Cancer CRCdb

TF information

TF name:	NR1H4
TF family:	THR-like
Ensembl gene ID:	ENSG00000012504
Ensembl protein ID:	ENSP00000315442, ENSP00000447149, ENSP00000448978, ENSP00000448506, ENSP00000376712, ENSP00000188403
Entrez gene ID:	9971

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NR1H4 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_285	Cell line	Liver	HuH7_untreat	0.062717770034843

NR1H4 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

NR1H4 distribution in all CRCs

Genomic distribution of SEs associated with NR1H4

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Mutation of NR1H4

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NR1H4

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs748378207	chr12	100930769	100930769	C	T	exonic	NR1H4	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	100934551	100934551	C	-	exonic	NR1H4	frameshift	HNSC\|1\|512\|0.00195
rs113431969	chr12	100904745	100904745	G	A	exonic	NR1H4	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100934521	100934521	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272,UCS\|1\|57\|0.01754
-	chr12	100904667	100904667	C	T	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	100904692	100904692	C	T	exonic	NR1H4	synonymous	PCPG\|1\|184\|0.00543
rs767379406	chr12	100904824	100904824	G	A	exonic	NR1H4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|1\|512\|0.00195,STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr12	100897181	100897181	C	T	exonic	NR1H4	stopgain	LUSC\|1\|178\|0.00562
-	chr12	100957089	100957089	T	C	exonic	NR1H4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100904705	100904705	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100926320	100926320	G	T	exonic	NR1H4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100897255	100897255	G	T	exonic	NR1H4	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs778260507	chr12	100928723	100928723	G	A	exonic	NR1H4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs778715261	chr12	100957258	100957258	C	T	exonic	NR1H4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100957204	100957204	G	A	exonic	NR1H4	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	100930752	100930752	A	T	exonic	NR1H4	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	100928694	100928694	T	C	exonic	NR1H4	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	100926300	100926300	G	A	exonic	NR1H4	synonymous	LUAD\|1\|543\|0.00184
rs766734563	chr12	100897268	100897268	G	A	exonic	NR1H4	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	100904813	100904813	C	A	exonic	NR1H4	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	100897237	100897237	-	T	exonic	NR1H4	frameshift	ESCA\|1\|185\|0.00541
-	chr12	100926345	100926345	G	A	exonic	NR1H4	synonymous	SKCM\|1\|368\|0.00272
-	chr12	100930822	100930822	C	A	exonic	NR1H4	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	100955769	100955769	G	A	exonic	NR1H4	synonymous	UCEC\|1\|248\|0.00403
-	chr12	100897224	100897224	G	T	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
rs747025458	chr12	100897230	100897230	C	T	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
rs769086612	chr12	100904813	100904813	C	T	exonic	NR1H4	nonsynonymous	CESC\|1\|194\|0.00515
-	chr12	100930764	100930764	T	G	exonic	NR1H4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	100930826	100930826	G	A	splicing	NR1H4	splicing	OV\|1\|469\|0.00213
-	chr12	100930750	100930750	G	C	exonic	NR1H4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	100957082	100957082	C	T	exonic	NR1H4	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr12	100934501	100934501	C	G	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
rs200231287	chr12	100926265	100926265	G	T	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	100957220	100957220	G	T	exonic	NR1H4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100930806	100930806	A	C	exonic	NR1H4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100934464	100934464	G	A	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100904639	100904639	C	A	exonic	NR1H4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100934522	100934522	G	A	exonic	NR1H4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	100930756	100930756	T	G	exonic	NR1H4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	100930351	100930351	A	G	exonic	NR1H4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100957037	100957037	T	C	exonic	NR1H4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	100930343	100930343	T	G	exonic	NR1H4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs375599105	chr12	100904822	100904822	G	A	exonic	NR1H4	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	100904904	100904904	C	T	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	100928670	100928670	T	G	exonic	NR1H4	nonsynonymous	UCS\|1\|57\|0.01754
-	chr12	100904587	100904587	G	-	exonic	NR1H4	frameshift	LUSC\|1\|178\|0.00562
rs148156024	chr12	100904617	100904617	G	A	exonic	NR1H4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100955661	100955661	A	T	splicing	NR1H4	splicing	HNSC\|1\|512\|0.00195
-	chr12	100904848	100904848	T	A	exonic	NR1H4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	100904596	100904596	C	T	exonic	NR1H4	synonymous	BRCA\|1\|982\|0.00102
-	chr12	100928726	100928726	T	C	exonic	NR1H4	synonymous	LUAD\|1\|543\|0.00184
-	chr12	100955731	100955731	C	A	exonic	NR1H4	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	100930297	100930297	C	G	exonic	NR1H4	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs764421287	chr12	100928794	100928794	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
rs768563784	chr12	100928738	100928738	C	A	exonic	NR1H4	synonymous	LUAD\|1\|543\|0.00184
-	chr12	100887103	100887103	T	A	exonic	NR1H4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100934550	100934550	T	G	exonic	NR1H4	synonymous	SARC\|1\|247\|0.00405
rs762904675	chr12	100934588	100934588	G	A	exonic	NR1H4	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,SKCM\|1\|368\|0.00272
rs113090017	chr12	100926316	100926316	C	T	exonic	NR1H4	stopgain	SARC\|1\|247\|0.00405
-	chr12	100928730	100928730	G	C	exonic	NR1H4	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	100926383	100926383	A	C	exonic	NR1H4	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	100955671	100955671	G	A	exonic	NR1H4	nonsynonymous	BRCA\|1\|982\|0.00102
rs770333055	chr12	100926248	100926248	G	T	exonic	NR1H4	nonsynonymous	UCEC\|1\|248\|0.00403
rs760756841	chr12	100957179	100957179	A	G	exonic	NR1H4	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	100926248	100926248	G	C	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	100904639	100904639	C	-	exonic	NR1H4	frameshift	LIHC\|1\|373\|0.00268
-	chr12	100955674	100955674	G	T	exonic	NR1H4	stopgain	HNSC\|1\|512\|0.00195
-	chr12	100930770	100930770	G	A	exonic	NR1H4	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	100934531	100934539	AGATTTTCA	-	exonic	NR1H4	nonframeshift	LIHC\|1\|373\|0.00268
-	chr12	100904796	100904796	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100928777	100928777	G	C	exonic	NR1H4	synonymous	BRCA\|2\|982\|0.00204
-	chr12	100904593	100904593	G	C	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
rs764990636	chr12	100934575	100934575	G	A	exonic	NR1H4	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	100928734	100928734	A	T	exonic	NR1H4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	100897197	100897197	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100928738	100928738	C	G	exonic	NR1H4	synonymous	LUSC\|1\|178\|0.00562
-	chr12	100904721	100904721	C	G	exonic	NR1H4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	100926237	100926237	T	C	exonic	NR1H4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100897200	100897200	T	A	exonic	NR1H4	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	100926373	100926373	G	A	exonic	NR1H4	nonsynonymous	LUAD\|3\|543\|0.00552
-	chr12	100930827	100930827	T	C	splicing	NR1H4	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100934589	100934589	A	G	exonic	NR1H4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100904774	100904774	G	A	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100928704	100928704	T	C	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272
-	chr12	100957235	100957235	C	A	exonic	NR1H4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	100904867	100904867	G	T	exonic	NR1H4	stopgain	UCEC\|1\|248\|0.00403
-	chr12	100934528	100934528	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100897248	100897248	A	T	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	100926360	100926360	G	A	exonic	NR1H4	nonsynonymous	LUAD\|3\|543\|0.00552
-	chr12	100904849	100904852	GAGC	-	exonic	NR1H4	frameshift	SKCM\|2\|368\|0.00543
-	chr12	100934574	100934574	G	A	exonic	NR1H4	synonymous	LUAD\|4\|543\|0.00737
rs750165978	chr12	100904735	100904735	G	A	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100897247	100897247	G	A	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100897210	100897210	T	C	exonic	NR1H4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100904815	100904815	C	A	exonic	NR1H4	synonymous	LUAD\|1\|543\|0.00184
-	chr12	100904719	100904719	C	A	exonic	NR1H4	stopgain	BLCA\|1\|396\|0.00253
-	chr12	100926293	100926293	A	G	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100904639	100904639	C	T	exonic	NR1H4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	100897258	100897258	T	A	exonic	NR1H4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	100926317	100926317	G	A	exonic	NR1H4	nonsynonymous	SKCM\|2\|368\|0.00543
rs750222671	chr12	100934587	100934587	C	A	exonic	NR1H4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100928758	100928758	G	A	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100928738	100928738	C	T	exonic	NR1H4	synonymous	SKCM\|1\|368\|0.00272
-	chr12	100955744	100955744	C	T	exonic	NR1H4	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	100928737	100928737	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100926249	100926249	A	T	exonic	NR1H4	nonsynonymous	LUAD\|1\|543\|0.00184
rs748525265	chr12	100897267	100897267	C	A	exonic	NR1H4	synonymous	LUAD\|1\|543\|0.00184
-	chr12	100957095	100957095	A	-	exonic	NR1H4	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100887129	100887129	C	A	exonic	NR1H4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	100957082	100957082	C	A	exonic	NR1H4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	100955761	100955761	G	T	exonic	NR1H4	nonsynonymous	ESCA\|1\|185\|0.00541
rs868079755	chr12	100904661	100904661	C	T	exonic	NR1H4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	100887150	100887150	G	T	exonic	NR1H4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	100957256	100957256	G	A	exonic	NR1H4	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	100904733	100904733	A	T	exonic	NR1H4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	100934587	100934587	C	T	exonic	NR1H4	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	100904815	100904815	C	T	exonic	NR1H4	synonymous	LUAD\|1\|543\|0.00184

Disease information of NR1H4

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NR1H4	Cholestasis	C06	Disease or Syndrome	CTD_human;GENOMICS_ENGLAND
NR1H4	Crohn Disease	C06	Disease or Syndrome	CTD_human
NR1H4	Extravasation of Contrast Media	C23;C26	Pathologic Function	CTD_human
NR1H4	Extravasation of Diagnostic and Therapeutic Materials	C23;C26	Injury or Poisoning	CTD_human
NR1H4	Fatty Liver	C06	Disease or Syndrome	CTD_human
NR1H4	Hepatitis, Toxic	C06;C25	Injury or Poisoning	CTD_human
NR1H4	Hepatomegaly	C06;C23	Finding	CTD_human
NR1H4	Inflammation	C23	Pathologic Function	CTD_human
NR1H4	Intestinal Neoplasms	C04;C06	Neoplastic Process	CTD_human
NR1H4	Liver diseases	C06	Disease or Syndrome	CTD_human
NR1H4	Liver neoplasms	C04;C06	Neoplastic Process	CTD_human
NR1H4	Liver Dysfunction	C06	Finding	CTD_human
NR1H4	Crohn's disease of large bowel	C06	Disease or Syndrome	CTD_human
NR1H4	Crohn's disease of the ileum	C06	Disease or Syndrome	CTD_human
NR1H4	Cholestasis of pregnancy	C06;C13	Disease or Syndrome	ORPHANET
NR1H4	Malignant neoplasm of liver	C04;C06	Neoplastic Process	CTD_human
NR1H4	Intestinal Cancer	C04;C06	Neoplastic Process	CTD_human
NR1H4	Non-alcoholic Fatty Liver Disease	C06	Disease or Syndrome	CTD_human
NR1H4	Regional enteritis	C06	Disease or Syndrome	CTD_human
NR1H4	Drug-Induced Liver Disease	C06;C25	Disease or Syndrome	CTD_human
NR1H4	IIeocolitis	C06	Disease or Syndrome	CTD_human
NR1H4	Cholestasis in newborn		Disease or Syndrome	GENOMICS_ENGLAND
NR1H4	Hepatitis, Drug-Induced	C06;C25	Disease or Syndrome	CTD_human
NR1H4	Liver carcinoma	C04;C06	Neoplastic Process	CTD_human
NR1H4	Steatohepatitis	C06	Disease or Syndrome	CTD_human
NR1H4	Nonalcoholic Steatohepatitis	C06	Disease or Syndrome	CTD_human
NR1H4	Familial intrahepatic cholestasis of pregnancy	C06;C13	Disease or Syndrome	ORPHANET
NR1H4	Drug-Induced Acute Liver Injury	C06;C25	Disease or Syndrome	CTD_human
NR1H4	Chemical and Drug Induced Liver Injury	C06;C25	Disease or Syndrome	CTD_human
NR1H4	Chemically-Induced Liver Toxicity	C06;C25	Disease or Syndrome	CTD_human
NR1H4	CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 5		Disease or Syndrome	CTD_human;ORPHANET

Pathway associated with NR1H4

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000664	Endogenous sterols	reactome	22	41
pathway0001534	Nuclear Receptor transcription pathway	reactome	51	284
pathway0001815	Recycling of bile acids and salts	reactome	15	37
pathway0001947	RXR and RAR heterodimerization with other nuclear receptor	pid	26	164
pathway0002153	Synthesis of bile acids and bile salts	reactome	7	17
pathway0002155	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	reactome	15	38
pathway0002156	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	reactome	24	87
pathway0002685	Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593	wikipathways	9	12

Go term information of NR1H4

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GO_term_name	GO_term_type	TF_name
GO_ACYLGLYCEROL_HOMEOSTASIS	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION	BP	NR1H4
GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION	BP	NR1H4
GO_CELLULAR_RESPONSE_TO_LIPID	BP	NR1H4
GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS	BP	NR1H4
GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS	BP	NR1H4
GO_HISTONE_METHYLATION	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS	BP	NR1H4
GO_REGULATION_OF_HORMONE_LEVELS	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS	BP	NR1H4
GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE	BP	NR1H4
GO_PEPTIDYL_ARGININE_MODIFICATION	BP	NR1H4
GO_REGULATION_OF_LIPID_METABOLIC_PROCESS	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION	BP	NR1H4
GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS	BP	NR1H4
GO_COVALENT_CHROMATIN_MODIFICATION	BP	NR1H4
GO_NOTCH_SIGNALING_PATHWAY	BP	NR1H4
GO_BILE_ACID_AND_BILE_SALT_TRANSPORT	BP	NR1H4
GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY	BP	NR1H4
GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	NR1H4
GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION	BP	NR1H4
GO_CELLULAR_RESPONSE_TO_NUTRIENT	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING	BP	NR1H4
GO_CYTOKINE_SECRETION	BP	NR1H4
GO_CELLULAR_RESPONSE_TO_FATTY_ACID	BP	NR1H4
GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY	BP	NR1H4
GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS	BP	NR1H4
GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS	BP	NR1H4
GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION	BP	NR1H4
GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE	BP	NR1H4
GO_PEPTIDYL_ARGININE_METHYLATION	BP	NR1H4
GO_BILE_ACID_METABOLIC_PROCESS	BP	NR1H4
GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION	BP	NR1H4
GO_NUCLEAR_EUCHROMATIN	CC	NR1H4
GO_EUCHROMATIN	CC	NR1H4
GO_ENHANCER_BINDING	MF	NR1H4
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	NR1H4
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY	MF	NR1H4
GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING	MF	NR1H4
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	NR1H4
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	NR1H4
GO_RETINOIC_ACID_RECEPTOR_BINDING	MF	NR1H4
GO_RETINOID_X_RECEPTOR_BINDING	MF	NR1H4
GO_MONOCARBOXYLIC_ACID_BINDING	MF	NR1H4

Survival analysis of NR1H4

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NR1H4

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)