T(co)F Overview
T(co)F: HIF1A
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Basic helix-loop-helix factors (bHLH)
T(co)F Superclass: Basic domains
Biosample Name: Primary human macrophages
Tissue Type: Blood
Biosample Type: Cell line
# of Control: 12
# of Treat: 12
Data Source: GEO
Profile ID: GSE56989
Platform: GPL6244
Pubmed ID: 25450522

HIF1A- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of HIF1A
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of HIF1A
Upstream Pathway Annotation of HIF1A
T(co)F Pathway Name Source Gene Number
HIF1A PTK6 Expression Reactome 5
HIF1A PTK6 promotes HIF1A stabilization Reactome 6
HIF1A Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 WikiPathways 8
HIF1A Regulation of gene expression by Hypoxia-inducible Factor Reactome 10
HIF1A Hs_Notch_Signaling_Pathway_WP61_78592 WikiPathways 16
HIF1A Hypoxia response via HIF activation PANTHER 16
HIF1A Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Reactome 18
HIF1A Hypoxic and oxygen homeostasis regulation of HIF-1-alpha PID 19
HIF1A Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways 27
HIF1A VEGFR1 specific signals PID 29
HIF1A Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 WikiPathways 36
HIF1A BMAL1:CLOCK,NPAS2 activates circadian gene expression Reactome 42
HIF1A NOTCH1 Intracellular Domain Regulates Transcription Reactome 47
HIF1A Notch-mediated HES/HEY network PID 48
HIF1A Circadian Clock Reactome 49
HIF1A mTOR signaling pathway KEGG 50
HIF1A VEGF signaling pathway PANTHER 54
HIF1A Renal cell carcinoma KEGG 65
HIF1A HIF-1-alpha transcription factor network PID 67
HIF1A AP-1 transcription factor network PID 71
HIF1A Parkinson disease PANTHER 85
HIF1A Angiogenesis PANTHER 141
HIF1A Pathways in cancer KEGG 321
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of HIF1A
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines