TF information

TF name: CREB3
TF family: TF_bZIP
Ensembl gene ID: ENSG00000107175
Ensembl protein ID: ENSP00000342136
Entrez gene ID: 10488
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of CREB3 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_268Cell lineKidneyA-4980.091378992062027

CREB3 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

CREB3 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with CREB3
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Mutation of CREB3
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of CREB3

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr93573309735733097CTexonicCREB3synonymous ESCA|1|185|0.00541
rs766535577chr93573343535733435TCexonicCREB3synonymous PAAD|1|185|0.00541
-chr93573608335736083TCexonicCREB3nonsynonymous LIHC|1|373|0.00268
-chr93573611935736119CGexonicCREB3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr93573533735735337CTexonicCREB3stopgain SKCM|1|368|0.00272
-chr93573313735733137CTexonicCREB3synonymous SKCM|1|368|0.00272
-chr93573610435736104CTexonicCREB3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr93573299735732997CGexonicCREB3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr93573639835736398GAexonicCREB3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr93573281535732815CAexonicCREB3nonsynonymous BRCA|1|982|0.00102
-chr93573515935735160TG-exonicCREB3frameshift BLCA|1|396|0.00253
-chr93573650635736506G-exonicCREB3frameshift PRAD|2|499|0.00401
-chr93573347235733472CGexonicCREB3nonsynonymous OV|1|469|0.00213
-chr93573669835736698TCexonicCREB3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr93573310335733103CGexonicCREB3synonymous BRCA|1|982|0.00102
-chr93573513535735135GCexonicCREB3synonymous BLCA|1|396|0.00253
rs141288812chr93573514535735145CTexonicCREB3stopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs756797536chr93573299835732998GAexonicCREB3synonymous BLCA|1|396|0.00253
-chr93573629935736299GTexonicCREB3stopgain LUSC|1|178|0.00562
-chr93573656235736562CTexonicCREB3nonsynonymous BLCA|1|396|0.00253
rs754545426chr93573516935735169AGexonicCREB3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr93573531235735312AGexonicCREB3synonymous ACC|1|90|0.01111
-chr93573641235736412CAexonicCREB3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr93573665835736660AGG-exonicCREB3nonframeshift GBMLGG|1|820|0.00122,LGG|1|530|0.00189
rs758225343chr93573608135736081GAexonicCREB3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr93573283935732839GTexonicCREB3nonsynonymous ESCA|1|185|0.00541
-chr93573670235736702GAexonicCREB3synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr93573323235733232GAexonicCREB3nonsynonymous BLCA|1|396|0.00253
-chr93573627335736273CTexonicCREB3nonsynonymous BLCA|1|396|0.00253
-chr93573307835733078CTexonicCREB3nonsynonymous PRAD|1|499|0.00200
-chr93573342135733422AG-exonicCREB3frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204,GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr93573666935736669AGexonicCREB3synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr93573648335736483-AexonicCREB3frameshift KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr93573303735733037GAexonicCREB3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr93573342835733428G-exonicCREB3frameshift LUAD|1|543|0.00184
-chr93573342535733425GAexonicCREB3synonymous HNSC|1|512|0.00195
-chr93573304135733041C-exonicCREB3frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr93573604535736045GAexonicCREB3synonymous UCEC|1|248|0.00403
rs771918577chr93573662335736623GAexonicCREB3nonsynonymous LUSC|1|178|0.00562
rs190901541chr93573646735736467CTexonicCREB3nonsynonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
-chr93573611435736114CTexonicCREB3synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr93573608935736089A-exonicCREB3frameshift PCPG|1|184|0.00543
rs200166825chr93573311635733116CTexonicCREB3nonsynonymous DLBC|1|48|0.02083
-chr93573664435736644ACexonicCREB3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr93573622335736223GAsplicingCREB3splicing COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs376855806chr93573288735732887CTexonicCREB3nonsynonymous BLCA|1|396|0.00253
-chr93573344535733445AGexonicCREB3nonsynonymous LIHC|1|373|0.00268
-chr93573661835736618CGexonicCREB3synonymous BLCA|1|396|0.00253
-chr93573623735736237CTexonicCREB3nonsynonymous CESC|1|194|0.00515
-chr93573627235736272TCexonicCREB3nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr93573530635735306CGexonicCREB3synonymous BLCA|1|396|0.00253
-chr93573648635736486GAexonicCREB3synonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr93573610635736107AG-exonicCREB3frameshift ESCA|1|185|0.00541
-chr93573671635736716CGexonicCREB3stopgain HNSC|1|512|0.00195

Disease information of CREB3
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source

Pathway associated with CREB3
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001005 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway panther 126 1529
pathway0002297 Transcription regulation by bZIP transcription factor panther 42 653
pathway0002627 Melanogenesis kegg 100 1225
pathway0002633 Vasopressin-regulated water reabsorption kegg 35 126
pathway0002642 Huntingtons disease kegg 182 1941
pathway0002662 Prostate cancer kegg 85 1261
pathway0002688 Hs_TYROBP_Causal_Network_WP3945_90843 wikipathways 54 71
pathway0002797 Hs_Lung_fibrosis_WP3624_91475 wikipathways 23 45

Go term information of CREB3
GO_term_name GO_term_type TF_name
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS BP CREB3
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS BP CREB3
GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS BP CREB3
GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS BP CREB3
GO_POSITIVE_REGULATION_OF_LOCOMOTION BP CREB3
GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS BP CREB3
GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL BP CREB3
GO_REGULATION_OF_POSITIVE_CHEMOTAXIS BP CREB3
GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE BP CREB3
GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN BP CREB3
GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE BP CREB3
GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT BP CREB3
GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3
GO_MAINTENANCE_OF_LOCATION_IN_CELL BP CREB3
GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION BP CREB3
GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3
GO_REGULATION_OF_CALCIUM_ION_TRANSPORT BP CREB3
GO_CHONDROCYTE_DIFFERENTIATION BP CREB3
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS BP CREB3
GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR BP CREB3
GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING BP CREB3
GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS BP CREB3
GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY BP CREB3
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS BP CREB3
GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3
GO_VIRAL_LATENCY BP CREB3
GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN BP CREB3
GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS BP CREB3
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS BP CREB3
GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST BP CREB3
GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS BP CREB3
GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3
GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS BP CREB3
GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN BP CREB3
GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS BP CREB3
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS BP CREB3
GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER BP CREB3
GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY BP CREB3
GO_ENDOPLASMIC_RETICULUM CC CREB3
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING MF CREB3
GO_CAMP_RESPONSE_ELEMENT_BINDING MF CREB3
GO_CCR_CHEMOKINE_RECEPTOR_BINDING MF CREB3
GO_CHEMOKINE_RECEPTOR_BINDING MF CREB3

Survival analysis of CREB3



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of CREB3