T(co)F Overview
T(co)F: ESRRA
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Nuclear receptors with C4 zinc fingers
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: MCF7
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 3
# of Treat: 1
Data Source: GEO
Profile ID: GSE31912
Platform: GPL570
Pubmed ID: 22536322

ESRRA- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ESRRA
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ESRRA
Upstream Pathway Annotation of ESRRA
T(co)F Pathway Name Source Gene Number
ESRRA Hs_Mitochondrial_Gene_Expression_WP391_71373 WikiPathways 11
ESRRA Hs_Energy_Metabolism_WP1541_91584 WikiPathways 13
ESRRA Transcriptional activation of mitochondrial biogenesis Reactome 43
ESRRA Nuclear Receptor transcription pathway Reactome 51
ESRRA PPARA activates gene expression Reactome 113
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of ESRRA
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines