| T(co)F: | Esr1 |
| Species: | Mus musculus |
| Knock-Method: | knockout |
| T(co)F Class: | Nuclear receptors with C4 zinc fingers |
| T(co)F Superclass: | Zinc-coordinating DNA-binding domains |
| Biosample Name: | Liver |
| Tissue Type: | Liver |
| Biosample Type: | Tissue |
| # of Control: | 6 | # of Treat: | 9 |
| Data Source: | GEO |
| Profile ID: | GSE174535 |
| Platform: | GPL24247 |
| Pubmed ID: | 34215813 |
#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines
| Target Gene | T(co)F | Mean
Expr. of
Control
|
Mean
Expr. of
Treat
|
Fold Change | Log2FC | Rank | P-value | Corrected _P |
Promoter _T(co)F |
SE_T(co)F | TE_T(co)F |
|---|
| T(co)F | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Esr1 | MTA3_PATHWAY | BIOCARTA | 19 |
| Esr1 | HER2_PATHWAY | BIOCARTA | 23 |
| Esr1 | EFP_PATHWAY | BIOCARTA | 13 |
| Esr1 | PELP1_PATHWAY | BIOCARTA | 5 |
| Esr1 | SIGNALING_BY_ERBB4 | REACTOME | 34 |
| Esr1 | NUCLEAR_SIGNALING_BY_ERBB4 | REACTOME | 11 |
| Esr1 | NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | REACTOME | 107 |
| Esr1 | GENERIC_TRANSCRIPTION_PATHWAY | REACTOME | 842 |
| Esr1 | SUMOYLATION | REACTOME | 165 |
| Esr1 | NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | REACTOME | 48 |
| Esr1 | METABOLISM_OF_PROTEINS | REACTOME | 1657 |
| Esr1 | SUMOYLATION_OF_INTRACELLULAR_RECEPTORS | REACTOME | 27 |
| Esr1 | DEUBIQUITINATION | REACTOME | 254 |
| Esr1 | OVARIAN_TUMOR_DOMAIN_PROTEASES | REACTOME | 33 |
| Esr1 | POST_TRANSLATIONAL_PROTEIN_MODIFICATION | REACTOME | 1310 |
| Esr1 | GENE_EXPRESSION_TRANSCRIPTION | REACTOME | 1061 |
| Esr1 | TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMIL | REACTOME | 22 |
| Esr1 | TRANSCRIPTIONAL_REGULATION_BY_RUNX1 | REACTOME | 198 |
| Esr1 | ESR_MEDIATED_SIGNALING | REACTOME | 160 |
| Esr1 | INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS | REACTOME | 260 |
| Esr1 | SIGNALING_BY_NUCLEAR_RECEPTORS | REACTOME | 210 |
| Esr1 | SIGNALING_BY_RECEPTOR_TYROSINE_KINASES | REACTOME | 401 |
| Esr1 | EXTRA_NUCLEAR_ESTROGEN_SIGNALING | REACTOME | 68 |
| Esr1 | ESTROGEN_DEPENDENT_GENE_EXPRESSION | REACTOME | 91 |
| Esr1 | NUCLEAR_RECEPTORS | WP | 38 |
| Esr1 | ESTROGEN_SIGNALING | WP | 75 |