T(co)F Overview
T(co)F: XBP1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Basic leucine zipper factors (bZIP)
T(co)F Superclass: Basic domains
Biosample Name: MDA-MB-231
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE49953
Platform: GPL570
Pubmed ID: 24670641

XBP1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of XBP1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of XBP1
Upstream Pathway Annotation of XBP1
T(co)F Pathway Name Source Gene Number
XBP1 Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 WikiPathways 6
XBP1 ATF6-alpha activates chaperone genes Reactome 10
XBP1 FOXA1 transcription factor network PID 45
XBP1 XBP1(S) activates chaperone genes Reactome 53
XBP1 Validated nuclear estrogen receptor alpha network PID 65
XBP1 Protein processing in endoplasmic reticulum KEGG 166
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of XBP1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines