T(co)F Overview
T(co)F: Klf4
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: C2H2 zinc finger factors
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: Primary neonatal keratinocytes
Tissue Type: Skin
Biosample Type: Primary cell
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE32685
Platform: GPL570
Pubmed ID: 22364861

Klf4- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Klf4
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Klf4
Upstream Pathway Annotation of Klf4
T(co)F Pathway Name Source Gene Number
Klf4 Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 WikiPathways 9
Klf4 Synthesis, secretion, and deacylation of Ghrelin Reactome 17
Klf4 Transcriptional regulation of pluripotent stem cells Reactome 28
Klf4 Hs_White_fat_cell_differentiation_WP3946_90940 WikiPathways 30
Klf4 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 WikiPathways 47
Klf4 Transcriptional regulation of white adipocyte differentiation Reactome 79
Klf4 Regulation of nuclear beta catenin signaling and target gene transcription PID 80
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Klf4
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines