Cancer CRCdb

TF information

TF name:	EGR3
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000179388
Ensembl protein ID:	ENSP00000318057, ENSP00000430310
Entrez gene ID:	1960

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of EGR3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.53260869565217
Sample_02_242	Cell line	Colon	V481	0.097641479202717

EGR3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1

EGR3 distribution in all CRCs

Genomic distribution of SEs associated with EGR3

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Mutation of EGR3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of EGR3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr8	22548571	22548571	G	A	exonic	EGR3	synonymous	UCEC\|1\|248\|0.00403
-	chr8	22548606	22548606	C	A	exonic	EGR3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr8	22548691	22548691	G	C	exonic	EGR3	synonymous	BLCA\|1\|396\|0.00253
-	chr8	22548460	22548460	G	-	exonic	EGR3	frameshift	BRCA\|1\|982\|0.00102
-	chr8	22550362	22550362	C	T	exonic	EGR3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548102	22548102	G	A	exonic	EGR3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22548167	22548167	G	A	exonic	EGR3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr8	22548379	22548379	C	-	exonic	EGR3	frameshift	BRCA\|1\|982\|0.00102
rs749768945	chr8	22548021	22548021	-	G	exonic	EGR3	frameshift	BRCA\|2\|982\|0.00204
-	chr8	22548538	22548538	G	A	exonic	EGR3	synonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr8	22550417	22550417	C	T	exonic	EGR3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr8	22548772	22548772	C	T	exonic	EGR3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22548292	22548292	G	C	exonic	EGR3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	22548239	22548239	G	A	exonic	EGR3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	22548495	22548495	G	C	exonic	EGR3	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	22548630	22548630	G	-	exonic	EGR3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22548479	22548479	G	C	exonic	EGR3	nonsynonymous	SKCM\|1\|368\|0.00272
rs370729228	chr8	22548754	22548754	T	C	exonic	EGR3	synonymous	LUAD\|1\|543\|0.00184
-	chr8	22548553	22548553	G	T	exonic	EGR3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	22548290	22548290	C	T	exonic	EGR3	nonsynonymous	SKCM\|1\|368\|0.00272
rs774527739	chr8	22551580	22551580	-	G	upstream	EGR3	unknown	LUAD\|1\|543\|0.00184
rs375168773	chr8	22550452	22550452	G	A	exonic	EGR3	synonymous	PAAD\|1\|185\|0.00541
-	chr8	22548132	22548132	G	T	exonic	EGR3	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr8	22548215	22548215	C	T	exonic	EGR3	nonsynonymous	LIHC\|1\|373\|0.00268,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22550321	22550321	T	C	exonic	EGR3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548617	22548617	G	A	exonic	EGR3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22548734	22548734	G	A	exonic	EGR3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	22548006	22548006	C	T	exonic	EGR3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548547	22548547	G	A	exonic	EGR3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22548028	22548028	C	T	exonic	EGR3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548722	22548722	G	A	exonic	EGR3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	22548017	22548017	G	A	exonic	EGR3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	22548883	22548883	G	A	exonic	EGR3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22548418	22548418	G	T	exonic	EGR3	synonymous	LUSC\|1\|178\|0.00562
-	chr8	22550311	22550311	C	T	exonic	EGR3	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr8	22548815	22548815	C	T	exonic	EGR3	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr8	22548994	22548994	C	G	exonic	EGR3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr8	22548564	22548564	G	T	exonic	EGR3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	22548882	22548882	C	A	exonic	EGR3	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	22548994	22548994	C	A	exonic	EGR3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	22548009	22548009	G	A	exonic	EGR3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	22548748	22548748	C	A	exonic	EGR3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548122	22548122	G	A	exonic	EGR3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548114	22548114	C	G	exonic	EGR3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	22548283	22548283	C	T	exonic	EGR3	synonymous	UCEC\|1\|248\|0.00403
-	chr8	22548613	22548613	G	C	exonic	EGR3	synonymous	BLCA\|1\|396\|0.00253
-	chr8	22548788	22548788	C	T	exonic	EGR3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	22547822	22547822	G	A	UTR3	EGR3	unknown	CESC\|1\|194\|0.00515
-	chr8	22548549	22548549	-	G	exonic	EGR3	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548604	22548604	C	T	exonic	EGR3	synonymous	BRCA\|1\|982\|0.00102
-	chr8	22548693	22548693	G	T	exonic	EGR3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22548299	22548299	C	T	exonic	EGR3	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	22548712	22548712	G	-	exonic	EGR3	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	22548608	22548608	G	A	exonic	EGR3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	22548112	22548112	G	C	exonic	EGR3	nonsynonymous	LUAD\|1\|543\|0.00184
rs777341372	chr8	22548953	22548953	G	T	exonic	EGR3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	22547685	22547685	C	T	UTR3	EGR3	unknown	ESCA\|1\|185\|0.00541
-	chr8	22548121	22548121	C	T	exonic	EGR3	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	22548147	22548147	A	T	exonic	EGR3	nonsynonymous	ACC\|1\|90\|0.01111
-	chr8	22548381	22548381	G	C	exonic	EGR3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	22548403	22548403	C	T	exonic	EGR3	synonymous	UCEC\|1\|248\|0.00403
-	chr8	22548312	22548312	C	T	exonic	EGR3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	22548865	22548865	G	-	exonic	EGR3	frameshift	BRCA\|1\|982\|0.00102,TGCT\|1\|155\|0.00645
-	chr8	22548785	22548785	G	A	exonic	EGR3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr8	22548093	22548093	T	C	exonic	EGR3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of EGR3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
EGR3	Ataxia	C10;C23	Sign or Symptom	CTD_human
EGR3	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
EGR3	Mental Depression	F01	Mental or Behavioral Dysfunction	PSYGENET
EGR3	Depressive disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
EGR3	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
EGR3	Ataxia, Sensory	C10;C23	Sign or Symptom	CTD_human
EGR3	Ataxia, Motor	C10;C23	Finding	CTD_human
EGR3	Ataxia, Truncal	C10;C23	Sign or Symptom	CTD_human
EGR3	Abnormal coordination	C10;C23	Finding	CTD_human
EGR3	Ataxia, Appendicular	C10;C23	Finding	CTD_human
EGR3	Tremor, Rubral	C10;C23	Disease or Syndrome	CTD_human

Pathway associated with EGR3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000343	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	pid	50	304

Go term information of EGR3

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GO_term_name	GO_term_type	TF_name
GO_CIRCADIAN_RHYTHM	BP	EGR3
GO_REGULATION_OF_CELL_ACTIVATION	BP	EGR3
GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS	BP	EGR3
GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION	BP	EGR3
GO_AMEBOIDAL_TYPE_CELL_MIGRATION	BP	EGR3
GO_ENDOTHELIAL_CELL_MIGRATION	BP	EGR3
GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION	BP	EGR3
GO_REGULATION_OF_THYMOCYTE_AGGREGATION	BP	EGR3
GO_SPROUTING_ANGIOGENESIS	BP	EGR3
GO_POSITIVE_REGULATION_OF_CELL_ADHESION	BP	EGR3
GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT	BP	EGR3
GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION	BP	EGR3
GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION	BP	EGR3
GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS	BP	EGR3

Survival analysis of EGR3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of EGR3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)