T(co)F Overview
T(co)F: FOXO3
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Fork head / winged helix factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: PANC1
Tissue Type: Pancreas
Biosample Type: Cell line
# of Control: 1
# of Treat: 1
Data Source: GEO
Profile ID: GSE66404
Platform: GPL17077
Pubmed ID: -

FOXO3- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of FOXO3
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of FOXO3
Upstream Pathway Annotation of FOXO3
T(co)F Pathway Name Source Gene Number
FOXO3 Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) INOH 7
FOXO3 Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) INOH 7
FOXO3 Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 WikiPathways 8
FOXO3 AKT phosphorylates targets in the nucleus Reactome 9
FOXO3 Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384 WikiPathways 11
FOXO3 Hs_Energy_Metabolism_WP1541_91584 WikiPathways 13
FOXO3 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways 13
FOXO3 Signaling by NODAL Reactome 19
FOXO3 Insulin/IGF pathway-protein kinase B signaling cascade PANTHER 22
FOXO3 Constitutive Signaling by AKT1 E17K in Cancer Reactome 25
FOXO3 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 WikiPathways 27
FOXO3 IL-7 NetPath 28
FOXO3 Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways 33
FOXO3 Class I PI3K signaling events mediated by Akt PID 35
FOXO3 Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 WikiPathways 36
FOXO3 Trk receptor signaling mediated by PI3K and PLC-gamma PID 36
FOXO3 PI3 kinase pathway PANTHER 38
FOXO3 IL2 signaling events mediated by PI3K PID 38
FOXO3 Signaling events mediated by HDAC Class III PID 41
FOXO3 Hs_Endochondral_Ossification_WP474_87977 WikiPathways 43
FOXO3 FSH NetPath 44
FOXO3 Class I PI3K signaling events PID 46
FOXO3 Insulin Pathway PID 47
FOXO3 FoxO family signaling PID 50
FOXO3 Endometrial cancer KEGG 52
FOXO3 Signaling events mediated by Stem cell factor receptor (c-Kit) PID 53
FOXO3 Non-small cell lung cancer KEGG 54
FOXO3 IL5 NetPath 59
FOXO3 Validated targets of C-MYC transcriptional repression PID 63
FOXO3 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 WikiPathways 80
FOXO3 p73 transcription factor network PID 80
FOXO3 IL2 NetPath 81
FOXO3 Regulation of nuclear SMAD2/3 signaling PID 82
FOXO3 IL3 NetPath 84
FOXO3 IL6 NetPath 85
FOXO3 Interleukin signaling pathway PANTHER 86
FOXO3 MAPK6/MAPK4 signaling Reactome 90
FOXO3 KitReceptor NetPath 104
FOXO3 Prolactin NetPath 105
FOXO3 Neurotrophin signaling pathway KEGG 126
FOXO3 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways 153
FOXO3 BCR NetPath 161
FOXO3 Chemokine signaling pathway KEGG 187
FOXO3 TGF_beta_Receptor NetPath 220
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of FOXO3
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines