T(co)F Overview
T(co)F: IRF2
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Tryptophan cluster factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: Primary CD34+ hematopoietic stem/progenitor cells (HSPCs)
Tissue Type: Fetal_liver
Biosample Type: Primary cell
# of Control: 4
# of Treat: 3
Data Source: GEO
Profile ID: GSE36988
Platform: GPL15394
Pubmed ID: 23041383

IRF2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of IRF2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of IRF2
Upstream Pathway Annotation of IRF2
T(co)F Pathway Name Source Gene Number
IRF2 Hs_Inflammatory_Response_Pathway_WP453_80206 WikiPathways 6
IRF2 Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 WikiPathways 10
IRF2 TRAF6 mediated IRF7 activation Reactome 33
IRF2 Interferon alpha/beta signaling Reactome 67
IRF2 Interferon gamma signaling Reactome 88
IRF2 Factors involved in megakaryocyte development and platelet production Reactome 111
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of IRF2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines