T(co)F Overview
T(co)F: Brca1
Species: Mus musculus
Knock-Method: knockout
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TF
Biosample Name: mouse P7 cortex
Tissue Type: Brain
Biosample Type: Tissue
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE6310
Platform: GPL8321
Pubmed ID: 21901007

Brca1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Brca1
Target Gene T(co)F Mean
Expr. of
Control
Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P
Promoter
_T(co)F
SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Brca1

Upstream Pathway Annotation of Brca1
T(co)F Pathway Name Source Gene Number
Brca1 ATM_PATHWAY BIOCARTA 19
Brca1 G2_PATHWAY BIOCARTA 22
Brca1 ATRBRCA_PATHWAY BIOCARTA 19
Brca1 CELL_CYCLE REACTOME 601
Brca1 GENERIC_TRANSCRIPTION_PATHWAY REACTOME 842
Brca1 SUMOYLATION REACTOME 165
Brca1 SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROT REACTOME 74
Brca1 TRANSCRIPTIONAL_REGULATION_BY_TP53 REACTOME 301
Brca1 METABOLISM_OF_PROTEINS REACTOME 1657
Brca1 REGULATION_OF_TP53_ACTIVITY REACTOME 155
Brca1 HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA REACTOME 35
Brca1 HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR REACTOME 56
Brca1 DEUBIQUITINATION REACTOME 254
Brca1 METALLOPROTEASE_DUBS REACTOME 39
Brca1 DNA_DOUBLE_STRAND_BREAK_REPAIR REACTOME 160
Brca1 RESOLUTION_OF_D_LOOP_STRUCTURES REACTOME 32
Brca1 HOMOLOGY_DIRECTED_REPAIR REACTOME 131
Brca1 NONHOMOLOGOUS_END_JOINING_NHEJ REACTOME 66
Brca1 HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE REACTOME 26
Brca1 DNA_DOUBLE_STRAND_BREAK_RESPONSE REACTOME 76
Brca1 PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS REACTOME 88
Brca1 POST_TRANSLATIONAL_PROTEIN_MODIFICATION REACTOME 1310
Brca1 REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATIO REACTOME 91
Brca1 G2_M_DNA_DAMAGE_CHECKPOINT REACTOME 90
Brca1 G2_M_CHECKPOINTS REACTOME 163
Brca1 CELL_CYCLE_CHECKPOINTS REACTOME 286
Brca1 DNA_REPAIR REACTOME 299
Brca1 GENE_EXPRESSION_TRANSCRIPTION REACTOME 1061
Brca1 ESTROGEN_SIGNALING WP 75
Brca1 MRNA_PROCESSING WP 449
Brca1 MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY WP 290
Target Gene Expression Analysis
Expression Atlas of Brca1