T(co)F Overview
T(co)F: Tcf7
Species: Mus musculus
Knock-Method: shRNA
T(co)F Class: High-mobility group (HMG) domain factors
T(co)F Superclass: Other all-alpha-helical DNA-binding domains
Biosample Name: EML
Tissue Type: Hematopoietic
Biosample Type: Cell line
# of Control: 1
# of Treat: 2
Data Source: GEO
Profile ID: GSE30068
Platform: GPL6887
Pubmed ID: 22412390

Tcf7- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Tcf7
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Tcf7
Upstream Pathway Annotation of Tcf7
T(co)F Pathway Name Source Gene Number
Tcf7 DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COM REACTOME 80
Tcf7 SIGNALING_BY_WNT REACTOME 235
Tcf7 TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT REACTOME 154
Tcf7 FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_ REACTOME 23
Tcf7 GENERIC_TRANSCRIPTION_PATHWAY REACTOME 842
Tcf7 DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_C REACTOME 32
Tcf7 BETA_CATENIN_INDEPENDENT_WNT_SIGNALING REACTOME 127
Tcf7 CA2_PATHWAY REACTOME 47
Tcf7 REPRESSION_OF_WNT_TARGET_GENES REACTOME 10
Tcf7 GENE_EXPRESSION_TRANSCRIPTION REACTOME 1061
Tcf7 TRANSCRIPTIONAL_REGULATION_BY_VENTX REACTOME 6
Tcf7 TRANSCRIPTIONAL_REGULATION_BY_RUNX3 REACTOME 78
Tcf7 RUNX3_REGULATES_WNT_SIGNALING REACTOME 6
Tcf7 MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY WP 290
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Tcf7
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)