Cancer CRCdb

TF information

TF name:	PAX6
TF family:	PAX
Ensembl gene ID:	ENSG00000007372
Ensembl protein ID:	ENSP00000492316, ENSP00000491862, ENSP00000492808, ENSP00000492024, ENSP00000490971, ENSP00000492129, ENSP00000491295, ENSP00000491517, ENSP00000492205, ENSP00000492658, ENSP00000368406, ENSP00000492397, ENSP00000492166, ENSP00000388132, ENSP00000368410, ENSP00000491872
Entrez gene ID:	5080

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of PAX6 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_413	Tissue	Brain	GBM_2493	0.45604395604396

PAX6 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

PAX6 distribution in all CRCs

Genomic distribution of SEs associated with PAX6

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Mutation of PAX6

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of PAX6

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr11	31816333	31816333	C	A	exonic	PAX6	nonsynonymous	OV\|1\|469\|0.00213
-	chr11	31823248	31823248	C	A	exonic	PAX6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	31824265	31824265	G	A	exonic	PAX6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31823124	31823124	G	A	exonic	PAX6	synonymous	PAAD\|1\|185\|0.00541
-	chr11	31812409	31812409	C	A	splicing	PAX6	splicing	UCEC\|1\|248\|0.00403
rs1800427	chr11	31822342	31822342	G	A	exonic	PAX6	synonymous	ESCA\|1\|185\|0.00541
rs746448834	chr11	31823152	31823152	C	A	exonic	PAX6	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr11	31823109	31823109	G	A	exonic	PAX6	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31822371	31822371	C	T	exonic	PAX6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	31815651	31815651	T	C	exonic	PAX6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	31815228	31815228	G	T	exonic	PAX6	stopgain	LUAD\|1\|543\|0.00184
-	chr11	31827048	31827048	G	T	intronic	PAX6	unknown	ESCA\|1\|185\|0.00541
-	chr11	31823145	31823145	C	A	exonic	PAX6	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31816201	31816201	T	C	exonic	PAX6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	31824271	31824271	T	A	exonic	PAX6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31812409	31812409	C	T	splicing	PAX6	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs200959420	chr11	31812346	31812346	A	G	exonic	PAX6	synonymous	SKCM\|1\|368\|0.00272
-	chr11	31812340	31812340	C	A	exonic	PAX6	synonymous	LUAD\|1\|543\|0.00184
-	chr11	31822330	31822330	A	G	exonic	PAX6	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31815051	31815051	T	G	exonic	PAX6	nonsynonymous	LUAD\|1\|543\|0.00184
rs755528147	chr11	31815029	31815029	G	A	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31815066	31815066	T	C	exonic	PAX6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	31822358	31822358	T	C	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31811520	31811520	C	A	exonic	PAX6	stopgain	BLCA\|1\|396\|0.00253
-	chr11	31816191	31816191	C	A	exonic	PAX6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	31812271	31812271	G	T	exonic	PAX6	synonymous	LUSC\|1\|178\|0.00562
-	chr11	31815208	31815208	G	A	exonic	PAX6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	31815294	31815294	C	T	exonic	PAX6	synonymous	PRAD\|1\|499\|0.00200
-	chr11	31824337	31824337	C	A	exonic	PAX6	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr11	31822268	31822268	C	A	exonic	PAX6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31815030	31815030	G	A	exonic	PAX6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs369447790	chr11	31812352	31812352	C	T	exonic	PAX6	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr11	31811521	31811521	A	G	exonic	PAX6	synonymous	LUAD\|1\|543\|0.00184
-	chr11	31824329	31824329	G	A	exonic	PAX6	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr11	31815103	31815103	T	A	splicing	PAX6	splicing	LUAD\|1\|543\|0.00184
-	chr11	31823240	31823240	G	A	exonic	PAX6	nonsynonymous	SARC\|1\|247\|0.00405
-	chr11	31812317	31812317	G	-	exonic	PAX6	frameshift	BRCA\|1\|982\|0.00102,COAD\|4\|367\|0.01090,COADREAD\|4\|489\|0.00818,PAAD\|1\|185\|0.00541,STAD\|11\|395\|0.02785,STES\|11\|395\|0.02785
-	chr11	31822244	31822244	G	A	exonic	PAX6	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr11	31824298	31824298	A	G	exonic	PAX6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31815069	31815069	G	A	exonic	PAX6	stopgain	ESCA\|1\|185\|0.00541,PRAD\|1\|499\|0.00200
-	chr11	31816305	31816305	C	T	exonic	PAX6	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr11	31823222	31823222	C	T	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31815292	31815292	C	A	exonic	PAX6	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr11	31816309	31816309	C	T	exonic	PAX6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	31823446	31823446	T	A	exonic	PAX6	synonymous	BLCA\|2\|396\|0.00505
-	chr11	31815038	31815038	C	T	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31815653	31815653	C	A	exonic	PAX6	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr11	31815341	31815341	A	G	exonic	PAX6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	31822324	31822324	T	C	exonic	PAX6	synonymous	UCEC\|1\|248\|0.00403
-	chr11	31823285	31823286	AA	-	exonic	PAX6	frameshift	BRCA\|1\|982\|0.00102
rs121907928	chr11	31823109	31823109	G	T	exonic	PAX6	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr11	31815003	31815003	T	C	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31823216	31823216	C	A	exonic	PAX6	nonsynonymous	HNSC\|2\|512\|0.00391
rs776244636	chr11	31811563	31811563	G	T	exonic	PAX6	synonymous	LUAD\|1\|543\|0.00184
-	chr11	31815604	31815604	T	-	exonic	PAX6	frameshift	LUAD\|1\|543\|0.00184
-	chr11	31822286	31822286	C	T	exonic	PAX6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31832564	31832564	C	A	splicing	PAX6	splicing	UCEC\|1\|248\|0.00403
rs367589686	chr11	31816281	31816281	G	A	exonic	PAX6	synonymous	BRCA\|1\|982\|0.00102,HNSC\|1\|512\|0.00195
-	chr11	31823241	31823241	T	C	exonic	PAX6	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31823272	31823272	G	T	exonic	PAX6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	31816322	31816322	G	T	exonic	PAX6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	31816274	31816274	C	A	exonic	PAX6	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr11	31815215	31815215	G	A	exonic	PAX6	stopgain	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs766564648	chr11	31816185	31816185	C	T	exonic	PAX6	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31815288	31815288	T	C	exonic	PAX6	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31816307	31816307	C	G	exonic	PAX6	nonsynonymous	CESC\|1\|194\|0.00515,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31812394	31812394	G	C	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31822284	31822284	G	C	exonic	PAX6	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr11	31812322	31812322	G	T	exonic	PAX6	synonymous	LUAD\|1\|543\|0.00184
rs758400541	chr11	31822302	31822302	C	T	exonic	PAX6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31823250	31823250	A	G	exonic	PAX6	synonymous	UCEC\|1\|248\|0.00403
-	chr11	31815649	31815649	G	T	exonic	PAX6	synonymous	LUSC\|1\|178\|0.00562
rs777250095	chr11	31822341	31822341	C	T	exonic	PAX6	nonsynonymous	LUAD\|1\|543\|0.00184,UCEC\|1\|248\|0.00403
rs756801119	chr11	31812316	31812316	-	G	exonic	PAX6	frameshift	BRCA\|1\|982\|0.00102,COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613,KIPAN\|8\|799\|0.01001,KIRC\|8\|451\|0.01774,LUAD\|5\|543\|0.00921,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr11	31815594	31815594	C	T	exonic	PAX6	nonsynonymous	SKCM\|1\|368\|0.00272
rs759557055	chr11	31823252	31823252	C	T	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31812281	31812281	C	T	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31824263	31824263	G	A	exonic	PAX6	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31822388	31822388	C	A	exonic	PAX6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	31824340	31824340	C	A	exonic	PAX6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	31816277	31816277	C	T	exonic	PAX6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	31815663	31815663	C	A	splicing	PAX6	splicing	UCEC\|1\|248\|0.00403
-	chr11	31812372	31812372	T	A	exonic	PAX6	nonsynonymous	LUAD\|1\|543\|0.00184
rs747357950	chr11	31823185	31823185	C	T	exonic	PAX6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	31822335	31822335	A	G	exonic	PAX6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	31815095	31815095	G	A	exonic	PAX6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	31815586	31815586	T	C	exonic	PAX6	synonymous	OV\|1\|469\|0.00213
-	chr11	31816308	31816308	T	C	exonic	PAX6	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,TGCT\|1\|155\|0.00645
-	chr11	31824258	31824258	A	T	exonic	PAX6	synonymous	BLCA\|1\|396\|0.00253
-	chr11	31815103	31815103	T	C	splicing	PAX6	splicing	UCEC\|1\|248\|0.00403
-	chr11	31815013	31815013	G	A	exonic	PAX6	synonymous	LUAD\|1\|543\|0.00184
-	chr11	31822359	31822359	G	C	exonic	PAX6	nonsynonymous	OV\|1\|469\|0.00213
-	chr11	31822365	31822365	C	T	exonic	PAX6	nonsynonymous	UCEC\|1\|248\|0.00403
rs748252607	chr11	31823198	31823198	A	G	exonic	PAX6	nonsynonymous	CHOL\|1\|35\|0.02857
-	chr11	31823165	31823165	C	T	exonic	PAX6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	31823443	31823443	T	C	exonic	PAX6	synonymous	LUAD\|1\|543\|0.00184

Disease information of PAX6

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
PAX6	Alloxan Diabetes	C18;C19	Experimental Model of Disease	CTD_human
PAX6	Aniridia	C11;C16	Congenital Abnormality	CTD_human;ORPHANET;UNIPROT
PAX6	Ataxias, Hereditary	C10;C16	Disease or Syndrome	GENOMICS_ENGLAND
PAX6	Autistic Disorder	F03	Mental or Behavioral Dysfunction	CTD_human
PAX6	Congenital ocular coloboma (disorder)	C11;C16	Congenital Abnormality	GENOMICS_ENGLAND;UNIPROT
PAX6	Diabetes Mellitus, Experimental	C18;C19	Experimental Model of Disease	CTD_human
PAX6	Diabetes Mellitus, Non-Insulin-Dependent	C18;C19	Disease or Syndrome	CTD_human
PAX6	Profound Mental Retardation	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
PAX6	Malignant neoplasm of stomach	C04;C06	Neoplastic Process	CTD_human
PAX6	melanoma	C04	Neoplastic Process	CTD_human
PAX6	Mental Retardation, Psychosocial	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
PAX6	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
PAX6	Disorder of the optic nerve	C10;C11	Disease or Syndrome	CTD_human
PAX6	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
PAX6	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
PAX6	Disorders of Sex Development	C12;C13;C16;C19	Congenital Abnormality	GENOMICS_ENGLAND
PAX6	Stomach Neoplasms	C04;C06	Neoplastic Process	CTD_human
PAX6	Streptozotocin Diabetes	C18;C19	Experimental Model of Disease	CTD_human
PAX6	Tooth Abnormalities	C07;C16	Anatomical Abnormality	CTD_human
PAX6	Cataract	C11	Acquired Abnormality	GENOMICS_ENGLAND
PAX6	Foster-Kennedy Syndrome	C10;C11	Disease or Syndrome	CTD_human
PAX6	Coloboma of optic disc	C11;C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
PAX6	WAGR Syndrome	C04;C10;C11;C12;C13;C16;C19	Disease or Syndrome	CTD_human;ORPHANET
PAX6	Cranioschisis	C10;C16	Congenital Abnormality	CTD_human
PAX6	Congenital coloboma of iris		Congenital Abnormality	ORPHANET
PAX6	Hypoplasia of the optic nerve		Disease or Syndrome	ORPHANET
PAX6	Coloboma of lens		Congenital Abnormality	ORPHANET
PAX6	Irido-corneo-trabecular dysgenesis (disorder)	C11;C16	Congenital Abnormality	CTD_human;ORPHANET
PAX6	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
PAX6	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
PAX6	Gillespie syndrome	C10;C11;C16;C23;F01;F03	Disease or Syndrome	CTD_human;ORPHANET
PAX6	Congenital neurologic anomalies	C10;C16	Congenital Abnormality	CTD_human
PAX6	Coloboma of eyelid		Disease or Syndrome	ORPHANET
PAX6	Odontome	C07;C16	Congenital Abnormality	CTD_human
PAX6	Morning glory syndrome		Disease or Syndrome	ORPHANET
PAX6	Optic Disk Disorders	C10;C11	Disease or Syndrome	CTD_human
PAX6	Mental deficiency	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
PAX6	Hereditary Diffuse Gastric Cancer	C04;C06	Neoplastic Process	CTD_human
PAX6	Optic Nerve Hypoplasia, Bilateral	C10;C11	Disease or Syndrome	CTD_human;UNIPROT
PAX6	Optic Nerve Aplasia, Bilateral	C10;C11	Disease or Syndrome	UNIPROT
PAX6	Keratitis, hereditary	C11	Disease or Syndrome	CTD_human;ORPHANET
PAX6	Hereditary macular coloboma	C11;C16	Congenital Abnormality	ORPHANET
PAX6	Abnormality of the cornea		Finding	GENOMICS_ENGLAND
PAX6	O'Donnell Pappas syndrome	C10;C11;C16	Disease or Syndrome	CTD_human;ORPHANET
PAX6	Deletion 11p13	C23	Disease or Syndrome	ORPHANET
PAX6	Morning glory anomaly		Disease or Syndrome	UNIPROT
PAX6	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human;GENOMICS_ENGLAND
PAX6	Axenfeld-Rieger Syndrome, Type 1	C11;C16	Disease or Syndrome	CTD_human
PAX6	CATARACTS, CONGENITAL, WITH LATE-ONSET CORNEAL DYSTROPHY		Congenital Abnormality	UNIPROT
PAX6	FOVEAL HYPOPLASIA 1		Disease or Syndrome	UNIPROT
PAX6	ANTERIOR SEGMENT DYSGENESIS 5		Disease or Syndrome	UNIPROT

Pathway associated with PAX6

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001834	Regulation of gene expression in beta cells	reactome	17	54
pathway0002181	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	reactome	20	41
pathway0002182	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	reactome	13	22
pathway0002631	Maturity onset diabetes of the young	kegg	25	76
pathway0002841	Hs_Ectoderm_Differentiation_WP2858_89329	wikipathways	56	137

Go term information of PAX6

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GO_term_name	GO_term_type	TF_name
GO_SPINAL_CORD_DEVELOPMENT	BP	PAX6
GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION	BP	PAX6
GO_AXIS_SPECIFICATION	BP	PAX6
GO_EPITHELIAL_CELL_DEVELOPMENT	BP	PAX6
GO_SALIVARY_GLAND_DEVELOPMENT	BP	PAX6
GO_SPINDLE_LOCALIZATION	BP	PAX6
GO_PITUITARY_GLAND_DEVELOPMENT	BP	PAX6
GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION	BP	PAX6
GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION	BP	PAX6
GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION	BP	PAX6
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD	BP	PAX6
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION	BP	PAX6
GO_FOREBRAIN_REGIONALIZATION	BP	PAX6
GO_FOREBRAIN_GENERATION_OF_NEURONS	BP	PAX6
GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION	BP	PAX6
GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION	BP	PAX6
GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT	BP	PAX6
GO_EPIDERMAL_CELL_DIFFERENTIATION	BP	PAX6
GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	PAX6
GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION	BP	PAX6
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	PAX6
GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING	BP	PAX6
GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION	BP	PAX6
GO_ENDOCRINE_PANCREAS_DEVELOPMENT	BP	PAX6
GO_NEURON_FATE_SPECIFICATION	BP	PAX6
GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	PAX6
GO_EXOCRINE_SYSTEM_DEVELOPMENT	BP	PAX6
GO_PHOTORECEPTOR_CELL_DEVELOPMENT	BP	PAX6
GO_SPINAL_CORD_PATTERNING	BP	PAX6
GO_ASTROCYTE_DIFFERENTIATION	BP	PAX6
GO_REGULATION_OF_NEUROBLAST_PROLIFERATION	BP	PAX6
GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION	BP	PAX6
GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	PAX6
GO_EMBRYONIC_MORPHOGENESIS	BP	PAX6
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT	BP	PAX6
GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION	BP	PAX6
GO_CELL_FATE_DETERMINATION	BP	PAX6
GO_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	PAX6
GO_DIENCEPHALON_DEVELOPMENT	BP	PAX6
GO_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	PAX6
GO_GLIAL_CELL_FATE_COMMITMENT	BP	PAX6
GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC	BP	PAX6
GO_EMBRYONIC_EYE_MORPHOGENESIS	BP	PAX6
GO_ENDOCRINE_SYSTEM_DEVELOPMENT	BP	PAX6
GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	PAX6
GO_TELENCEPHALON_REGIONALIZATION	BP	PAX6
GO_DORSAL_VENTRAL_AXIS_SPECIFICATION	BP	PAX6
GO_FOREBRAIN_NEURON_FATE_COMMITMENT	BP	PAX6
GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT	BP	PAX6
GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT	BP	PAX6
GO_OLIGODENDROCYTE_DIFFERENTIATION	BP	PAX6
GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION	BP	PAX6
GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	PAX6
GO_SKIN_DEVELOPMENT	BP	PAX6
GO_ORGANELLE_LOCALIZATION	BP	PAX6
GO_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	PAX6
GO_CIRCULATORY_SYSTEM_DEVELOPMENT	BP	PAX6
GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT	BP	PAX6
GO_NEURAL_TUBE_PATTERNING	BP	PAX6
GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION	BP	PAX6
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION	BP	PAX6
GO_EYE_MORPHOGENESIS	BP	PAX6
GO_R_SMAD_BINDING	MF	PAX6
GO_CO_SMAD_BINDING	MF	PAX6
GO_HMG_BOX_DOMAIN_BINDING	MF	PAX6
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	PAX6
GO_HISTONE_ACETYLTRANSFERASE_BINDING	MF	PAX6

Survival analysis of PAX6

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of PAX6

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)