T(co)F Overview
T(co)F: CREB1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Basic leucine zipper factors (bZIP)
T(co)F Superclass: Basic domains
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 10
# of Treat: 10
Data Source: GEO
Profile ID: GSE12056
Platform: GPL570
Pubmed ID: 18801183

CREB1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of CREB1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of CREB1
Upstream Pathway Annotation of CREB1
T(co)F Pathway Name Source Gene Number
CREB1 CaMK IV-mediated phosphorylation of CREB Reactome 5
CREB1 CREB phosphorylation through the activation of CaMKK Reactome 6
CREB1 CREB phosphorylation Reactome 7
CREB1 CREB phosphorylation through the activation of Adenylate Cyclase Reactome 7
CREB1 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin SMPDB 7
CREB1 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin SMPDB 7
CREB1 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin SMPDB 7
CREB1 Intracellular Signalling Through Histamine H2 Receptor and Histamine SMPDB 8
CREB1 AKT phosphorylates targets in the nucleus Reactome 9
CREB1 Gastrin-CREB signalling pathway via PKC and MAPK Reactome 9
CREB1 Heterotrimeric GPCR signaling pathway (through Adenosine G alpha s) ( GPCR Adenosine A2A receptor signaling pathway ) INOH 9
CREB1 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone SMPDB 10
CREB1 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin SMPDB 10
CREB1 NOTCH2 intracellular domain regulates transcription Reactome 12
CREB1 CREB phosphorylation through the activation of Ras Reactome 13
CREB1 LPA4-mediated signaling events PID 16
CREB1 CREB phosphorylation through the activation of CaMKII Reactome 17
CREB1 Enkephalin release PANTHER 17
CREB1 p38 signaling mediated by MAPKAP kinases PID 21
CREB1 NCAM signaling for neurite out-growth Reactome 22
CREB1 Constitutive Signaling by AKT1 E17K in Cancer Reactome 25
CREB1 VEGFR3 signaling in lymphatic endothelium PID 26
CREB1 Nongenotropic Androgen signaling PID 31
CREB1 Trk receptor signaling mediated by the MAPK pathway PID 34
CREB1 Vasopressin-regulated water reabsorption KEGG 35
CREB1 Signaling mediated by p38-alpha and p38-beta PID 35
CREB1 Trk receptor signaling mediated by PI3K and PLC-gamma PID 36
CREB1 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine SMPDB 37
CREB1 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine SMPDB 38
CREB1 Signaling events regulated by Ret tyrosine kinase PID 39
CREB1 BMAL1:CLOCK,NPAS2 activates circadian gene expression Reactome 42
CREB1 Transcriptional activation of mitochondrial biogenesis Reactome 43
CREB1 LKB1 signaling events PID 43
CREB1 FSH NetPath 44
CREB1 FOXA2 and FOXA3 transcription factor networks PID 45
CREB1 Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s) ( GPCR Dopamine D1like receptor signaling pathway ) INOH 45
CREB1 Integrin-linked kinase signaling PID 46
CREB1 Circadian Clock Reactome 49
CREB1 ATF-2 transcription factor network PID 59
CREB1 Validated targets of C-MYC transcriptional repression PID 63
CREB1 HIF-1-alpha transcription factor network PID 67
CREB1 AP-1 transcription factor network PID 71
CREB1 Antigen processing and presentation KEGG 75
CREB1 IL2 NetPath 81
CREB1 TSH NetPath 82
CREB1 Regulation of nuclear SMAD2/3 signaling PID 82
CREB1 IL3 NetPath 84
CREB1 RANKL NetPath 84
CREB1 Prostate cancer KEGG 85
CREB1 Glucocorticoid receptor regulatory network PID 85
CREB1 Leptin NetPath 98
CREB1 Melanogenesis KEGG 100
CREB1 ErbB1 downstream signaling PID 105
CREB1 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway PANTHER 126
CREB1 BCR NetPath 161
CREB1 AndrogenReceptor NetPath 167
CREB1 Huntington's disease KEGG 182
CREB1 TCR NetPath 261
CREB1 TNFalpha NetPath 274
CREB1 EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of CREB1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines