Cancer CRCdb

TF information

TF name:	RXRB
TF family:	RXR-like
Ensembl gene ID:	ENSG00000204231
Ensembl protein ID:	ENSP00000363817, ENSP00000363812
Entrez gene ID:	6257

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of RXRB in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.20588235294118

RXRB distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

RXRB distribution in all CRCs

Genomic distribution of SEs associated with RXRB

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Mutation of RXRB

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of RXRB

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs775663382	chr6	33168217	33168217	G	A	exonic	RXRB	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	33163373	33163373	T	C	exonic	RXRB	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	33164323	33164323	C	G	exonic	RXRB	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	33163388	33163388	G	A	exonic	RXRB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33165608	33165608	T	C	exonic	RXRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	33165552	33165552	G	A	exonic	RXRB	synonymous	BLCA\|1\|396\|0.00253
-	chr6	33164330	33164330	C	A	exonic	RXRB	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	33165605	33165605	G	A	exonic	RXRB	nonsynonymous	OV\|1\|469\|0.00213
-	chr6	33162790	33162790	G	A	exonic	RXRB	synonymous	SARC\|1\|247\|0.00405
-	chr6	33164164	33164164	C	-	intronic	RXRB	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33168158	33168158	G	A	exonic	RXRB	synonymous	CESC\|1\|194\|0.00515
-	chr6	33168094	33168094	C	-	exonic	RXRB	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	33167028	33167028	G	A	exonic	RXRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	33163791	33163791	A	C	exonic	RXRB	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	33162460	33162460	C	T	exonic	RXRB	synonymous	CESC\|1\|194\|0.00515
-	chr6	33164323	33164323	C	-	exonic	RXRB	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33162542	33162542	G	-	exonic	RXRB	frameshift	SKCM\|1\|368\|0.00272
-	chr6	33168031	33168031	C	T	exonic	RXRB	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	33162510	33162510	G	-	exonic	RXRB	frameshift	LUAD\|1\|543\|0.00184
-	chr6	33164153	33164153	C	A	intronic	RXRB	unknown	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	33166198	33166198	G	-	exonic	RXRB	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LIHC\|2\|373\|0.00536
-	chr6	33165572	33165572	G	A	exonic	RXRB	stopgain	HNSC\|1\|512\|0.00195
-	chr6	33165668	33165668	G	A	exonic	RXRB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	33165606	33165606	C	T	exonic	RXRB	synonymous	OV\|1\|469\|0.00213
-	chr6	33165653	33165653	C	A	exonic	RXRB	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	33166204	33166204	C	-	exonic	RXRB	frameshift	BRCA\|1\|982\|0.00102
-	chr6	33162525	33162525	G	A	exonic	RXRB	synonymous	BLCA\|1\|396\|0.00253
-	chr6	33163374	33163374	G	A	exonic	RXRB	nonsynonymous	OV\|1\|469\|0.00213
-	chr6	33163691	33163691	C	T	exonic	RXRB	synonymous	HNSC\|1\|512\|0.00195
-	chr6	33166204	33166204	C	G	exonic	RXRB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33164130	33164130	G	-	intronic	RXRB	unknown	ESCA\|1\|185\|0.00541
-	chr6	33162825	33162825	C	T	exonic	RXRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	33163160	33163160	G	A	exonic	RXRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	33164363	33164363	G	A	exonic	RXRB	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr6	33168099	33168099	G	A	exonic	RXRB	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	33164323	33164323	C	T	exonic	RXRB	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	33165574	33165574	T	C	exonic	RXRB	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	33164224	33164224	C	-	exonic	RXRB	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|4\|543\|0.00737
-	chr6	33163381	33163381	C	T	exonic	RXRB	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	33166144	33166144	G	-	exonic	RXRB	frameshift	LIHC\|1\|373\|0.00268
-	chr6	33162491	33162491	C	A	exonic	RXRB	stopgain	LIHC\|1\|373\|0.00268
-	chr6	33163700	33163700	G	A	exonic	RXRB	synonymous	SKCM\|1\|368\|0.00272
-	chr6	33162585	33162585	A	G	exonic	RXRB	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	33164382	33164382	C	A	exonic	RXRB	synonymous	ACC\|1\|90\|0.01111
-	chr6	33166123	33166123	C	T	exonic	RXRB	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,PAAD\|1\|185\|0.00541
-	chr6	33168121	33168121	G	A	exonic	RXRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	33166234	33166234	G	C	exonic	RXRB	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33166241	33166241	T	A	exonic	RXRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	33166143	33166143	-	G	exonic	RXRB	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33163152	33163152	G	C	exonic	RXRB	nonsynonymous	BLCA\|1\|396\|0.00253
rs61730281	chr6	33166101	33166101	G	A	exonic	RXRB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs763483233	chr6	33162723	33162723	G	A	exonic	RXRB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33162787	33162787	C	T	exonic	RXRB	synonymous	UCEC\|1\|248\|0.00403
-	chr6	33165612	33165612	C	T	exonic	RXRB	synonymous	LUAD\|2\|543\|0.00368
-	chr6	33163151	33163151	A	G	exonic	RXRB	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr6	33168220	33168220	G	A	exonic	RXRB	stopgain	BLCA\|1\|396\|0.00253
-	chr6	33165658	33165658	C	T	exonic	RXRB	nonsynonymous	PRAD\|2\|499\|0.00401
-	chr6	33164069	33164069	G	A	intronic	RXRB	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	33165597	33165597	C	T	exonic	RXRB	synonymous	BLCA\|1\|396\|0.00253
-	chr6	33162507	33162507	G	A	exonic	RXRB	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,DLBC\|1\|48\|0.02083
-	chr6	33164232	33164232	-	C	exonic	RXRB	frameshift	LIHC\|1\|373\|0.00268
-	chr6	33166996	33166996	G	C	exonic	RXRB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	33166144	33166144	G	A	exonic	RXRB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	33162736	33162736	A	G	exonic	RXRB	synonymous	LIHC\|1\|373\|0.00268
-	chr6	33168113	33168113	C	T	exonic	RXRB	synonymous	PRAD\|1\|499\|0.00200
-	chr6	33163416	33163416	A	G	exonic	RXRB	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	33165642	33165642	G	A	exonic	RXRB	synonymous	HNSC\|1\|512\|0.00195
-	chr6	33164069	33164069	G	C	intronic	RXRB	unknown	BLCA\|1\|396\|0.00253
-	chr6	33164342	33164342	C	-	exonic	RXRB	frameshift	LIHC\|1\|373\|0.00268

Disease information of RXRB

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
RXRB	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
RXRB	Malignant neoplasm of stomach	C04;C06	Neoplastic Process	CTD_human
RXRB	Stomach Neoplasms	C04;C06	Neoplastic Process	CTD_human
RXRB	Disease Exacerbation	C23	Finding	CTD_human
RXRB	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
RXRB	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
RXRB	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
RXRB	Hereditary Diffuse Gastric Cancer	C04;C06	Neoplastic Process	CTD_human

Pathway associated with RXRB

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000044	a6b1 and a6b4 Integrin signaling	pid	46	383
pathway0001825	Regulation of Androgen receptor activity	pid	54	338
pathway0001883	Retinoic acid receptors-mediated signaling	pid	30	235
pathway0001947	RXR and RAR heterodimerization with other nuclear receptor	pid	26	164
pathway0002028	Signaling by Retinoic Acid	reactome	20	78
pathway0002561	PPAR signaling pathway	kegg	67	520
pathway0002628	Adipocytokine signaling pathway	kegg	65	539
pathway0002663	Thyroid cancer	kegg	25	123
pathway0002669	Small cell lung cancer	kegg	83	807
pathway0002670	Non-small cell lung cancer	kegg	54	623

Go term information of RXRB

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_RECEPTOR_ACTIVITY	BP	RXRB
GO_REGULATION_OF_MYELINATION	BP	RXRB
GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT	BP	RXRB
GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY	BP	RXRB
GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	RXRB
GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS	BP	RXRB
GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY	BP	RXRB
GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY	BP	RXRB
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	RXRB
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY	MF	RXRB
GO_VITAMIN_D_RECEPTOR_BINDING	MF	RXRB
GO_RECEPTOR_ACTIVATOR_ACTIVITY	MF	RXRB
GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	MF	RXRB
GO_RETINOIC_ACID_RECEPTOR_BINDING	MF	RXRB
GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	RXRB
GO_THYROID_HORMONE_RECEPTOR_BINDING	MF	RXRB
GO_RECEPTOR_REGULATOR_ACTIVITY	MF	RXRB

Survival analysis of RXRB

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of RXRB

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)