T(co)F Overview
T(co)F: AR
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Nuclear receptors with C4 zinc fingers
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: LNCaP
Tissue Type: Prostate
Biosample Type: Cell line
# of Control: 6
# of Treat: 6
Data Source: GEO
Profile ID: GSE49285
Platform: GPL10558
Pubmed ID: 24847116

AR- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of AR
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of AR
Upstream Pathway Annotation of AR
T(co)F Pathway Name Source Gene Number
AR Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways 27
AR Hs_DNA_Damage_Response_WP707_82937 WikiPathways 28
AR Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 WikiPathways 28
AR Nongenotropic Androgen signaling PID 31
AR Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways 33
AR FOXA1 transcription factor network PID 45
AR Notch-mediated HES/HEY network PID 48
AR Nuclear Receptor transcription pathway Reactome 51
AR Regulation of Androgen receptor activity PID 54
AR Coregulation of Androgen receptor activity PID 61
AR Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Reactome 65
AR Alpha6Beta4Integrin NetPath 74
AR Regulation of nuclear beta catenin signaling and target gene transcription PID 80
AR Regulation of nuclear SMAD2/3 signaling PID 82
AR Prostate cancer KEGG 85
AR IL6 NetPath 85
AR Oocyte meiosis KEGG 110
AR Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
AR AndrogenReceptor NetPath 167
AR TGF_beta_Receptor NetPath 220
AR Pathways in cancer KEGG 321
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of AR
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines