T(co)F Overview
T(co)F: IRF6
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Tryptophan cluster factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: Primary CD34+ hematopoietic stem/progenitor cells (HSPCs)
Tissue Type: Fetal_liver
Biosample Type: Primary cell
# of Control: 4
# of Treat: 3
Data Source: GEO
Profile ID: GSE36988
Platform: GPL15394
Pubmed ID: 23041383

IRF6- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of IRF6
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of IRF6
Upstream Pathway Annotation of IRF6
T(co)F Pathway Name Source Gene Number
IRF6 Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 WikiPathways 5
IRF6 Interferon alpha/beta signaling Reactome 67
IRF6 Interferon gamma signaling Reactome 88
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of IRF6
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines