TF information
| TF name: | GATA4 |
| TF family: | zf-GATA |
| Ensembl gene ID: | ENSG00000136574 |
| Ensembl protein ID: | ENSP00000435043, ENSP00000435712, ENSP00000435347, ENSP00000482268, ENSP00000334458 |
| Entrez gene ID: | 2626 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of GATA4 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_285 | Cell line | Liver | HuH7_untreat | 0.23344947735192 |
GATA4 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
GATA4 distribution in all CRCs
Genomic distribution of SEs associated with GATA4
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of GATA4
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| rs780419565 | chr8 | 11615867 | 11615867 | G | A | exonic | GATA4 | synonymous | ESCA|1|185|0.00541 |
| rs112435835 | chr8 | 11614559 | 11614559 | A | G | exonic | GATA4 | synonymous | DLBC|1|48|0.02083 |
| rs377673676 | chr8 | 11606439 | 11606439 | G | A | exonic | GATA4 | nonsynonymous | PAAD|1|185|0.00541,SKCM|1|368|0.00272 |
| rs199922907 | chr8 | 11565838 | 11565838 | C | T | exonic | GATA4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr8 | 11614446 | 11614446 | C | T | exonic | GATA4 | nonsynonymous | SKCM|1|368|0.00272 |
| rs755482369 | chr8 | 11614478 | 11614478 | C | T | exonic | GATA4 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr8 | 11607661 | 11607661 | G | T | exonic | GATA4 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr8 | 11607664 | 11607664 | C | A | exonic | GATA4 | synonymous | LUSC|1|178|0.00562 |
| - | chr8 | 11615820 | 11615820 | A | C | exonic | GATA4 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| rs777744927 | chr8 | 11607622 | 11607622 | C | T | exonic | GATA4 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr8 | 11607683 | 11607683 | C | T | exonic | GATA4 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr8 | 11607704 | 11607704 | C | T | exonic | GATA4 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs778818575 | chr8 | 11615852 | 11615852 | C | T | exonic | GATA4 | synonymous | LIHC|1|373|0.00268 |
| - | chr8 | 11606487 | 11606487 | C | A | exonic | GATA4 | nonsynonymous | LUAD|1|543|0.00184 |
| rs757208344 | chr8 | 11607694 | 11607694 | G | A | exonic | GATA4 | synonymous | LUSC|1|178|0.00562 |
| - | chr8 | 11615912 | 11615912 | G | A | exonic | GATA4 | synonymous | BLCA|1|396|0.00253 |
| - | chr8 | 11606458 | 11606458 | A | T | exonic | GATA4 | nonsynonymous | LUAD|1|543|0.00184 |
| rs145999237 | chr8 | 11614530 | 11614530 | C | T | exonic | GATA4 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr8 | 11606502 | 11606502 | G | T | exonic | GATA4 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr8 | 11614473 | 11614473 | G | T | exonic | GATA4 | nonsynonymous | BLCA|1|396|0.00253 |
| rs368098911 | chr8 | 11614472 | 11614472 | C | T | exonic | GATA4 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr8 | 11606509 | 11606509 | C | T | exonic | GATA4 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,PCPG|1|184|0.00543 |
| rs745735974 | chr8 | 11615981 | 11615981 | G | A | exonic | GATA4 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr8 | 11612578 | 11612578 | G | A | exonic | GATA4 | synonymous | SKCM|1|368|0.00272 |
| - | chr8 | 11607632 | 11607632 | C | T | exonic | GATA4 | stopgain | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
| - | chr8 | 11612605 | 11612605 | G | A | exonic | GATA4 | synonymous | SKCM|1|368|0.00272 |
| rs192122549 | chr8 | 11606438 | 11606438 | C | T | exonic | GATA4 | synonymous | DLBC|1|48|0.02083 |
| - | chr8 | 11606535 | 11606535 | G | A | exonic | GATA4 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr8 | 11615832 | 11615832 | G | A | exonic | GATA4 | nonsynonymous | SKCM|1|368|0.00272 |
| rs200167770 | chr8 | 11614510 | 11614510 | C | G | exonic | GATA4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr8 | 11615981 | 11615981 | G | T | exonic | GATA4 | synonymous | LUAD|2|543|0.00368 |
| - | chr8 | 11606499 | 11606499 | C | T | exonic | GATA4 | stopgain | LUAD|1|543|0.00184 |
| - | chr8 | 11612575 | 11612575 | G | A | exonic | GATA4 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr8 | 11615950 | 11615950 | T | C | exonic | GATA4 | nonsynonymous | SARC|1|247|0.00405 |
| rs55633527 | chr8 | 11615887 | 11615887 | C | T | exonic | GATA4 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr8 | 11606581 | 11606581 | C | T | exonic | GATA4 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr8 | 11615948 | 11615948 | C | A | exonic | GATA4 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs745533633 | chr8 | 11607630 | 11607630 | G | A | exonic | GATA4 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr8 | 11606556 | 11606556 | G | A | exonic | GATA4 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189,SKCM|1|368|0.00272 |
| rs201520087 | chr8 | 11607623 | 11607623 | G | A | exonic | GATA4 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
| - | chr8 | 11607724 | 11607724 | C | G | exonic | GATA4 | synonymous | LUAD|6|543|0.01105 |
| - | chr8 | 11607646 | 11607646 | C | T | exonic | GATA4 | synonymous | SKCM|1|368|0.00272 |
| - | chr8 | 11606457 | 11606457 | G | C | exonic | GATA4 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr8 | 11607676 | 11607676 | G | C | exonic | GATA4 | synonymous | LUAD|2|543|0.00368 |
| - | chr8 | 11614576 | 11614576 | G | T | exonic | GATA4 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr8 | 11607705 | 11607705 | C | A | exonic | GATA4 | nonsynonymous | ACC|1|90|0.01111 |
| - | chr8 | 11615827 | 11615827 | G | A | exonic | GATA4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr8 | 11615843 | 11615843 | C | T | exonic | GATA4 | synonymous | SKCM|1|368|0.00272 |
| - | chr8 | 11606472 | 11606472 | G | T | exonic | GATA4 | nonsynonymous | LUAD|1|543|0.00184 |
| rs376885265 | chr8 | 11615818 | 11615818 | C | T | exonic | GATA4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr8 | 11565860 | 11565860 | - | C | exonic | GATA4 | frameshift | KIPAN|2|799|0.00250,KIRC|2|451|0.00443 |
| - | chr8 | 11607646 | 11607646 | C | G | exonic | GATA4 | synonymous | LUSC|1|178|0.00562 |
| - | chr8 | 11615844 | 11615844 | C | T | exonic | GATA4 | nonsynonymous | SKCM|1|368|0.00272 |
| rs781198110 | chr8 | 11614543 | 11614543 | C | T | exonic | GATA4 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,UCS|1|57|0.01754 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| GATA4 | Alcohol Use Disorder | C25;F03 | Mental or Behavioral Dysfunction | CTD_human |
| GATA4 | Alcoholic Intoxication, Chronic | C25;F03 | Mental or Behavioral Dysfunction | CTD_human |
| GATA4 | Colorectal Carcinoma | C04;C06 | Neoplastic Process | CTD_human |
| GATA4 | Colorectal Neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| GATA4 | Cardiomegaly | C14;C23 | Finding | CTD_human |
| GATA4 | Ventricular Septal Defects | C14;C16 | Congenital Abnormality | CTD_human |
| GATA4 | Diaphragmatic Hernia | C23 | Anatomical Abnormality | CTD_human |
| GATA4 | Myocardial Infarction | C14 | Disease or Syndrome | CTD_human |
| GATA4 | Disorders of Sex Development | C12;C13;C16;C19 | Congenital Abnormality | GENOMICS_ENGLAND |
| GATA4 | Tetralogy of Fallot | C14;C16 | Congenital Abnormality | CTD_human;ORPHANET;UNIPROT |
| GATA4 | Alcohol abuse | C25;F03 | Mental or Behavioral Dysfunction | CTD_human |
| GATA4 | Congenital diaphragmatic hernia | C16;C23 | Disease or Syndrome | CTD_human |
| GATA4 | Congenital hernia of foramen of Morgagni | C16;C23 | Congenital Abnormality | CTD_human |
| GATA4 | Congenital hernia of foramen of Bochdalek | C16;C23 | Congenital Abnormality | CTD_human |
| GATA4 | Ostium secundum atrial septal defect | C14;C16 | Congenital Abnormality | ORPHANET |
| GATA4 | Partial atrioventricular canal | C14;C16 | Congenital Abnormality | ORPHANET |
| GATA4 | Cardiac Hypertrophy | C14;C23 | Pathologic Function | CTD_human |
| GATA4 | ATRIOVENTRICULAR CANAL DEFECT | C14;C16 | Anatomical Abnormality | CTD_human |
| GATA4 | Atrioventricular Septal Defect | C14;C16 | Congenital Abnormality | CTD_human |
| GATA4 | Colorectal Cancer | C04;C06 | Neoplastic Process | CTD_human |
| GATA4 | Atrial septal defect 2 | C14;C16 | Congenital Abnormality; Disease or Syndrome | CTD_human;UNIPROT |
| GATA4 | ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) | C14;C23 | Disease or Syndrome | ORPHANET |
| GATA4 | Chromosome 8, monosomy 8p23 1 | C23 | Disease or Syndrome | ORPHANET |
| GATA4 | VENTRICULAR SEPTAL DEFECT 1 | Congenital Abnormality; Disease or Syndrome | UNIPROT | |
| GATA4 | ATRIOVENTRICULAR SEPTAL DEFECT 4 | Congenital Abnormality; Disease or Syndrome | UNIPROT | |
| GATA4 | Intellectual Disability | C10;C23;F01;F03 | Mental or Behavioral Dysfunction | GENOMICS_ENGLAND |
| GATA4 | TESTICULAR ANOMALIES WITH OR WITHOUT CONGENITAL HEART DISEASE | Disease or Syndrome | CTD_human;UNIPROT | |
| GATA4 | 46,XY partial gonadal dysgenesis | Disease or Syndrome | ORPHANET |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000747 | Factors involved in megakaryocyte development and platelet production | reactome | 111 | 689 |
| pathway0001516 | Notch-mediated HES/HEY network | pid | 48 | 337 |
| pathway0001649 | Physiological factors | reactome | 12 | 24 |
| pathway0002182 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 | 22 |
| pathway0002460 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 | 144 |
| pathway0002740 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 | 260 |
| pathway0002768 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 | 78 |
| pathway0002834 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 | 27 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS | BP | GATA4 |
| GO_ENDOCARDIAL_CUSHION_DEVELOPMENT | BP | GATA4 |
| GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS | BP | GATA4 |
| GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS | BP | GATA4 |
| GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION | BP | GATA4 |
| GO_REGULATION_OF_HEART_CONTRACTION | BP | GATA4 |
| GO_NEGATIVE_REGULATION_OF_AUTOPHAGY | BP | GATA4 |
| GO_EMBRYO_DEVELOPMENT | BP | GATA4 |
| GO_DIGESTIVE_SYSTEM_DEVELOPMENT | BP | GATA4 |
| GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY | BP | GATA4 |
| GO_CARDIAC_ATRIUM_DEVELOPMENT | BP | GATA4 |
| GO_ATRIAL_SEPTUM_DEVELOPMENT | BP | GATA4 |
| GO_ATRIAL_SEPTUM_MORPHOGENESIS | BP | GATA4 |
| GO_MUSCLE_STRUCTURE_DEVELOPMENT | BP | GATA4 |
| GO_CARDIAC_VENTRICLE_MORPHOGENESIS | BP | GATA4 |
| GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION | BP | GATA4 |
| GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | GATA4 |
| GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS | BP | GATA4 |
| GO_DIGESTIVE_TRACT_MORPHOGENESIS | BP | GATA4 |
| GO_ORGAN_GROWTH | BP | GATA4 |
| GO_CARDIAC_VENTRICLE_DEVELOPMENT | BP | GATA4 |
| GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION | BP | GATA4 |
| GO_EMBRYONIC_MORPHOGENESIS | BP | GATA4 |
| GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT | BP | GATA4 |
| GO_RESPONSE_TO_VITAMIN_A | BP | GATA4 |
| GO_CELLULAR_GLUCOSE_HOMEOSTASIS | BP | GATA4 |
| GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION | BP | GATA4 |
| GO_RESPONSE_TO_DRUG | BP | GATA4 |
| GO_CARDIOCYTE_DIFFERENTIATION | BP | GATA4 |
| GO_MUSCLE_HYPERTROPHY | BP | GATA4 |
| GO_DEVELOPMENTAL_CELL_GROWTH | BP | GATA4 |
| GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT | BP | GATA4 |
| GO_HEART_GROWTH | BP | GATA4 |
| GO_CARDIAC_SEPTUM_MORPHOGENESIS | BP | GATA4 |
| GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY | BP | GATA4 |
| GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS | BP | GATA4 |
| GO_CIRCULATORY_SYSTEM_DEVELOPMENT | BP | GATA4 |
| GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS | BP | GATA4 |
| GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION | BP | GATA4 |
| GO_REGULATION_OF_BLOOD_CIRCULATION | BP | GATA4 |
| GO_CARDIAC_CELL_DEVELOPMENT | BP | GATA4 |
| GO_REGULATION_OF_VASCULATURE_DEVELOPMENT | BP | GATA4 |
| GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX | CC | GATA4 |
| GO_TRANSCRIPTION_FACTOR_COMPLEX | CC | GATA4 |
| GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX | CC | GATA4 |
| GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING | MF | GATA4 |
| GO_CO_SMAD_BINDING | MF | GATA4 |
| GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING | MF | GATA4 |
| GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING | MF | GATA4 |