1. TF detail

TF information

TF name: HES5
TF family: bHLH
Ensembl gene ID: ENSG00000197921
Ensembl protein ID: ENSP00000367714
Entrez gene ID: 388585
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:
Frequency of HES5 in all biosamples
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Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_021Cell lineColonV4290.1464398962237
HES5 distribution in samples’ most representative CRC
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Sample ID Tissue type Biosample type Biosample name
HES5 distribution in all CRCs
Biosample type
Biosample name
Sample ID
Genomic distribution of SEs associated with HES5
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Mutation of HES5
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Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HES5

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr124613822461382CGexonicHES5synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
rs745880943chr124613312461331CTexonicHES5synonymous LUAD|1|543|0.00184
-chr124613522461352CTexonicHES5synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr124612852461285CAexonicHES5nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
Disease information of HES5
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TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
HES5 Brain Neoplasms C04;C10 Neoplastic Process CTD_human
HES5 nervous system disorder C10 Disease or Syndrome CTD_human
HES5 Malignant neoplasm of brain C04;C10 Neoplastic Process CTD_human
HES5 Benign neoplasm of brain, unspecified C04;C10 Neoplastic Process CTD_human
HES5 Brain Tumor, Primary C04;C10 Neoplastic Process CTD_human
HES5 Recurrent Brain Neoplasm C04;C10 Neoplastic Process CTD_human
HES5 Primary malignant neoplasm of brain C04;C10 Neoplastic Process CTD_human
HES5 Neoplasms, Intracranial C04;C10 Neoplastic Process CTD_human
Pathway associated with HES5
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pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000390 CDC42 signaling events pid 71 630
pathway0000483 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57 500
pathway0000484 Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57 500
pathway0001517 Notch netpath 76 661
pathway0001524 NOTCH1 Intracellular Domain Regulates Transcription reactome 47 463
pathway0001526 NOTCH2 intracellular domain regulates transcription reactome 12 53
pathway0002589 Notch signaling pathway kegg 44 313
Go term information of HES5
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GO_term_name GO_term_type TF_name
GO_METANEPHRIC_NEPHRON_MORPHOGENESIS BP HES5
GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN BP HES5
GO_METANEPHROS_DEVELOPMENT BP HES5
GO_CARTILAGE_DEVELOPMENT BP HES5
GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION BP HES5
GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY BP HES5
GO_NEGATIVE_REGULATION_OF_GLIOGENESIS BP HES5
GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT BP HES5
GO_LOOP_OF_HENLE_DEVELOPMENT BP HES5
GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION BP HES5
GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION BP HES5
GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY BP HES5
GO_REGULATION_OF_MYELINATION BP HES5
GO_KIDNEY_EPITHELIUM_DEVELOPMENT BP HES5
GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION BP HES5
GO_FOREBRAIN_DEVELOPMENT BP HES5
GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION BP HES5
GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION BP HES5
GO_FOREBRAIN_GENERATION_OF_NEURONS BP HES5
GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY BP HES5
GO_PROXIMAL_DISTAL_PATTERN_FORMATION BP HES5
GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION BP HES5
GO_NEPHRON_EPITHELIUM_DEVELOPMENT BP HES5
GO_ENSHEATHMENT_OF_NEURONS BP HES5
GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS BP HES5
GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM BP HES5
GO_CHONDROCYTE_DIFFERENTIATION BP HES5
GO_ASTROCYTE_DIFFERENTIATION BP HES5
GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION BP HES5
GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION BP HES5
GO_MAINTENANCE_OF_CELL_NUMBER BP HES5
GO_METANEPHRIC_NEPHRON_DEVELOPMENT BP HES5
GO_EPIDERMIS_DEVELOPMENT BP HES5
GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN BP HES5
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION BP HES5
GO_SEGMENT_SPECIFICATION BP HES5
GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION BP HES5
GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION BP HES5
GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE BP HES5
GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION BP HES5
GO_MECHANORECEPTOR_DIFFERENTIATION BP HES5
GO_TUBE_FORMATION BP HES5
GO_CELL_FATE_DETERMINATION BP HES5
GO_HAIR_CELL_DIFFERENTIATION BP HES5
GO_SMOOTHENED_SIGNALING_PATHWAY BP HES5
GO_REGULATION_OF_BMP_SIGNALING_PATHWAY BP HES5
GO_GLIAL_CELL_FATE_COMMITMENT BP HES5
GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION BP HES5
GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION BP HES5
GO_OLIGODENDROCYTE_DEVELOPMENT BP HES5
GO_NEURON_FATE_COMMITMENT BP HES5
GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN BP HES5
GO_KIDNEY_MORPHOGENESIS BP HES5
GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY BP HES5
GO_OLIGODENDROCYTE_DIFFERENTIATION BP HES5
GO_NEPHRON_TUBULE_FORMATION BP HES5
GO_NEPHRON_DEVELOPMENT BP HES5
GO_TELENCEPHALON_DEVELOPMENT BP HES5
GO_REGULATION_OF_GLIOGENESIS BP HES5
GO_EPITHELIAL_CELL_FATE_COMMITMENT BP HES5
GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT BP HES5
GO_METANEPHROS_MORPHOGENESIS BP HES5
GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION BP HES5
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING MF HES5

Survival analysis of HES5


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of HES5

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)