Welcome to LncSEA a comprehensive human lncRNA sets resource and enrichment analysis platform.

  • LncSEA supports more than 40,000 reference lncRNA sets involved in 18 categories (miRNA , drug , disease , methylation pattern, cancer specific phenotype, lncRNA binding protein, cancer hallmark, subcellular localization, survival, lncRNA-eQTL, cell marker, enhancer, super-enhancer, transcription factor, accessible chromatin, smORF, exosome and conservation) and 66 sub-categories, which covered over 50,000 lncRNAs. We not only collected lncRNA sets based on downstream regulatory data sources but also calculated a large number of lncRNA sets regulated by upstream transcription factors (TFs) and DNA regulatory elements by integrating TF ChIP-seq, DNase-seq, ATAC-seq and H3K27ac ChIP-seq data associated with hundreds of human cell types.
    Importantly, LncSEA provides annotation and enrichment analysis functions of lncRNA sets associated with upstream regulators and downstream targets. In addition, LncSEA provides a user-friendly interface to search, browse and visualize detailed information about these lncRNA sets. In summary, LncSEA is a powerful platform that provides a variety of types of lncRNA sets for users and supports lncRNA annotation and enrichment analysis functions.
Data statistical table
Class Set LncRNA
Accessible Chromatin 1253 13518
Cancer Hallmark 7 284
Cancer Phenotype 470 13107
Cell Marker 67 452
Disease 1199 7546
Drug 155 11466
Enhancer 1623 13515
EQTL 126 18320
Methylation Pattern 5 91
MiroRNA 1231 6554
RNA Binding Protein 18717 15622
smORF 15 15098
Subcellular Localization 14 13851
Super Enhancer 2150 22980
Survival 33 14387
Transcription Factor 14478 13523
Exosome 1 31
Conservation 18 9830
Contact us

Principal Investigator:Chunquan Li, Ph.D.

Phone: 86-459-8153035

Fax: 86-459-8153035

Email: lcqbio@163.com

School of Medical Informatics,

Daqing Campus Harbin Medical University

39 Xinyang Road, Daqing 163319, China

Sister Projects

SEdb: the comprehensive human Super-Enhancer database

ENdb: an experimentally supported enhancer database for human and mouse

SEanalysis: a web tool for super-enhancer associated regulatory analysis

ATACdb: a comprehensive human chromatin accessibility database

KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors

TRCirc: a resource for transcriptional regulation information of circRNAs

TRlnc: a comprehensive database of human transcriptional regulation of lncRNAs

VARAdb: a variation annotation database for human


Chen J, Zhang J, Gao Y, Li Y, Feng C, Song C, Ning Z, Zhou X, Zhao J, Feng M, Zhang Y, Wei L, Pan Q, Jiang Y, Qian F, Han J, Yang Y, Wang Q, Li C. LncSEA: a platform for long non-coding RNA related sets and enrichment analysis. Nucleic Acids Res. 2020 Oct 12:gkaa806. doi: 10.1093/nar/gkaa806. Epub ahead of print. PMID: 33045741.