Cancer CRCdb

TF information

TF name:	ONECUT1
TF family:	CUT
Ensembl gene ID:	ENSG00000169856
Ensembl protein ID:	ENSP00000476168, ENSP00000302630
Entrez gene ID:	3175

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ONECUT1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_285	Cell line	Liver	HuH7_untreat	0.33797909407666

ONECUT1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_285	Liver	Cell line	HuH7_untreat

ONECUT1 distribution in all CRCs

Genomic distribution of SEs associated with ONECUT1

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Mutation of ONECUT1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ONECUT1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr15	53081458	53081458	G	A	exonic	ONECUT1	synonymous	SKCM\|1\|368\|0.00272
-	chr15	53050013	53050013	C	A	exonic	ONECUT1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	53081129	53081129	C	A	exonic	ONECUT1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	53081884	53081884	T	G	exonic	ONECUT1	synonymous	LIHC\|1\|373\|0.00268
-	chr15	53081026	53081026	C	A	exonic	ONECUT1	nonsynonymous	PRAD\|1\|499\|0.00200
rs779127054	chr15	53081784	53081784	G	A	exonic	ONECUT1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	53081031	53081031	A	G	exonic	ONECUT1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	53081592	53081592	G	T	exonic	ONECUT1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr15	53080980	53080980	C	G	exonic	ONECUT1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	53081051	53081051	C	T	exonic	ONECUT1	nonsynonymous	BRCA\|1\|982\|0.00102,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	53081347	53081347	G	A	exonic	ONECUT1	synonymous	UCEC\|1\|248\|0.00403
rs776607333	chr15	53049880	53049880	A	T	exonic	ONECUT1	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr15	53049965	53049965	G	A	exonic	ONECUT1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	53081560	53081560	G	A	exonic	ONECUT1	synonymous	SKCM\|1\|368\|0.00272
-	chr15	53081565	53081565	C	A	exonic	ONECUT1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr15	53081638	53081638	G	T	exonic	ONECUT1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr15	53081625	53081625	G	A	exonic	ONECUT1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr15	53081670	53081670	G	A	exonic	ONECUT1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	53049780	53049780	G	T	exonic	ONECUT1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	53049925	53049925	G	T	exonic	ONECUT1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr15	53081057	53081057	G	A	exonic	ONECUT1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	53080999	53080999	G	A	exonic	ONECUT1	synonymous	PRAD\|1\|499\|0.00200
rs766649325	chr15	53081958	53081958	C	T	exonic	ONECUT1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs200829865	chr15	53049960	53049960	C	T	exonic	ONECUT1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	53081678	53081678	G	A	exonic	ONECUT1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	53081647	53081647	C	T	exonic	ONECUT1	synonymous	PAAD\|1\|185\|0.00541
-	chr15	53081466	53081466	-	G	exonic	ONECUT1	frameshift	THCA\|1\|504\|0.00198
-	chr15	53081692	53081692	A	C	exonic	ONECUT1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr15	53050034	53050034	C	T	exonic	ONECUT1	synonymous	HNSC\|2\|512\|0.00391
-	chr15	53081808	53081808	C	T	exonic	ONECUT1	nonsynonymous	HNSC\|1\|512\|0.00195
rs746910544	chr15	53049957	53049957	C	T	exonic	ONECUT1	nonsynonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	53081039	53081039	C	T	exonic	ONECUT1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	53081731	53081731	T	G	exonic	ONECUT1	synonymous	HNSC\|1\|512\|0.00195
-	chr15	53081406	53081406	G	A	exonic	ONECUT1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	53081166	53081166	T	C	exonic	ONECUT1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	53082011	53082011	G	-	exonic	ONECUT1	frameshift	TGCT\|1\|155\|0.00645
-	chr15	53081358	53081358	C	A	exonic	ONECUT1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	53049694	53049694	T	A	UTR3	ONECUT1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs780170577	chr15	53049845	53049845	G	A	exonic	ONECUT1	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr15	53081103	53081103	G	T	exonic	ONECUT1	nonsynonymous	LUAD\|1\|543\|0.00184
rs539201961	chr15	53081137	53081137	G	A	exonic	ONECUT1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	53081360	53081360	A	G	exonic	ONECUT1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	53081839	53081839	G	A	exonic	ONECUT1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	53081526	53081526	C	T	exonic	ONECUT1	nonsynonymous	PRAD\|1\|499\|0.00200
rs767975108	chr15	53049924	53049924	C	T	exonic	ONECUT1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	53081468	53081468	-	C	exonic	ONECUT1	frameshift	BRCA\|1\|982\|0.00102
-	chr15	53081680	53081693	GTGGTGGTGGTGAT	-	exonic	ONECUT1	frameshift	SARC\|1\|247\|0.00405
-	chr15	53081346	53081346	C	A	exonic	ONECUT1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr15	53080992	53080992	C	A	exonic	ONECUT1	nonsynonymous	LUSC\|1\|178\|0.00562
rs767594063	chr15	53081276	53081276	C	T	exonic	ONECUT1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	53081428	53081428	G	A	exonic	ONECUT1	synonymous	UCEC\|1\|248\|0.00403
-	chr15	53081866	53081867	GT	-	exonic	ONECUT1	frameshift	THYM\|1\|123\|0.00813
-	chr15	53081028	53081028	T	C	exonic	ONECUT1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr15	53081749	53081749	C	T	exonic	ONECUT1	synonymous	ESCA\|1\|185\|0.00541
-	chr15	53081701	53081701	G	A	exonic	ONECUT1	synonymous	LUAD\|1\|543\|0.00184
-	chr15	53081196	53081196	C	G	exonic	ONECUT1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	53081206	53081206	G	C	exonic	ONECUT1	nonsynonymous	BLCA\|1\|396\|0.00253
rs564638027	chr15	53081290	53081290	G	A	exonic	ONECUT1	synonymous	SKCM\|1\|368\|0.00272
-	chr15	53081966	53081966	G	C	exonic	ONECUT1	nonsynonymous	HNSC\|1\|512\|0.00195
rs550465203	chr15	53081412	53081412	C	T	exonic	ONECUT1	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr15	53081863	53081863	C	T	exonic	ONECUT1	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr15	53081569	53081569	G	A	exonic	ONECUT1	synonymous	PRAD\|1\|499\|0.00200
-	chr15	53081207	53081207	A	G	exonic	ONECUT1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs766909306	chr15	53081070	53081070	T	C	exonic	ONECUT1	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr15	53081088	53081088	G	A	exonic	ONECUT1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs748598047	chr15	53081035	53081035	C	T	exonic	ONECUT1	synonymous	SKCM\|1\|368\|0.00272
-	chr15	53049804	53049804	C	T	exonic	ONECUT1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	53081808	53081808	C	A	exonic	ONECUT1	stopgain	BLCA\|1\|396\|0.00253
-	chr15	53081523	53081523	G	A	exonic	ONECUT1	synonymous	LUSC\|1\|178\|0.00562
-	chr15	53081052	53081052	G	A	exonic	ONECUT1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	53082076	53082076	G	A	exonic	ONECUT1	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr15	53081197	53081197	T	G	exonic	ONECUT1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	53081585	53081585	G	A	exonic	ONECUT1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of ONECUT1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with ONECUT1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000826	FOXM1 transcription factor network	pid	43	294
pathway0001835	Regulation of gene expression in early pancreatic precursor cells	reactome	8	8
pathway0001837	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	reactome	7	9
pathway0002631	Maturity onset diabetes of the young	kegg	25	76
pathway0002740	Hs_Endoderm_Differentiation_WP2853_88152	wikipathways	62	260

Go term information of ONECUT1

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GO_term_name	GO_term_type	TF_name
GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT	BP	ONECUT1
GO_POSITIVE_REGULATION_OF_LOCOMOTION	BP	ONECUT1
GO_PANCREAS_DEVELOPMENT	BP	ONECUT1
GO_B_CELL_DIFFERENTIATION	BP	ONECUT1
GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS	BP	ONECUT1
GO_ENDOCRINE_PANCREAS_DEVELOPMENT	BP	ONECUT1
GO_CILIUM_ORGANIZATION	BP	ONECUT1
GO_ENDODERM_DEVELOPMENT	BP	ONECUT1
GO_GLUCOSE_METABOLIC_PROCESS	BP	ONECUT1
GO_MONOSACCHARIDE_METABOLIC_PROCESS	BP	ONECUT1
GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY	BP	ONECUT1
GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION	BP	ONECUT1
GO_SPLEEN_DEVELOPMENT	BP	ONECUT1
GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	ONECUT1

Survival analysis of ONECUT1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ONECUT1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)