T(co)F Overview
T(co)F: POU5F1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Homeo domain factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: H1-hESC
Tissue Type: Embryo
Biosample Type: Stem cell
# of Control: 6
# of Treat: 6
Data Source: GEO
Profile ID: GSE21135
Platform: GPL6947
Pubmed ID: 20526341

POU5F1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of POU5F1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of POU5F1
Upstream Pathway Annotation of POU5F1
T(co)F Pathway Name Source Gene Number
POU5F1 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome 10
POU5F1 Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 WikiPathways 12
POU5F1 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Reactome 13
POU5F1 Transcriptional regulation of pluripotent stem cells Reactome 28
POU5F1 HIF-2-alpha transcription factor network PID 34
POU5F1 Hs_Endoderm_Differentiation_WP2853_88152 WikiPathways 62
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of POU5F1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines