T(co)F Overview
T(co)F: RUNX2
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Runt domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: SKOV3
Tissue Type: Ovary
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE46477
Platform: GPL4133
Pubmed ID: 24124450

RUNX2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of RUNX2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of RUNX2
Upstream Pathway Annotation of RUNX2
T(co)F Pathway Name Source Gene Number
RUNX2 Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082 WikiPathways 6
RUNX2 Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 WikiPathways 8
RUNX2 Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 WikiPathways 9
RUNX2 YAP1- and WWTR1 (TAZ)-stimulated gene expression Reactome 29
RUNX2 Hs_Endochondral_Ossification_WP474_87977 WikiPathways 43
RUNX2 Notch-mediated HES/HEY network PID 48
RUNX2 FGF signaling pathway PID 55
RUNX2 Hs_MAPK_Signaling_Pathway_WP382_79951 WikiPathways 58
RUNX2 Regulation of retinoblastoma protein PID 67
RUNX2 Regulation of nuclear SMAD2/3 signaling PID 82
RUNX2 Leptin NetPath 98
RUNX2 AndrogenReceptor NetPath 167
RUNX2 TGF_beta_Receptor NetPath 220
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of RUNX2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines