T(co)F Overview
T(co)F: TLE2
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: Others
T(co)F Superclass: Other Cofactors
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR399QAP
Platform: -
Pubmed ID: 22955616

TLE2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of TLE2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of TLE2
Upstream Pathway Annotation of TLE2
T(co)F Pathway Name Source Gene Number
TLE2 Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH 8
TLE2 Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) INOH 8
TLE2 Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH 8
TLE2 Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) INOH 8
TLE2 Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH 8
TLE2 Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) INOH 8
TLE2 Repression of WNT target genes Reactome 14
TLE2 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) INOH 21
TLE2 Deactivation of the beta-catenin transactivating complex Reactome 42
TLE2 NOTCH1 Intracellular Domain Regulates Transcription Reactome 47
TLE2 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH 47
TLE2 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) INOH 47
TLE2 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH 47
TLE2 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) INOH 47
TLE2 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH 47
TLE2 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) INOH 47
TLE2 Regulation of nuclear beta catenin signaling and target gene transcription PID 80
TLE2 Formation of the beta-catenin:TCF transactivating complex Reactome 88
TLE2 Wnt signaling pathway PANTHER 250
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of TLE2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines