T(co)F Overview
T(co)F: RUNX1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Runt domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: MV4-11
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 1
# of Treat: 3
Data Source: GEO
Profile ID: GSE98748
Platform: GPL17692
Pubmed ID: -

RUNX1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of RUNX1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of RUNX1
Upstream Pathway Annotation of RUNX1
T(co)F Pathway Name Source Gene Number
RUNX1 Organic cation transport Reactome 9
RUNX1 Validated transcriptional targets of deltaNp63 isoforms PID 47
RUNX1 Acute myeloid leukemia KEGG 53
RUNX1 Chronic myeloid leukemia KEGG 69
RUNX1 Regulation of nuclear SMAD2/3 signaling PID 82
RUNX1 RANKL NetPath 84
RUNX1 AndrogenReceptor NetPath 167
RUNX1 TGF_beta_Receptor NetPath 220
RUNX1 Pathways in cancer KEGG 321
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of RUNX1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines