T(co)F Overview
T(co)F: RELA
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Rel homology region (RHR) factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: A375
Tissue Type: Skin
Biosample Type: Cell line
# of Control: 3
# of Treat: 1
Data Source: GEO
Profile ID: GSE31534
Platform: GPL570
Pubmed ID: 22536322

RELA- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of RELA
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of RELA
Upstream Pathway Annotation of RELA
T(co)F Pathway Name Source Gene Number
RELA CLEC7A/inflammasome pathway Reactome 6
RELA IkBA variant leads to EDA-ID Reactome 7
RELA Interleukin-1 processing Reactome 7
RELA IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Reactome 8
RELA IKK-NF-kappaB cascade ( B cell receptor signaling ) INOH 8
RELA IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) INOH 8
RELA IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) INOH 8
RELA Regulated proteolysis of p75NTR Reactome 10
RELA IKK-NFkB cascade ( TNFR1 signaling pathway ) INOH 11
RELA NF-kB signaling ( Toll-like receptor signaling pathway (trough NF-kappaB) ) INOH 12
RELA DEx/H-box helicases activate type I IFN and inflammatory cytokines production Reactome 13
RELA NF-kB is activated and signals survival Reactome 13
RELA Atypical NF-kappaB pathway PID 14
RELA Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways 17
RELA Hs_IL17_signaling_pathway_WP2112_89838 WikiPathways 20
RELA CD209 (DC-SIGN) signaling Reactome 21
RELA RIP-mediated NFkB activation via ZBP1 Reactome 21
RELA TRAF6 mediated NF-kB activation Reactome 24
RELA TSLP NetPath 24
RELA Canonical NF-kappaB pathway PID 24
RELA TAK1 activates NFkB by phosphorylation and activation of IKKs complex Reactome 26
RELA Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 WikiPathways 26
RELA Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910 WikiPathways 27
RELA Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways 27
RELA Hs_p38_MAPK_Signaling_Pathway_WP400_72084 WikiPathways 28
RELA T cell receptor signaling (PLC gamma, PKC, Ras and IKK-NF-kappaB cascade) ( CD4 T cell receptor signaling (NF-kB cascade) ) INOH 30
RELA Osteopontin-mediated events PID 32
RELA HIV-1 Nef: Negative effector of Fas and TNF-alpha PID 33
RELA T cell receptor signaling pathway ( CD4 T cell receptor signaling ) INOH 33
RELA Hs_IL-1_signaling_pathway_WP195_89932 WikiPathways 34
RELA IL1-mediated signaling events PID 34
RELA TWEAK NetPath 35
RELA CD40/CD40L signaling PID 36
RELA Hs_Nucleotide-binding_Oligomerization_Domain_(NOD)_pathway_WP1433_86035 WikiPathways 37
RELA IL23-mediated signaling events PID 37
RELA IL2 signaling events mediated by PI3K PID 38
RELA Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways 41
RELA FSH NetPath 44
RELA Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways 44
RELA TNF receptor signaling pathway PID 46
RELA Ceramide signaling pathway PID 49
RELA Angiopoietin receptor Tie2-mediated signaling PID 50
RELA Hs_Prolactin_Signaling_Pathway_WP2037_90015 WikiPathways 52
RELA Acute myeloid leukemia KEGG 53
RELA Cytosolic DNA-sensing pathway KEGG 56
RELA NOD-like receptor signaling pathway KEGG 60
RELA Shigellosis KEGG 60
RELA Dectin-1 mediated noncanonical NF-kB signaling Reactome 61
RELA IL12-mediated signaling events PID 62
RELA Fc-epsilon receptor I signaling in mast cells PID 64
RELA Adipocytokine signaling pathway KEGG 65
RELA LPA receptor mediated events PID 65
RELA Activation of NF-kappaB in B cells Reactome 66
RELA Epithelial cell signaling in Helicobacter pylori infection KEGG 67
RELA Chronic myeloid leukemia KEGG 69
RELA IL1 NetPath 69
RELA B cell receptor signaling pathway KEGG 70
RELA Pancreatic cancer KEGG 70
RELA BCR signaling pathway PID 70
RELA RIG-I-like receptor signaling pathway KEGG 71
RELA Leishmaniasis KEGG 71
RELA IL4 NetPath 75
RELA Notch NetPath 76
RELA CLEC7A (Dectin-1) signaling Reactome 78
RELA Transcriptional regulation of white adipocyte differentiation Reactome 79
RELA Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 WikiPathways 80
RELA p73 transcription factor network PID 80
RELA IL2 NetPath 81
RELA TSH NetPath 82
RELA Small cell lung cancer KEGG 83
RELA RANKL NetPath 84
RELA Prostate cancer KEGG 85
RELA Glucocorticoid receptor regulatory network PID 85
RELA Apoptosis KEGG 88
RELA FCERI mediated NF-kB activation Reactome 88
RELA Signaling events mediated by HDAC Class I PID 89
RELA Leptin NetPath 98
RELA Toll-like receptor signaling pathway KEGG 100
RELA Downstream TCR signaling Reactome 101
RELA Chagas disease KEGG 103
RELA Amoebiasis KEGG 103
RELA KitReceptor NetPath 104
RELA Apoptosis signaling pathway PANTHER 104
RELA T cell receptor signaling pathway KEGG 105
RELA Prolactin NetPath 105
RELA Senescence-Associated Secretory Phenotype (SASP) Reactome 108
RELA Neurotrophin signaling pathway KEGG 126
RELA Toxoplasmosis KEGG 131
RELA Hepatitis C KEGG 134
RELA Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways 153
RELA BCR NetPath 161
RELA Chemokine signaling pathway KEGG 187
RELA Inflammation mediated by chemokine and cytokine signaling pathway PANTHER 189
RELA TCR NetPath 261
RELA MAPK signaling pathway KEGG 264
RELA TNFalpha NetPath 274
RELA Pathways in cancer KEGG 321
RELA EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of RELA
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines