T(co)F Overview
T(co)F: ETS1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Tryptophan cluster factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: WI38
Tissue Type: Fibroblasts
Biosample Type: Cell line
# of Control: 14
# of Treat: 8
Data Source: GEO
Profile ID: GSE122918
Platform: GPL17586
Pubmed ID: 32514071

ETS1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ETS1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ETS1
Upstream Pathway Annotation of ETS1
T(co)F Pathway Name Source Gene Number
ETS1 MAPK signaling pathway - fly KEGG 16
ETS1 ERK cascade ( FGF8 signaling (Mouse) ) INOH 17
ETS1 ERK cascade ( FGF8 signaling (Xenopus) ) INOH 17
ETS1 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH 18
ETS1 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH 20
ETS1 Dorso-ventral axis formation KEGG 25
ETS1 Oncogene Induced Senescence Reactome 30
ETS1 HIF-2-alpha transcription factor network PID 34
ETS1 Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways 40
ETS1 Angiopoietin receptor Tie2-mediated signaling PID 50
ETS1 Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 WikiPathways 51
ETS1 VEGF signaling pathway PANTHER 54
ETS1 Signaling events mediated by focal adhesion kinase PID 63
ETS1 IL4-mediated signaling events PID 66
ETS1 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways 67
ETS1 HIF-1-alpha transcription factor network PID 67
ETS1 Ras Pathway PANTHER 69
ETS1 BCR signaling pathway PID 70
ETS1 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 WikiPathways 71
ETS1 AP-1 transcription factor network PID 71
ETS1 IL4 NetPath 75
ETS1 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PID 80
ETS1 IL2 NetPath 81
ETS1 C-MYB transcription factor network PID 87
ETS1 PDGF signaling pathway PANTHER 113
ETS1 Angiogenesis PANTHER 141
ETS1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways 153
ETS1 TGF_beta_Receptor NetPath 220
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of ETS1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines