Cancer CRCdb

TF information

TF name:	ESR2
TF family:	ESR-like
Ensembl gene ID:	ENSG00000140009
Ensembl protein ID:	ENSP00000450488, ENSP00000451582, ENSP00000335551, ENSP00000267525, ENSP00000343925, ENSP00000351412, ENSP00000345616, ENSP00000450699, ENSP00000452426, ENSP00000452485
Entrez gene ID:	2100

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ESR2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.59166666666667

ESR2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

ESR2 distribution in all CRCs

Genomic distribution of SEs associated with ESR2

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Mutation of ESR2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ESR2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr14	64727411	64727411	G	T	exonic	ESR2	nonsynonymous	LUAD\|1\|543\|0.00184
rs758569519	chr14	64699873	64699873	C	T	exonic	ESR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	64724074	64724074	C	T	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	64727309	64727309	G	A	exonic	ESR2	synonymous	BLCA\|1\|396\|0.00253
-	chr14	64723949	64723949	C	T	exonic	ESR2	synonymous	SKCM\|1\|368\|0.00272
-	chr14	64724059	64724059	C	T	exonic	ESR2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	64727439	64727439	C	A	exonic	ESR2	nonsynonymous	LUSC\|1\|178\|0.00562
rs745947456	chr14	64716381	64716381	C	T	exonic	ESR2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs139503857	chr14	64749412	64749412	G	A	exonic	ESR2	synonymous	SKCM\|1\|368\|0.00272
rs772629994	chr14	64716327	64716327	G	A	exonic	ESR2	stopgain	HNSC\|1\|512\|0.00195
-	chr14	64727423	64727423	C	T	exonic	ESR2	synonymous	LUAD\|1\|543\|0.00184
rs374713642	chr14	64699906	64699906	C	T	exonic	ESR2	synonymous	SKCM\|1\|368\|0.00272
rs138379290	chr14	64694323	64694323	C	T	exonic	ESR2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64727461	64727461	G	T	exonic	ESR2	synonymous	LIHC\|1\|373\|0.00268
-	chr14	64724058	64724058	T	C	exonic	ESR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs768749310	chr14	64701804	64701804	C	G	exonic	ESR2	synonymous	BLCA\|1\|396\|0.00253
rs145661652	chr14	64724049	64724049	C	T	exonic	ESR2	nonsynonymous	BLCA\|1\|396\|0.00253
rs368924653	chr14	64735545	64735545	C	T	exonic	ESR2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64701829	64701829	C	A	exonic	ESR2	nonsynonymous	UCEC\|1\|248\|0.00403
rs760612953	chr14	64746774	64746774	C	T	exonic	ESR2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	64723980	64723980	C	T	exonic	ESR2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr14	64699866	64699866	G	-	exonic	ESR2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs147382781	chr14	64749427	64749427	G	A	exonic	ESR2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr14	64724025	64724025	T	A	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	64749606	64749606	G	A	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
rs543025691	chr14	64727365	64727365	C	T	exonic	ESR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr14	64749457	64749457	G	T	exonic	ESR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr14	64735629	64735629	C	T	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
rs763840228	chr14	64746775	64746775	G	A	exonic	ESR2	synonymous	HNSC\|1\|512\|0.00195
-	chr14	64735576	64735576	G	A	exonic	ESR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs141516067	chr14	64749369	64749369	G	A	exonic	ESR2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,SKCM\|2\|368\|0.00543
-	chr14	64699872	64699872	T	A	exonic	ESR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64727249	64727249	G	A	exonic	ESR2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64749598	64749598	A	G	exonic	ESR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs766292098	chr14	64694263	64694263	C	T	exonic	ESR2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64727213	64727213	G	A	exonic	ESR2	synonymous	ESCA\|2\|185\|0.01081
-	chr14	64716295	64716295	G	A	exonic	ESR2	synonymous	SKCM\|1\|368\|0.00272
-	chr14	64699876	64699876	G	A	exonic	ESR2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64746749	64746749	C	G	exonic	ESR2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr14	64694310	64694310	G	C	exonic	ESR2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	64749427	64749427	G	T	exonic	ESR2	nonsynonymous	CHOL\|1\|35\|0.02857
rs757686092	chr14	64699862	64699862	G	A	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	64727460	64727460	C	T	exonic	ESR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs145033525	chr14	64749623	64749623	G	A	exonic	ESR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs750886730	chr14	64727336	64727336	G	A	exonic	ESR2	synonymous	PAAD\|1\|185\|0.00541,UCEC\|1\|248\|0.00403
-	chr14	64749466	64749466	A	G	exonic	ESR2	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr14	64724039	64724039	C	T	exonic	ESR2	synonymous	SKCM\|1\|368\|0.00272
rs774742997	chr14	64746834	64746834	C	T	exonic	ESR2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr14	64716368	64716368	A	G	exonic	ESR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64727335	64727335	C	T	exonic	ESR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184
-	chr14	64723981	64723981	C	A	exonic	ESR2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	64735549	64735549	G	T	exonic	ESR2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr14	64716374	64716374	C	T	exonic	ESR2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	64727440	64727440	G	A	exonic	ESR2	nonsynonymous	BRCA\|1\|982\|0.00102
rs144392940	chr14	64701762	64701762	G	A	exonic	ESR2	synonymous	PRAD\|1\|499\|0.00200
rs145278854	chr14	64735585	64735585	C	T	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	64746790	64746790	G	A	exonic	ESR2	synonymous	HNSC\|2\|512\|0.00391
-	chr14	64694316	64694316	G	C	exonic	ESR2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	64701717	64701717	C	T	exonic	ESR2	synonymous	BLCA\|1\|396\|0.00253
-	chr14	64749642	64749642	G	A	exonic	ESR2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr14	64699969	64699969	C	A	exonic	ESR2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr14	64746761	64746761	C	T	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	64746715	64746715	A	T	exonic	ESR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64727386	64727386	C	T	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
rs553390407	chr14	64724010	64724010	C	T	exonic	ESR2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr14	64735616	64735616	A	G	exonic	ESR2	synonymous	LUAD\|1\|543\|0.00184
rs2229618	chr14	64701857	64701857	G	C	exonic	ESR2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	64727201	64727201	C	A	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	64727172	64727172	A	T	exonic	ESR2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr14	64746820	64746820	A	G	exonic	ESR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs556956556	chr14	64735534	64735534	C	T	exonic	ESR2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	64749567	64749567	A	G	exonic	ESR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64727212	64727212	C	T	exonic	ESR2	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr14	64727439	64727439	C	T	exonic	ESR2	nonsynonymous	PAAD\|1\|185\|0.00541
rs143949374	chr14	64727347	64727347	G	A	exonic	ESR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	64727429	64727429	C	T	exonic	ESR2	synonymous	SKCM\|1\|368\|0.00272
-	chr14	64746747	64746747	C	T	exonic	ESR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr14	64746795	64746795	G	A	exonic	ESR2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	64735513	64735513	C	A	exonic	ESR2	nonsynonymous	OV\|1\|469\|0.00213
rs749478587	chr14	64746760	64746760	T	G	exonic	ESR2	synonymous	BRCA\|1\|982\|0.00102
-	chr14	64700034	64700034	C	T	exonic	ESR2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr14	64735613	64735613	A	C	exonic	ESR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	64727379	64727379	C	T	exonic	ESR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	64746715	64746715	A	-	exonic	ESR2	frameshift	PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	64727260	64727260	C	T	exonic	ESR2	nonsynonymous	OV\|1\|469\|0.00213
-	chr14	64727316	64727316	A	G	exonic	ESR2	nonsynonymous	LIHC\|1\|373\|0.00268
rs141940742	chr14	64699953	64699953	C	T	exonic	ESR2	nonsynonymous	UCEC\|1\|248\|0.00403
rs747912769	chr14	64723982	64723982	G	A	exonic	ESR2	synonymous	ESCA\|1\|185\|0.00541
-	chr14	64746800	64746800	T	C	exonic	ESR2	nonsynonymous	ESCA\|1\|185\|0.00541
rs528840784	chr14	64699947	64699947	G	A	exonic	ESR2	nonsynonymous	LUAD\|6\|543\|0.01105
-	chr14	64723960	64723960	C	A	exonic	ESR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs761268108	chr14	64727453	64727453	C	T	exonic	ESR2	synonymous	HNSC\|1\|512\|0.00195
-	chr14	64716389	64716389	C	T	exonic	ESR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	64724059	64724059	C	G	exonic	ESR2	nonsynonymous	LUSC\|1\|178\|0.00562
rs147847668	chr14	64716388	64716388	C	T	exonic	ESR2	synonymous	UCEC\|1\|248\|0.00403
-	chr14	64727199	64727199	A	G	exonic	ESR2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr14	64701791	64701791	C	A	exonic	ESR2	nonsynonymous	BLCA\|1\|396\|0.00253

Disease information of ESR2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ESR2	Adenocarcinoma	C04	Neoplastic Process	CTD_human
ESR2	Cardiac Arrhythmia	C14;C23	Finding	CTD_human
ESR2	Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Malignant neoplasm of urinary bladder	C04;C12;C13	Neoplastic Process	CTD_human
ESR2	Bladder Neoplasm	C04;C12;C13	Neoplastic Process	CTD_human
ESR2	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
ESR2	Carcinoma	C04	Neoplastic Process	CTD_human
ESR2	Carcinoma, Transitional Cell	C04	Neoplastic Process	CTD_human
ESR2	Cocaine Abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ESR2	Colorectal Carcinoma	C04;C06	Neoplastic Process	CTD_human
ESR2	Colorectal Neoplasms	C04;C06	Neoplastic Process	CTD_human
ESR2	Coronary Arteriosclerosis	C14	Disease or Syndrome	CTD_human
ESR2	Coronary heart disease	C14	Disease or Syndrome	CTD_human
ESR2	Endometrial Neoplasms	C04;C13	Neoplastic Process	CTD_human
ESR2	Endometriosis	C13	Disease or Syndrome	CTD_human
ESR2	Female infertility	C13	Pathologic Function	CTD_human
ESR2	Lithiasis	C23	Pathologic Function	CTD_human
ESR2	Animal Mammary Neoplasms	C04;C22	Neoplastic Process	CTD_human
ESR2	Mammary Neoplasms, Experimental	C04	Experimental Model of Disease; Neoplastic Process	CTD_human
ESR2	Medulloblastoma	C04	Neoplastic Process	CTD_human
ESR2	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
ESR2	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR2	Sterility, Postpartum	C13	Pathologic Function	CTD_human
ESR2	Unipolar Depression	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR2	Adenocarcinoma, Basal Cell	C04	Neoplastic Process	CTD_human
ESR2	Adenocarcinoma, Oxyphilic	C04	Neoplastic Process	CTD_human
ESR2	Carcinoma, Cribriform	C04	Neoplastic Process	CTD_human
ESR2	Carcinoma, Granular Cell	C04	Neoplastic Process	CTD_human
ESR2	Adenocarcinoma, Tubular	C04	Neoplastic Process	CTD_human
ESR2	Anaplastic carcinoma	C04	Neoplastic Process	CTD_human
ESR2	Carcinoma, Spindle-Cell	C04	Neoplastic Process	CTD_human
ESR2	Undifferentiated carcinoma	C04	Neoplastic Process	CTD_human
ESR2	Carcinomatosis	C04	Neoplastic Process	CTD_human
ESR2	Subependymal Giant Cell Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Medullomyoblastoma	C04	Neoplastic Process	CTD_human
ESR2	Cocaine-Related Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ESR2	Endometrioma	C13	Neoplastic Process	CTD_human
ESR2	Childhood Medulloblastoma	C04	Neoplastic Process	CTD_human
ESR2	Adult Medulloblastoma	C04	Neoplastic Process	CTD_human
ESR2	Juvenile Pilocytic Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Diffuse Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Prostatic Intraepithelial Neoplasias	C04	Neoplastic Process	CTD_human
ESR2	Anaplastic astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Protoplasmic astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Gemistocytic astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Fibrillary Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Pilocytic Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Childhood Cerebral Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Subfertility, Female	C13	Disease or Syndrome	CTD_human
ESR2	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
ESR2	Endometrial Carcinoma	C04;C13	Neoplastic Process	CTD_human
ESR2	Mixed oligoastrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Severe depression		Mental or Behavioral Dysfunction	PSYGENET
ESR2	Cocaine Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ESR2	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
ESR2	Cerebral Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Intracranial Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Desmoplastic Medulloblastoma	C04	Neoplastic Process	CTD_human
ESR2	Female sterility	C13	Finding	CTD_human
ESR2	Mammary Carcinoma, Animal	C04;C22	Neoplastic Process	CTD_human
ESR2	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
ESR2	Major Depressive Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR2	Melanotic medulloblastoma	C04	Neoplastic Process	CTD_human
ESR2	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
ESR2	Colorectal Cancer	C04;C06	Neoplastic Process	CTD_human
ESR2	Grade I Astrocytoma	C04	Neoplastic Process	CTD_human
ESR2	Familial medullary thyroid carcinoma	C04;C16;C19	Neoplastic Process	ORPHANET
ESR2	Coronary Artery Disease	C14	Disease or Syndrome	CTD_human
ESR2	Familial M?ni?re disease		Disease or Syndrome	GENOMICS_ENGLAND

Pathway associated with ESR2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001534	Nuclear Receptor transcription pathway	reactome	51	284
pathway0001674	Plasma membrane estrogen receptor signaling	pid	42	384
pathway0002388	Validated nuclear estrogen receptor alpha network	pid	65	386
pathway0002389	Validated nuclear estrogen receptor beta network	pid	15	35

Go term information of ESR2

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GO_term_name	GO_term_type	TF_name
GO_HINDBRAIN_DEVELOPMENT	BP	ESR2
GO_RESPONSE_TO_ETHANOL	BP	ESR2
GO_METENCEPHALON_DEVELOPMENT	BP	ESR2
GO_SINGLE_ORGANISM_BEHAVIOR	BP	ESR2
GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY	BP	ESR2
GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION	BP	ESR2
GO_REGULATION_OF_VASODILATION	BP	ESR2
GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	ESR2
GO_SERTOLI_CELL_DEVELOPMENT	BP	ESR2
GO_RESPONSE_TO_PHENYLPROPANOID	BP	ESR2
GO_POSITIVE_REGULATION_OF_MAPK_CASCADE	BP	ESR2
GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY	BP	ESR2
GO_OVULATION_CYCLE	BP	ESR2
GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS	BP	ESR2
GO_POSITIVE_REGULATION_OF_VASODILATION	BP	ESR2
GO_HYPOTHALAMUS_DEVELOPMENT	BP	ESR2
GO_OVARIAN_FOLLICLE_DEVELOPMENT	BP	ESR2
GO_RESPONSE_TO_TESTOSTERONE	BP	ESR2
GO_REGULATION_OF_BEHAVIOR	BP	ESR2
GO_REGULATION_OF_FEEDING_BEHAVIOR	BP	ESR2
GO_FEAR_RESPONSE	BP	ESR2
GO_OVULATION_CYCLE_PROCESS	BP	ESR2
GO_RESPONSE_TO_INSECTICIDE	BP	ESR2
GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS	BP	ESR2
GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	ESR2
GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION	BP	ESR2
GO_FEMALE_SEX_DIFFERENTIATION	BP	ESR2
GO_NEGATIVE_REGULATION_OF_BEHAVIOR	BP	ESR2
GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	ESR2
GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY	BP	ESR2
GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS	BP	ESR2
GO_RESPONSE_TO_DEXAMETHASONE	BP	ESR2
GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS	BP	ESR2
GO_RESPONSE_TO_SALT	BP	ESR2
GO_PROSTATE_GLAND_DEVELOPMENT	BP	ESR2
GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY	BP	ESR2
GO_RESPONSE_TO_GONADOTROPIN	BP	ESR2
GO_SERTOLI_CELL_DIFFERENTIATION	BP	ESR2
GO_RESPONSE_TO_ALCOHOL	BP	ESR2
GO_RESPONSE_TO_WATER	BP	ESR2
GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM	BP	ESR2
GO_RESPONSE_TO_WATER_DEPRIVATION	BP	ESR2
GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS	BP	ESR2
GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY	BP	ESR2
GO_ESTROUS_CYCLE	BP	ESR2
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	ESR2
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY	MF	ESR2
GO_HORMONE_BINDING	MF	ESR2
GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING	MF	ESR2
GO_RECEPTOR_ACTIVITY	MF	ESR2
GO_RECEPTOR_REGULATOR_ACTIVITY	MF	ESR2
GO_RECEPTOR_INHIBITOR_ACTIVITY	MF	ESR2

Survival analysis of ESR2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ESR2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)