T(co)F Overview
T(co)F: HSF1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Heat shock factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: A375
Tissue Type: Skin
Biosample Type: Cell line
# of Control: 12
# of Treat: 4
Data Source: GEO
Profile ID: GSE44867
Platform: GPL570
Pubmed ID: 23615731

HSF1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of HSF1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of HSF1
Upstream Pathway Annotation of HSF1
T(co)F Pathway Name Source Gene Number
HSF1 Attenuation phase Reactome 28
HSF1 HSF1 activation Reactome 31
HSF1 HSF1-dependent transactivation Reactome 34
HSF1 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 WikiPathways 50
HSF1 p73 transcription factor network PID 80
HSF1 Regulation of HSF1-mediated heat shock response Reactome 82
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of HSF1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines