chr12	114793830	114793830	C	A	exonic	TBX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	114793514	114793514	G	T	exonic	TBX5	synonymous	ACC\|1\|90\|0.01111
rs765999767	chr12	114836479	114836479	C	T	exonic	TBX5	nonsynonymous	TGCT\|1\|155\|0.00645
rs769107196	chr12	114841727	114841727	G	A	UTR5	TBX5	unknown	ESCA\|1\|185\|0.00541
rs557758851	chr12	114793581	114793581	C	T	exonic	TBX5	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	114837405	114837405	G	T	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs114124210	chr12	114793660	114793660	C	T	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114841592	114841592	A	G	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs769736865	chr12	114837386	114837386	C	T	exonic	TBX5	synonymous	LUSC\|1\|178\|0.00562
rs767955877	chr12	114793376	114793376	G	A	exonic	TBX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs143068551	chr12	114793779	114793779	G	A	exonic	TBX5	nonsynonymous	BLCA\|1\|396\|0.00253,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114793393	114793393	G	C	exonic	TBX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	114803929	114803929	G	T	intronic	TBX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	114793645	114793645	G	A	exonic	TBX5	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	114823354	114823354	C	A	exonic	TBX5	stopgain	LUSC\|1\|178\|0.00562
-	chr12	114836488	114836488	G	A	exonic	TBX5	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr12	114793673	114793673	G	T	exonic	TBX5	stopgain	LUAD\|2\|543\|0.00368
-	chr12	114836398	114836398	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114793895	114793895	G	T	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	114836387	114836387	T	G	exonic	TBX5	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs757457183	chr12	114793494	114793494	A	G	exonic	TBX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	114832619	114832619	T	C	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114823344	114823344	G	T	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114836427	114836427	G	A	exonic	TBX5	nonsynonymous	BLCA\|1\|396\|0.00253
rs556197042	chr12	114793417	114793417	C	T	exonic	TBX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	114836423	114836423	G	T	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs767487291	chr12	114841689	114841689	G	A	exonic	TBX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs745378130	chr12	114832645	114832645	C	T	exonic	TBX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	114803908	114803908	C	G	intronic	TBX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	114839701	114839701	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114793460	114793460	G	A	exonic	TBX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	114803965	114803965	C	A	intronic	TBX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	114793765	114793765	C	T	exonic	TBX5	nonsynonymous	THCA\|1\|504\|0.00198
-	chr12	114804106	114804106	G	T	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	114793374	114793374	C	A	exonic	TBX5	nonsynonymous	SARC\|1\|247\|0.00405
-	chr12	114793507	114793507	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114803998	114803998	G	T	exonic	TBX5	nonsynonymous	ESCA\|1\|185\|0.00541,UCEC\|1\|248\|0.00403
-	chr12	114793770	114793770	C	A	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114803999	114803999	C	T	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114793544	114793544	C	T	exonic	TBX5	synonymous	OV\|1\|469\|0.00213
-	chr12	114804192	114804192	-	A	exonic	TBX5	stopgain	BRCA\|1\|982\|0.00102,UCEC\|2\|248\|0.00806
-	chr12	114803928	114803928	G	T	intronic	TBX5	unknown	LUAD\|1\|543\|0.00184
-	chr12	114823305	114823305	A	G	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114823291	114823291	T	G	exonic	TBX5	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr12	114793477	114793477	G	C	exonic	TBX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	114832695	114832695	T	A	exonic	TBX5	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	114841708	114841708	C	T	UTR5	TBX5	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs142293206	chr12	114836513	114836513	G	A	exonic	TBX5	synonymous	LUSC\|1\|178\|0.00562
-	chr12	114836398	114836398	G	C	exonic	TBX5	nonsynonymous	ESCA\|2\|185\|0.01081
-	chr12	114804198	114804198	T	A	splicing	TBX5	splicing	LUAD\|1\|543\|0.00184
rs575701831	chr12	114803958	114803958	G	A	intronic	TBX5	unknown	SKCM\|1\|368\|0.00272
-	chr12	114841573	114841573	G	A	exonic	TBX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	114793360	114793360	G	T	exonic	TBX5	nonsynonymous	ACC\|1\|90\|0.01111
-	chr12	114803961	114803961	C	T	intronic	TBX5	unknown	UCEC\|1\|248\|0.00403
-	chr12	114841655	114841655	G	T	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114836499	114836499	G	A	exonic	TBX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	114837335	114837335	T	A	exonic	TBX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	114841585	114841585	G	A	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114839711	114839711	G	C	exonic	TBX5	nonsynonymous	HNSC\|1\|512\|0.00195
rs746284842	chr12	114841632	114841632	G	A	exonic	TBX5	synonymous	PRAD\|1\|499\|0.00200
-	chr12	114832700	114832700	T	C	splicing	TBX5	splicing	UCEC\|1\|248\|0.00403
-	chr12	114793472	114793472	A	C	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
rs557183241	chr12	114832653	114832653	C	T	exonic	TBX5	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr12	114793746	114793746	G	C	exonic	TBX5	nonsynonymous	BRCA\|1\|982\|0.00102
rs374906778	chr12	114836461	114836461	C	T	exonic	TBX5	nonsynonymous	SARC\|1\|247\|0.00405
-	chr12	114793760	114793760	G	T	exonic	TBX5	stopgain	LUAD\|1\|543\|0.00184
-	chr12	114793739	114793739	G	T	exonic	TBX5	synonymous	HNSC\|1\|512\|0.00195
rs149030937	chr12	114841587	114841587	C	T	exonic	TBX5	synonymous	LUSC\|1\|178\|0.00562
-	chr12	114793480	114793480	G	T	exonic	TBX5	nonsynonymous	ESCA\|1\|185\|0.00541
rs188839350	chr12	114793661	114793661	G	A	exonic	TBX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	114793644	114793644	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114803991	114803991	A	C	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114841557	114841557	C	T	exonic	TBX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	114793706	114793706	G	A	exonic	TBX5	synonymous	BLCA\|1\|396\|0.00253
-	chr12	114836450	114836450	C	T	exonic	TBX5	synonymous	UCEC\|1\|248\|0.00403
-	chr12	114836395	114836395	G	A	exonic	TBX5	synonymous	BLCA\|1\|396\|0.00253
rs376519728	chr12	114823367	114823367	C	T	exonic	TBX5	synonymous	BLCA\|1\|396\|0.00253,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114832660	114832660	T	C	exonic	TBX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114841649	114841649	C	T	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114793616	114793616	G	T	exonic	TBX5	nonsynonymous	CESC\|1\|194\|0.00515
-	chr12	114841688	114841688	C	A	exonic	TBX5	stopgain	LUAD\|1\|543\|0.00184
-	chr12	114793686	114793686	C	T	exonic	TBX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	114841671	114841671	C	T	exonic	TBX5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	114804092	114804092	A	G	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114823290	114823290	C	A	exonic	TBX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	114841626	114841626	C	T	exonic	TBX5	synonymous	UCEC\|2\|248\|0.00806
-	chr12	114823345	114823345	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114837332	114837332	G	A	exonic	TBX5	synonymous	SKCM\|1\|368\|0.00272
-	chr12	114793647	114793647	T	A	exonic	TBX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	114804148	114804148	G	T	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	114793517	114793517	G	T	exonic	TBX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114793425	114793425	G	C	exonic	TBX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	114837439	114837439	T	G	splicing	TBX5	splicing	HNSC\|1\|512\|0.00195
-	chr12	114823291	114823291	T	C	exonic	TBX5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	114793594	114793594	G	A	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114804048	114804048	G	T	exonic	TBX5	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs139329918	chr12	114832609	114832609	C	T	exonic	TBX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	114793735	114793735	-	G	exonic	TBX5	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr12	114803972	114803972	T	G	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114836449	114836449	G	T	exonic	TBX5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	114793396	114793396	G	A	exonic	TBX5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	114804053	114804053	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114837318	114837318	C	T	exonic	TBX5	stopgain	LUAD\|1\|543\|0.00184
-	chr12	114793599	114793599	G	A	exonic	TBX5	nonsynonymous	BLCA\|1\|396\|0.00253,BRCA\|1\|982\|0.00102,SARC\|1\|247\|0.00405,UCEC\|1\|248\|0.00403
-	chr12	114804031	114804031	T	A	exonic	TBX5	synonymous	BRCA\|1\|982\|0.00102
-	chr12	114793709	114793709	G	A	exonic	TBX5	synonymous	OV\|1\|469\|0.00213
-	chr12	114793313	114793313	G	A	UTR3	TBX5	unknown	UCEC\|1\|248\|0.00403
-	chr12	114804065	114804065	C	A	exonic	TBX5	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	114793888	114793888	G	A	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114832641	114832641	C	A	exonic	TBX5	stopgain	UCS\|1\|57\|0.01754
-	chr12	114832616	114832616	T	-	exonic	TBX5	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114793522	114793522	G	T	exonic	TBX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	114804101	114804101	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114804114	114804114	C	T	exonic	TBX5	nonsynonymous	LUAD\|6\|543\|0.01105
-	chr12	114839668	114839668	C	T	exonic	TBX5	nonsynonymous	BLCA\|1\|396\|0.00253,PAAD\|1\|185\|0.00541
-	chr12	114841566	114841566	G	A	exonic	TBX5	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	114841666	114841666	G	A	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114836462	114836462	G	-	exonic	TBX5	frameshift	BLCA\|1\|396\|0.00253
rs368563052	chr12	114823313	114823313	G	A	exonic	TBX5	synonymous	BLCA\|1\|396\|0.00253
-	chr12	114832618	114832618	T	G	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114793477	114793477	G	T	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	114793577	114793577	C	G	exonic	TBX5	synonymous	LUAD\|2\|543\|0.00368
-	chr12	114823367	114823367	C	A	exonic	TBX5	synonymous	LIHC\|1\|373\|0.00268,LUAD\|1\|543\|0.00184
-	chr12	114793500	114793500	G	A	exonic	TBX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	114793419	114793419	C	T	exonic	TBX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	114837434	114837434	C	A	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	114804159	114804159	G	T	exonic	TBX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs770274405	chr12	114832669	114832669	C	T	exonic	TBX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114832691	114832691	A	G	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs377532269	chr12	114793771	114793771	G	A	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213,SARC\|1\|247\|0.00405,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114836462	114836462	G	A	exonic	TBX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114793421	114793421	A	G	exonic	TBX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs146038442	chr12	114836456	114836456	G	A	exonic	TBX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs145365553	chr12	114841688	114841688	C	T	exonic	TBX5	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	114793871	114793871	G	T	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	114793650	114793650	A	G	exonic	TBX5	nonsynonymous	LIHC\|1\|373\|0.00268
rs369034176	chr12	114793418	114793418	G	A	exonic	TBX5	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	114793595	114793595	C	-	exonic	TBX5	frameshift	ESCA\|1\|185\|0.00541
-	chr12	114793414	114793414	G	A	exonic	TBX5	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr12	114793463	114793463	C	T	exonic	TBX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	114839706	114839706	A	G	exonic	TBX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	114804095	114804095	T	A	exonic	TBX5	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr12	114793838	114793838	G	T	exonic	TBX5	synonymous	LUAD\|1\|543\|0.00184
-	chr12	114836427	114836427	G	C	exonic	TBX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	114823299	114823299	C	A	exonic	TBX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	114836499	114836499	G	T	exonic	TBX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	114793522	114793522	G	C	exonic	TBX5	nonsynonymous	LUAD\|2\|543\|0.00368
rs369697961	chr12	114804123	114804123	C	T	exonic	TBX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	114841604	114841604	C	G	exonic	TBX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of TBX5

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TBX5	Polydactyly	C05;C16	Congenital Abnormality	GENOMICS_ENGLAND
TBX5	Wildervanck's syndrome	C05;C14;C16	Disease or Syndrome	CTD_human
TBX5	Holt-Oram syndrome	C05;C14;C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
TBX5	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
TBX5	Radial club hand		Congenital Abnormality	GENOMICS_ENGLAND

Pathway associated with TBX5

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001649	Physiological factors	reactome	12	24
pathway0002460	YAP1- and WWTR1 (TAZ)-stimulated gene expression	reactome	29	144
pathway0002768	Hs_Heart_Development_WP1591_90186	wikipathways	28	78

Go term information of TBX5

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GO_term_name	GO_term_type	TF_name
GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT	BP	TBX5
GO_CARDIAC_SEPTUM_DEVELOPMENT	BP	TBX5
GO_CORONARY_VASCULATURE_DEVELOPMENT	BP	TBX5
GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX5
GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS	BP	TBX5
GO_CARDIAC_CHAMBER_MORPHOGENESIS	BP	TBX5
GO_ENDOCARDIAL_CUSHION_DEVELOPMENT	BP	TBX5
GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	TBX5
GO_NEGATIVE_REGULATION_OF_LOCOMOTION	BP	TBX5
GO_POSITIVE_REGULATION_OF_HEART_GROWTH	BP	TBX5
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	TBX5
GO_FORELIMB_MORPHOGENESIS	BP	TBX5
GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION	BP	TBX5
GO_REGULATION_OF_ORGAN_FORMATION	BP	TBX5
GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT	BP	TBX5
GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH	BP	TBX5
GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH	BP	TBX5
GO_CARDIAC_ATRIUM_DEVELOPMENT	BP	TBX5
GO_ATRIAL_SEPTUM_DEVELOPMENT	BP	TBX5
GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX5
GO_ATRIAL_SEPTUM_MORPHOGENESIS	BP	TBX5
GO_EMBRYONIC_FORELIMB_MORPHOGENESIS	BP	TBX5
GO_REGULATION_OF_HEART_MORPHOGENESIS	BP	TBX5
GO_CARDIAC_VENTRICLE_MORPHOGENESIS	BP	TBX5
GO_ORGAN_MORPHOGENESIS	BP	TBX5
GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	TBX5
GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	TBX5
GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX5
GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	TBX5
GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH	BP	TBX5
GO_EMBRYONIC_MORPHOGENESIS	BP	TBX5
GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX5
GO_VENTRICULAR_SEPTUM_DEVELOPMENT	BP	TBX5
GO_VASCULOGENESIS	BP	TBX5
GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION	BP	TBX5
GO_CARDIOCYTE_DIFFERENTIATION	BP	TBX5
GO_PERICARDIUM_DEVELOPMENT	BP	TBX5
GO_HEART_VALVE_DEVELOPMENT	BP	TBX5
GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS	BP	TBX5
GO_RESPIRATORY_SYSTEM_DEVELOPMENT	BP	TBX5
GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX5
GO_REGULATION_OF_HEART_GROWTH	BP	TBX5
GO_CARDIAC_CHAMBER_FORMATION	BP	TBX5
GO_CARDIAC_SEPTUM_MORPHOGENESIS	BP	TBX5
GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	TBX5
GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT	BP	TBX5
GO_MUSCLE_CELL_DIFFERENTIATION	BP	TBX5
GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS	BP	TBX5
GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH	BP	TBX5
GO_NEGATIVE_REGULATION_OF_HEART_GROWTH	BP	TBX5
GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS	BP	TBX5
GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	TBX5

Survival analysis of TBX5

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TBX5

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)