T(co)F Overview
T(co)F: Gsk3b
Species: Mus musculus
Knock-Method: CRISPR
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TcoF
Biosample Name: mPFC D2 neurons
Tissue Type: Neuron
Biosample Type: Tissue
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE139564
Platform: GPL19057
Pubmed ID: 32584144

Gsk3b- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Gsk3b
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Gsk3b
Upstream Pathway Annotation of Gsk3b
T(co)F Pathway Name Source Gene Number
Gsk3b G1_PATHWAY BIOCARTA 26
Gsk3b P35ALZHEIMERS_PATHWAY BIOCARTA 6
Gsk3b GSK3_PATHWAY BIOCARTA 21
Gsk3b PITX2_PATHWAY BIOCARTA 15
Gsk3b NFAT_PATHWAY BIOCARTA 47
Gsk3b PTDINS_PATHWAY BIOCARTA 15
Gsk3b PS1_PATHWAY BIOCARTA 14
Gsk3b EIF2_PATHWAY BIOCARTA 9
Gsk3b IGF1MTOR_PATHWAY BIOCARTA 18
Gsk3b SHH_PATHWAY BIOCARTA 15
Gsk3b WNT_PATHWAY BIOCARTA 23
Gsk3b HES_PATHWAY BIOCARTA 12
Gsk3b DEVELOPMENTAL_BIOLOGY REACTOME 484
Gsk3b DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COM REACTOME 80
Gsk3b SIGNALING_BY_WNT REACTOME 235
Gsk3b BETA_CATENIN_PHOSPHORYLATION_CASCADE REACTOME 17
Gsk3b TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT REACTOME 154
Gsk3b EPIGENETIC_REGULATION_OF_GENE_EXPRESSION REACTOME 112
Gsk3b REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE REACTOME 63
Gsk3b CELLULAR_RESPONSE_TO_HEAT_STRESS REACTOME 82
Gsk3b SEMAPHORIN_INTERACTIONS REACTOME 51
Gsk3b CRMPS_IN_SEMA3A_SIGNALING REACTOME 15
Gsk3b DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUIT REACTOME 30
Gsk3b POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION REACTOME 30
Gsk3b SIGNALING_BY_HEDGEHOG REACTOME 140
Gsk3b GLI3_IS_PROCESSED_TO_GLI3R_BY_THE_PROTEASOME REACTOME 58
Gsk3b HEDGEHOG_OFF_STATE REACTOME 108
Gsk3b GENE_EXPRESSION_TRANSCRIPTION REACTOME 1061
Gsk3b CELLULAR_RESPONSES_TO_STIMULI REACTOME 454
Gsk3b NERVOUS_SYSTEM_DEVELOPMENT REACTOME 262
Gsk3b CELLULAR_RESPONSE_TO_CHEMICAL_STRESS REACTOME 160
Gsk3b KEAP1_NFE2L2_PATHWAY REACTOME 76
Gsk3b NUCLEAR_EVENTS_MEDIATED_BY_NFE2L2 REACTOME 54
Gsk3b IL6_SIGNALING_PATHWAY WP 99
Gsk3b WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY WP 97
Gsk3b ESC_PLURIPOTENCY_PATHWAYS WP 116
Gsk3b IL7_SIGNALING_PATHWAY WP 43
Gsk3b WNT_SIGNALING_IN_KIDNEY_DISEASE WP 43
Gsk3b IL3_SIGNALING_PATHWAY WP 99
Gsk3b WNT_SIGNALING_PATHWAY_WP403 WP 60
Gsk3b MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY WP 100
Gsk3b FOCAL_ADHESION WP 185
Gsk3b FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY WP 317
Gsk3b DELTANOTCH_SIGNALING_PATHWAY WP 82
Gsk3b NEURAL_CREST_DIFFERENTIATION WP 99
Gsk3b IL5_SIGNALING_PATHWAY WP 68
Gsk3b CHEMOKINE_SIGNALING_PATHWAY WP 174
Gsk3b ERBB_SIGNALING_PATHWAY WP 46
Gsk3b INSULIN_SIGNALING WP 158
Gsk3b ALZHEIMERS_DISEASE WP 74
Gsk3b WNT_SIGNALING_PATHWAY_WP539 WP 108
Gsk3b MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY WP 290
Gsk3b GLYCOGEN_METABOLISM WP 34
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Gsk3b
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)