T(co)F Overview
T(co)F: FOS
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Basic leucine zipper factors (bZIP)
T(co)F Superclass: Basic domains
Biosample Name: MCF7
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 6
# of Treat: 8
Data Source: GEO
Profile ID: GSE36586
Platform: GPL14550
Pubmed ID: 22791811

FOS- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of FOS
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of FOS
Upstream Pathway Annotation of FOS
T(co)F Pathway Name Source Gene Number
FOS Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) INOH 5
FOS Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) INOH 5
FOS Hs_Serotonin_and_anxiety-related_events_WP3944_90836 WikiPathways 9
FOS Activation of the AP-1 family of transcription factors Reactome 10
FOS JNK cascade ( CD4 T cell receptor signaling ) INOH 10
FOS JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) INOH 12
FOS Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways 13
FOS Ras signaling in the CD4+ TCR pathway PID 14
FOS PDGFR-alpha signaling pathway PID 22
FOS S1P2 pathway PID 26
FOS Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade PANTHER 29
FOS Calcium signaling in the CD4+ TCR pathway PID 29
FOS Nongenotropic Androgen signaling PID 31
FOS Osteopontin-mediated events PID 32
FOS IL12 signaling mediated by STAT4 PID 33
FOS Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 WikiPathways 34
FOS Trk receptor signaling mediated by the MAPK pathway PID 34
FOS Hs_IL-5_Signaling_Pathway_WP127_78498 WikiPathways 35
FOS Hs_IL-3_Signaling_Pathway_WP286_78583 WikiPathways 35
FOS GMCSF-mediated signaling events PID 38
FOS FCERI mediated MAPK activation Reactome 40
FOS Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways 41
FOS Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways 41
FOS ErbB2/ErbB3 signaling events PID 41
FOS FOXM1 transcription factor network PID 43
FOS Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways 44
FOS FOXA1 transcription factor network PID 45
FOS Presenilin action in Notch and Wnt signaling PID 46
FOS RhoA signaling pathway PID 46
FOS IL6-mediated signaling events PID 48
FOS Calcineurin-regulated NFAT-dependent transcription in lymphocytes PID 50
FOS B cell activation PANTHER 52
FOS IL2-mediated signaling events PID 54
FOS FGF signaling pathway PID 55
FOS ATF-2 transcription factor network PID 59
FOS T cell activation PANTHER 60
FOS TP53 Regulates Transcription of DNA Repair Genes Reactome 61
FOS IL12-mediated signaling events PID 62
FOS Colorectal cancer KEGG 63
FOS Endothelins PID 64
FOS Fc-epsilon receptor I signaling in mast cells PID 64
FOS LPA receptor mediated events PID 65
FOS HIF-1-alpha transcription factor network PID 67
FOS Downstream signaling in nave CD8+ T cells PID 69
FOS B cell receptor signaling pathway KEGG 70
FOS Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293 WikiPathways 70
FOS BCR signaling pathway PID 70
FOS Regulation of Telomerase PID 70
FOS Leishmaniasis KEGG 71
FOS AP-1 transcription factor network PID 71
FOS Alpha6Beta4Integrin NetPath 74
FOS Regulation of nuclear SMAD2/3 signaling PID 82
FOS IL6 NetPath 85
FOS Glucocorticoid receptor regulatory network PID 85
FOS Interleukin signaling pathway PANTHER 86
FOS Toll-like receptor signaling pathway KEGG 100
FOS Chagas disease KEGG 103
FOS Apoptosis signaling pathway PANTHER 104
FOS T cell receptor signaling pathway KEGG 105
FOS Prolactin NetPath 105
FOS ErbB1 downstream signaling PID 105
FOS Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways 107
FOS Senescence-Associated Secretory Phenotype (SASP) Reactome 108
FOS Huntington disease PANTHER 113
FOS PDGF signaling pathway PANTHER 113
FOS Oxidative Stress Induced Senescence Reactome 120
FOS PDGFR-beta signaling pathway PID 125
FOS Angiogenesis PANTHER 141
FOS BCR NetPath 161
FOS TGF_beta_Receptor NetPath 220
FOS TCR NetPath 261
FOS MAPK signaling pathway KEGG 264
FOS Pathways in cancer KEGG 321
FOS EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of FOS
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines