TF information

TF name: NFYC
TF family: NF-YC
Ensembl gene ID: ENSG00000066136
Ensembl protein ID: ENSP00000436710, ENSP00000361738, ENSP00000361734, ENSP00000409219, ENSP00000396620, ENSP00000361737, ENSP00000416403, ENSP00000408867, ENSP00000408315, ENSP00000312617, ENSP00000433820, ENSP00000397647, ENSP00000433413, ENSP00000414299, ENSP00000434404, ENSP00000361736
Entrez gene ID: 4802
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of NFYC in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_179Cell lineUrinary bladderT240.057471264367816
Sample_02_317Cell lineNeuroblastomaGICAN0.027027027027027

NFYC distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

NFYC distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with NFYC
Download

Mutation of NFYC
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NFYC

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr14122859041228590GAexonicNFYCnonsynonymous SKCM|1|368|0.00272
-chr14123232041232320CGexonicNFYCstopgain LUAD|1|543|0.00184
-chr14123633741236337CTintronicNFYCunknown BRCA|1|982|0.00102,SKCM|1|368|0.00272
rs200544060chr14123647141236471GAexonicNFYCnonsynonymous CESC|1|194|0.00515
-chr14120460641204606CGexonicNFYCnonsynonymous SKCM|1|368|0.00272
-chr14122392241223922AGexonicNFYCnonsynonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr14123502641235026ATsplicingNFYCsplicing UCEC|1|248|0.00403
-chr14121890641218906TGexonicNFYCsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr14121326941213269GAexonicNFYCnonsynonymous BRCA|2|982|0.00204
-chr14122863941228639AGexonicNFYCnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr14117636241176370TCGAGGGTG-intronicNFYCunknown -
-chr14121321441213214CTexonicNFYCsynonymous LUAD|1|543|0.00184
-chr14122871341228713ATexonicNFYCnonsynonymous HNSC|1|512|0.00195
-chr14122863241228632GTexonicNFYCnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr14122859041228590GCexonicNFYCnonsynonymous LUAD|1|543|0.00184
-chr14121534841215348GAexonicNFYCnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr14123648041236480CTexonicNFYCnonsynonymous LUAD|2|543|0.00368
-chr14120452341204523CTexonicNFYCnonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr14123505041235050AGexonicNFYCnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs756903355chr14122864641228646GAexonicNFYCsynonymous BRCA|1|982|0.00102
-chr14121531541215315GCexonicNFYCnonsynonymous LIHC|1|373|0.00268
-chr14121887741218877GAexonicNFYCnonsynonymous PRAD|1|499|0.00200
-chr14122871241228712GCexonicNFYCnonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr14120455941204559C-exonicNFYCframeshift LIHC|1|373|0.00268
rs139077351chr14122386541223865GAexonicNFYCnonsynonymous PRAD|1|499|0.00200
-chr14123647741236477-CexonicNFYCframeshift KIPAN|1|799|0.00125,KIRC|1|451|0.00222,LUAD|1|543|0.00184
-chr14121325041213250GAexonicNFYCsynonymous HNSC|2|512|0.00391
-chr14123236341232363CTexonicNFYCsynonymous LUAD|1|543|0.00184
-chr14123649941236499GAexonicNFYCsynonymous BLCA|1|396|0.00253,BRCA|1|982|0.00102,ESCA|2|185|0.01081
rs779107990chr14121531441215314CTexonicNFYCstopgain BLCA|1|396|0.00253
-chr14121326741213267ATexonicNFYCnonsynonymous LUAD|1|543|0.00184
rs866880681chr14120458541204585CAexonicNFYCnonsynonymous KIPAN|2|799|0.00250,KIRC|2|451|0.00443
-chr14122392341223923TCexonicNFYCnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr14122393141223931GTexonicNFYCnonsynonymous OV|1|469|0.00213
-chr14122382541223825GTexonicNFYCnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr14123649841236498TAexonicNFYCstoploss UCEC|1|248|0.00403
rs139444755chr14121887641218876CTexonicNFYCsynonymous BLCA|1|396|0.00253
-chr14121882441218824GTexonicNFYCnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,ESCA|1|185|0.00541
rs750033303chr14123618141236181-CintronicNFYCunknown BRCA|1|982|0.00102
-chr14123502741235027GAsplicingNFYCsplicing HNSC|1|512|0.00195
-chr14121321641213216GAexonicNFYCnonsynonymous DLBC|1|48|0.02083
-chr14120455041204550GAexonicNFYCnonsynonymous PRAD|2|499|0.00401
-chr14122389841223898CTexonicNFYCstopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs768809484chr14123642941236429GAexonicNFYCnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr14121534641215346CTexonicNFYCsynonymous LUAD|2|543|0.00368
rs747532331chr14122394641223946GAexonicNFYCnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr14121888041218880AGexonicNFYCnonsynonymous UCEC|1|248|0.00403
-chr14121884641218846TCexonicNFYCsynonymous UCEC|1|248|0.00403
-chr14122391441223914CTexonicNFYCnonsynonymous PAAD|1|185|0.00541
-chr14123258841232588AGsplicingNFYCsplicing DLBC|1|48|0.02083
-chr14122379841223798GCexonicNFYCnonsynonymous LUAD|1|543|0.00184

Disease information of NFYC
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
NFYC Malignant neoplasm of breast C04;C17 Neoplastic Process UNIPROT

Pathway associated with NFYC
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000069 Activation of gene expression by SREBF (SREBP) reactome 42 266
pathway0000230 ATF4 activates genes reactome 25 112
pathway0000231 ATF6-alpha activates chaperone genes reactome 10 27
pathway0002391 Validated targets of C-MYC transcriptional repression pid 63 385
pathway0002601 Antigen processing and presentation kegg 75 466

Go term information of NFYC
GO_term_name GO_term_type TF_name
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX CC NFYC
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING MF NFYC
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING MF NFYC

Survival analysis of NFYC



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of NFYC