Cancer CRCdb

TF information

TF name:	GLI1
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000111087
Ensembl protein ID:	ENSP00000436671, ENSP00000441006, ENSP00000437607, ENSP00000434408, ENSP00000228682
Entrez gene ID:	2735

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of GLI1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_164	Cell line	Lung	H2087_Parental	0.63333333333333

GLI1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_164	Lung	Cell line	H2087_Parental

GLI1 distribution in all CRCs

Genomic distribution of SEs associated with GLI1

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Mutation of GLI1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of GLI1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr12	57865427	57865427	A	G	exonic	GLI1	synonymous	UCEC\|1\|248\|0.00403
rs141854128	chr12	57861208	57861208	C	T	exonic	GLI1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57864972	57864972	G	A	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57864141	57864141	G	A	exonic	GLI1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	57865654	57865654	A	G	exonic	GLI1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	57865022	57865022	C	G	exonic	GLI1	synonymous	HNSC\|1\|512\|0.00195
-	chr12	57864972	57864972	G	T	exonic	GLI1	stopgain	ESCA\|1\|185\|0.00541
rs200306754	chr12	57864118	57864118	G	A	exonic	GLI1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	57859576	57859576	C	T	exonic	GLI1	synonymous	BRCA\|1\|982\|0.00102
-	chr12	57865608	57865608	C	T	exonic	GLI1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	57857868	57857868	A	C	exonic	GLI1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	57864851	57864851	C	T	exonic	GLI1	synonymous	ESCA\|1\|185\|0.00541
rs770128594	chr12	57865714	57865714	C	T	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57864698	57864698	A	C	exonic	GLI1	synonymous	BRCA\|1\|982\|0.00102
rs376198615	chr12	57861833	57861833	G	A	exonic	GLI1	synonymous	UCEC\|1\|248\|0.00403
-	chr12	57864991	57864991	G	T	exonic	GLI1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	57861968	57861968	C	G	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	57858524	57858524	C	A	exonic	GLI1	nonsynonymous	LAML\|1\|197\|0.00508
-	chr12	57865064	57865064	C	T	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
rs200909709	chr12	57857795	57857795	G	A	exonic	GLI1	synonymous	BLCA\|1\|396\|0.00253
rs768202810	chr12	57864396	57864396	G	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57864471	57864471	G	T	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
rs764631331	chr12	57861870	57861870	G	A	exonic	GLI1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	57863474	57863474	C	A	exonic	GLI1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57865272	57865272	G	T	exonic	GLI1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	57859603	57859603	G	A	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
-	chr12	57861141	57861141	C	A	exonic	GLI1	stopgain	LUAD\|1\|543\|0.00184
-	chr12	57861946	57861946	G	C	exonic	GLI1	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	57865110	57865110	G	C	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57861143	57861143	C	A	exonic	GLI1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	57861144	57861144	G	T	exonic	GLI1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	57859445	57859445	G	A	exonic	GLI1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr12	57865470	57865470	C	T	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57861986	57861986	G	T	exonic	GLI1	synonymous	BLCA\|1\|396\|0.00253
-	chr12	57859671	57859671	G	A	exonic	GLI1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	57864806	57864806	T	G	exonic	GLI1	stopgain	UCEC\|1\|248\|0.00403
-	chr12	57858609	57858609	C	A	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	57863408	57863408	C	G	exonic	GLI1	synonymous	LUAD\|1\|543\|0.00184
rs774005775	chr12	57861832	57861832	C	T	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
rs760192848	chr12	57858477	57858477	G	A	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
rs759448855	chr12	57860075	57860075	G	-	exonic	GLI1	frameshift	COAD\|5\|367\|0.01362,COADREAD\|7\|489\|0.01431,PAAD\|1\|185\|0.00541,READ\|2\|122\|0.01639,STAD\|8\|395\|0.02025,STES\|8\|395\|0.02025
rs140333004	chr12	57865805	57865805	C	T	exonic	GLI1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs368789621	chr12	57860075	57860075	G	T	exonic	GLI1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	57861915	57861915	G	A	exonic	GLI1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	57858626	57858626	G	T	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
rs761285829	chr12	57861869	57861869	C	T	exonic	GLI1	synonymous	BLCA\|1\|396\|0.00253
-	chr12	57857788	57857788	C	G	exonic	GLI1	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr12	57864506	57864506	C	A	exonic	GLI1	synonymous	PAAD\|1\|185\|0.00541
-	chr12	57864730	57864730	A	T	exonic	GLI1	nonsynonymous	PRAD\|1\|499\|0.00200
rs201621277	chr12	57860054	57860054	G	A	exonic	GLI1	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	57858581	57858581	G	T	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
rs758959112	chr12	57864291	57864291	C	T	exonic	GLI1	nonsynonymous	HNSC\|1\|512\|0.00195
rs751461298	chr12	57858597	57858597	C	T	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57865314	57865314	C	A	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57864593	57864593	C	T	exonic	GLI1	synonymous	LUAD\|1\|543\|0.00184
-	chr12	57865760	57865760	-	C	exonic	GLI1	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	57861838	57861838	G	A	exonic	GLI1	nonsynonymous	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613,UCEC\|1\|248\|0.00403
-	chr12	57865069	57865069	C	T	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
rs766134206	chr12	57858641	57858641	G	A	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
rs267603606	chr12	57865804	57865804	C	T	exonic	GLI1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	57863445	57863445	A	G	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57859444	57859444	G	A	exonic	GLI1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr12	57864218	57864218	C	-	exonic	GLI1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57864435	57864435	A	G	exonic	GLI1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	57864776	57864776	G	T	exonic	GLI1	synonymous	LUSC\|1\|178\|0.00562
-	chr12	57857801	57857801	C	A	exonic	GLI1	nonsynonymous	BRCA\|1\|982\|0.00102
rs760909851	chr12	57865236	57865236	C	G	exonic	GLI1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	57864117	57864117	C	A	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57865691	57865691	C	A	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
-	chr12	57858606	57858606	C	T	exonic	GLI1	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	57865380	57865380	G	T	exonic	GLI1	stopgain	UCEC\|1\|248\|0.00403
rs376293205	chr12	57861892	57861892	G	A	exonic	GLI1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	57861814	57861814	G	A	exonic	GLI1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	57864973	57864973	A	G	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57864419	57864419	T	A	exonic	GLI1	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	57857532	57857532	C	A	exonic	GLI1	synonymous	LUAD\|1\|543\|0.00184
-	chr12	57859574	57859574	C	T	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|2\|368\|0.00543
-	chr12	57863329	57863329	C	G	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	57859040	57859040	T	C	splicing	GLI1	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57857824	57857824	C	T	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57864343	57864343	C	T	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57865615	57865615	G	A	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57864569	57864569	C	A	exonic	GLI1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57858976	57858976	G	T	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57863310	57863310	G	T	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57864774	57864774	C	G	exonic	GLI1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr12	57865037	57865037	T	G	exonic	GLI1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	57865728	57865728	G	A	exonic	GLI1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	57858949	57858949	T	A	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57865459	57865459	A	G	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	57860099	57860099	G	T	exonic	GLI1	nonsynonymous	PAAD\|1\|185\|0.00541
rs768421030	chr12	57865076	57865076	C	A	exonic	GLI1	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	57858619	57858619	C	T	exonic	GLI1	synonymous	HNSC\|1\|512\|0.00195
-	chr12	57857530	57857530	T	C	exonic	GLI1	nonsynonymous	LIHC\|1\|373\|0.00268
rs200097138	chr12	57859625	57859625	C	T	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57857855	57857855	G	A	exonic	GLI1	synonymous	HNSC\|1\|512\|0.00195
-	chr12	57865330	57865330	T	C	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57864713	57864713	G	A	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
-	chr12	57859465	57859465	T	C	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57863263	57863263	C	T	exonic	GLI1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs775573332	chr12	57864329	57864329	G	A	exonic	GLI1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57864284	57864284	C	A	exonic	GLI1	stopgain	SARC\|1\|247\|0.00405
-	chr12	57861986	57861986	G	A	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
-	chr12	57857781	57857781	G	A	splicing	GLI1	splicing	SKCM\|1\|368\|0.00272
-	chr12	57865355	57865355	A	C	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
-	chr12	57858936	57858936	G	T	exonic	GLI1	synonymous	ESCA\|1\|185\|0.00541
-	chr12	57857822	57857822	G	A	exonic	GLI1	nonsynonymous	LUSC\|1\|178\|0.00562
rs267603605	chr12	57864243	57864243	G	A	exonic	GLI1	nonsynonymous	LUAD\|6\|543\|0.01105
-	chr12	57857555	57857555	C	A	exonic	GLI1	synonymous	LUSC\|1\|178\|0.00562
-	chr12	57859454	57859454	C	G	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57865164	57865164	C	T	exonic	GLI1	synonymous	SKCM\|2\|368\|0.00543
-	chr12	57860105	57860105	T	A	exonic	GLI1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	57863427	57863427	C	G	exonic	GLI1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	57859404	57859404	G	A	exonic	GLI1	synonymous	SARC\|1\|247\|0.00405
-	chr12	57858456	57858456	G	A	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57858517	57858517	C	G	exonic	GLI1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	57865761	57865761	C	-	exonic	GLI1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LIHC\|1\|373\|0.00268
-	chr12	57864530	57864530	G	T	exonic	GLI1	synonymous	LUSC\|1\|178\|0.00562
-	chr12	57858618	57858618	G	A	exonic	GLI1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs760141461	chr12	57858560	57858560	C	T	exonic	GLI1	nonsynonymous	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184
rs148571068	chr12	57858942	57858942	G	A	exonic	GLI1	synonymous	UCEC\|1\|248\|0.00403
-	chr12	57865815	57865815	G	T	exonic	GLI1	stopgain	SKCM\|1\|368\|0.00272
-	chr12	57861878	57861878	G	-	exonic	GLI1	frameshift	CESC\|1\|194\|0.00515
-	chr12	57865375	57865375	G	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57865571	57865571	G	A	exonic	GLI1	synonymous	ESCA\|1\|185\|0.00541
-	chr12	57860033	57860033	G	A	exonic	GLI1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	57865676	57865676	T	C	exonic	GLI1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57861990	57861990	G	C	exonic	GLI1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs753380800	chr12	57858503	57858503	C	T	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57863320	57863320	G	A	exonic	GLI1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr12	57865760	57865760	G	C	exonic	GLI1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57861784	57861784	A	G	exonic	GLI1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	57859650	57859650	C	T	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57864213	57864213	C	T	exonic	GLI1	nonsynonymous	PRAD\|1\|499\|0.00200
rs373249560	chr12	57861144	57861144	G	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs368469814	chr12	57865281	57865281	G	A	exonic	GLI1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	57857571	57857571	G	T	exonic	GLI1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57863408	57863408	C	T	exonic	GLI1	synonymous	LUSC\|1\|178\|0.00562
-	chr12	57864247	57864247	C	T	exonic	GLI1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	57864797	57864797	C	T	exonic	GLI1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs756656703	chr12	57859426	57859426	C	T	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57860048	57860048	G	A	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57861257	57861257	C	A	exonic	GLI1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	57860059	57860059	G	A	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57865455	57865455	G	C	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
rs149185944	chr12	57858986	57858986	G	A	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57864151	57864151	G	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs368078339	chr12	57864354	57864354	C	T	exonic	GLI1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	57859013	57859013	C	T	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57865299	57865299	C	T	exonic	GLI1	stopgain	SARC\|1\|247\|0.00405
-	chr12	57865639	57865639	C	T	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	57864125	57864125	C	-	exonic	GLI1	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr12	57864501	57864501	C	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs759027001	chr12	57863392	57863392	G	A	exonic	GLI1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	57864605	57864605	G	T	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57859598	57859598	C	T	exonic	GLI1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	57858605	57858605	A	G	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57859007	57859007	C	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57865553	57865553	C	T	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
rs774148738	chr12	57860074	57860074	-	G	exonic	GLI1	frameshift	KIPAN\|15\|799\|0.01877,KIRC\|15\|451\|0.03326,LUAD\|8\|543\|0.01473
rs200550278	chr12	57865745	57865745	C	A	exonic	GLI1	synonymous	HNSC\|1\|512\|0.00195
-	chr12	57863223	57863223	C	A	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
rs756282060	chr12	57858600	57858600	G	A	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57862003	57862003	C	T	exonic	GLI1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	57863271	57863271	G	T	exonic	GLI1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	57860100	57860100	G	A	exonic	GLI1	synonymous	SKCM\|1\|368\|0.00272
-	chr12	57864360	57864360	G	C	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
rs538595523	chr12	57864433	57864433	G	A	exonic	GLI1	nonsynonymous	OV\|1\|469\|0.00213,UCEC\|1\|248\|0.00403
rs767216717	chr12	57861129	57861129	G	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57865641	57865641	C	T	exonic	GLI1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	57858504	57858504	G	A	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57865042	57865042	G	A	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57861780	57861780	C	T	exonic	GLI1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	57861912	57861912	C	G	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57865439	57865439	A	C	exonic	GLI1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57865362	57865362	A	G	exonic	GLI1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr12	57857804	57857804	C	A	exonic	GLI1	stopgain	LUSC\|1\|178\|0.00562
rs371273350	chr12	57858598	57858598	G	A	exonic	GLI1	synonymous	OV\|1\|469\|0.00213
-	chr12	57865531	57865531	A	C	exonic	GLI1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	57865802	57865802	A	T	exonic	GLI1	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	57865438	57865438	A	-	exonic	GLI1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57863379	57863379	C	G	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253
rs201845227	chr12	57864192	57864192	C	T	exonic	GLI1	nonsynonymous	PRAD\|1\|499\|0.00200,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57861953	57861953	G	T	exonic	GLI1	synonymous	LUAD\|1\|543\|0.00184
-	chr12	57859009	57859009	C	G	exonic	GLI1	nonsynonymous	BLCA\|1\|396\|0.00253,BRCA\|1\|982\|0.00102
-	chr12	57865815	57865815	G	C	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57865753	57865753	C	T	exonic	GLI1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	57859575	57859575	C	T	exonic	GLI1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr12	57858512	57858512	T	C	exonic	GLI1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	57863398	57863398	T	G	exonic	GLI1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	57859467	57859467	C	A	exonic	GLI1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	57864227	57864227	C	T	exonic	GLI1	synonymous	BLCA\|1\|396\|0.00253

Disease information of GLI1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
GLI1	Malignant neoplasm of urinary bladder	C04;C12;C13	Neoplastic Process	CTD_human
GLI1	Bladder Neoplasm	C04;C12;C13	Neoplastic Process	CTD_human
GLI1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	UNIPROT
GLI1	Ellis-Van Creveld Syndrome	C05;C16;C17	Disease or Syndrome	ORPHANET
GLI1	Acute Promyelocytic Leukemia	C04	Neoplastic Process	CTD_human
GLI1	Peripheral Neuropathy	C10	Disease or Syndrome	CTD_human
GLI1	Diffuse Large B-Cell Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
GLI1	Gastrointestinal Stromal Tumors	C04;C06	Neoplastic Process	CTD_human
GLI1	Liver carcinoma	C04;C06	Neoplastic Process	CTD_human
GLI1	Gastrointestinal Stromal Sarcoma	C04;C06	Neoplastic Process	CTD_human

Pathway associated with GLI1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000428	Ci/Gli processing signaling ( Hedgehog signaling pathway )	inoh	17	76
pathway0000578	Degradation of GLI1 by the proteasome	reactome	59	1494
pathway0000756	FAS signaling pathway	panther	37	148
pathway0000907	GLI proteins bind promoters of Hh responsive genes to promote transcription	reactome	7	15
pathway0000992	Hedgehog off state	reactome	43	309
pathway0000993	Hedgehog on state	reactome	72	1642
pathway0000994	Hedgehog	netpath	39	177
pathway0000996	Hedgehog signaling events mediated by Gli proteins	pid	49	297
pathway0000997	Hedgehog signaling pathway	panther	19	82
pathway0002475	Signaling without Hh ( Hedgehog signaling pathway )	inoh	7	20
pathway0002590	Hedgehog signaling pathway	kegg	53	285
pathway0002664	Basal cell carcinoma	kegg	51	551
pathway0002746	Hs_Dopaminergic_Neurogenesis_WP2855_87239	wikipathways	19	37

Go term information of GLI1

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION	BP	GLI1
GO_HINDBRAIN_DEVELOPMENT	BP	GLI1
GO_POSITIVE_REGULATION_OF_DNA_REPLICATION	BP	GLI1
GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT	BP	GLI1
GO_METENCEPHALON_DEVELOPMENT	BP	GLI1
GO_RESPONSE_TO_WOUNDING	BP	GLI1
GO_CEREBELLAR_CORTEX_MORPHOGENESIS	BP	GLI1
GO_REGENERATION	BP	GLI1
GO_PITUITARY_GLAND_DEVELOPMENT	BP	GLI1
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	GLI1
GO_ANATOMICAL_STRUCTURE_REGRESSION	BP	GLI1
GO_CEREBELLAR_CORTEX_DEVELOPMENT	BP	GLI1
GO_DIGESTIVE_TRACT_MORPHOGENESIS	BP	GLI1
GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	GLI1
GO_LIVER_REGENERATION	BP	GLI1
GO_REGULATION_OF_DNA_METABOLIC_PROCESS	BP	GLI1
GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING	BP	GLI1
GO_DIENCEPHALON_DEVELOPMENT	BP	GLI1
GO_HINDBRAIN_MORPHOGENESIS	BP	GLI1
GO_ENDOCRINE_SYSTEM_DEVELOPMENT	BP	GLI1
GO_TUBE_MORPHOGENESIS	BP	GLI1
GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY	BP	GLI1
GO_NOTOCHORD_DEVELOPMENT	BP	GLI1
GO_REGULATION_OF_ORGAN_MORPHOGENESIS	BP	GLI1
GO_CILIARY_TIP	CC	GLI1
GO_CILIARY_BASE	CC	GLI1
GO_CILIARY_PLASM	CC	GLI1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	GLI1
GO_TUBULIN_BINDING	MF	GLI1
GO_CHROMATIN_BINDING	MF	GLI1
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	GLI1

Survival analysis of GLI1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of GLI1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)